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Pain

Pain is the adverse sensation associated with injury, arthritis, and various forms of nerve injury that impairs well being and day-to-day living. Supplements may either universally reduce pain, or may alleviate the pain associated with a disease state.

Our evidence-based analysis on pain features 29 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect pain.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Minor Very High See all 8 studies
There appears to be a decrease in pain, with one meta-analysis noting that over the long term it account for "a 13 point reduction on a scale of 0-100". Although present, it is not as effective as most painkillers and may be exclusive to osteoarthritis
grade-b Notable Very High See all 15 studies
There decreases in pain associated with curcumin at higher doses which extend to post-operative, arthritis, and general pain symptoms. In particular, curcumin has been researched for osteoarthritis the most, but many of these studies are of low quality and funded by industry, so caution is warranted.
grade-b Minor - See study
The pain associated with chronic venous insufficiency may be alleviated when that condition is treated by horse chestnut extract.

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By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.

Frequently Asked Questions and Articles on Pain

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Click here to see all 29 references.