NOTE: We are updating our coronavirus (COVID-19) page with evidence as it comes in.
Summary of Serrapeptase
Primary information, health benefits, side effects, usage, and other important details
Serrapeptase is a proteolytic (protein destroying) enzyme from bacteria native to the digestive system of silkworms. It is the enzyme responsible for dissolving a silkworm’s cocoon.
Traditionally, serrapeptase has been used for its anti-inflammatory properties. Today, it is marketed as a joint health supplement.
Unfortunately, many studies on serrapeptase were poorly structured, with inadequate control groups. The most recent data suggests that serrapeptase is not a very effective supplement, as far as joint health and inflammation is concerned.
Though serrapeptase has been detected in plasma after supplementation, the standard oral dose for serrapeptase is low, which means very little is absorbed through the intestines. This may be one of the reasons serrapeptase is unreliable and not very effective.
Serrapeptase has been found to have the ability to liquefy mucus and reduce bacterial biofilms (reducing bacteria’s ability to stick to surfaces and each other). This means serrapeptase may be able to reduce phlegm buildup, nasal discharge, lung symptoms of cystic fibrosis and help other compounds fight bacteria. Additional research is needed to confirm these effects.
Want to know which supplements you should take?
Examine.com bases all of its recommendations based on research. We’re a trusted resource because we don’t sell or even advertise supplements.
If you’re tired of wasting time and money on supplements that don’t work, our 17 Supplement Guides will help you figure out precisely what to take — and what to skip — based on your health goals and the latest scientific evidence. There’s a reason why over 50,000 customers rely on Examine.com’s independent and science-based analysis.
And best of all — free lifetime updates are included!
I want unbiased recommendations to improve my health »
How to TakeMedical Disclaimer
Recommended dosage, active amounts, other details
The standard dose for serrapeptase is 10-60mg.
Serrapeptase should be supplemented on an empty stomach, which is 30 minutes before a meal or two hours after a meal, three times a day. Most studies use 10mg of serrapeptase taken every eight hours.
More human evidence is needed to determine the optimal dose of serrapeptase. 10mg of serrapeptase is equal to approximately 20,000 enzymatic units.
Improve your health with the latest information on 400+ supplements and their effects on 600+ health outcomes.
By becoming an Examine Plus member, you'll have access to all of the latest nutrition research. Quickly and easily look up scientific research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.
Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects serrapeptase has on your body, and how strong these effects are.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Minor||High See all 4 studies|
|Minor||High See all 5 studies|
|Notable||Very High See all 4 studies|
|Minor||- See study|
|Minor||Very High See 2 studies|
|Minor||- See study|
|Minor||- See study|
Studies Excluded from Consideration
Confounded with paracetamol
Get access to the latest nutrition research summarized
By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.
Things to Note
Also Known As
Serratiopeptidase, Serratia E-15, serralysin, serratiaprotease, Serratiopeptidase, Silk worm enzymes
Goes Well With
Antibiotics (reduces biofilm on bacteria, and thus enhances the ability of antibiotics to act upon bacteria)
Due to potential fibrolytic activity, caution should be taken when pairing serrapeptase with moderately potent blood thinners (Fish Oil) and should not be paired with more potent blood thinners (Clopidogrel, Warfarin, Aspirin)
Serrapeptase, if it is to work, requires an enteric coated capsule
Tired of misinformation? Get unbiased info on supplements.
At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.
Join over 250,000 people who’ve learned about effective versus overrated supplements, supplement buying tips, and how to combine supplements for safety and efficacy.
Click here to see all 49 references.