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Nitric Oxide

Nitric oxide is a signalling molecule formed from nitrogen (N) and oxygen (O) and abbreviated as NO. It plays a major signaling role in vascular relaxation with implications for blood pressure regulation, and erectile function. It is also used by the immune symptom in the immune response, inflammation, and anti-thrombotic activity, as well as functioning as a neurotransmitter. It is synthesized from arginine and nitrates in the diet.

Our evidence-based analysis on nitric oxide features 22 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect nitric oxide.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 7 studies
Has been implicated in increasing nitric oxide formation in the body, but this does not appear to be a reliably occurring phenomena (despite arginine being required to make nitric oxide, it is not a good inducer thereof)
grade-c Notable Very High See 2 studies
Nitric oxide derivatives (nitrate and urinary cGMP, since nitric oxide itself is hard to measure these biomarkers are indicative of nitric oxide production) appear to be reliably increased following oral consumption of citrulline supplementation
grade-c Notable - See study
80mg of a bioavailability enhanced curcumin supplement has been reported to increase nitric oxide in serum by 40% or so, which is significantly larger than many other dietary supplements.

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Things to Note

Also Known As

NO

Click here to see all 22 references.