The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect nitric oxide.
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Supplement |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
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Minor
|
High See all 7 studies |
Has been implicated in increasing nitric oxide formation in the body, but this does not appear to be a reliably occurring phenomena (despite arginine being required to make nitric oxide, it is not a good inducer thereof)
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Notable
|
Very High See 2 studies |
Nitric oxide derivatives (nitrate and urinary cGMP, since nitric oxide itself is hard to measure these biomarkers are indicative of nitric oxide production) appear to be reliably increased following oral consumption of citrulline supplementation
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Notable
|
- See study |
80mg of a bioavailability enhanced curcumin supplement has been reported to increase nitric oxide in serum by 40% or so, which is significantly larger than many other dietary supplements.
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