A recommended dosage is 10-20mg, taken thrice a day.
Acute dosages of 50mg are also frequently used, although not thrice a day.
Synephrine
How to Take
Recommended dosage, active amounts, other details
Easily stay on top of nutrition research
Become an Examine.com member to get access to the latest research. 150+ studies summarized across 25 different categories every month.
Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes.
Already a member? Click here to log in.
Make informed decisions about your health
Human Effect Matrix
Unlocked for Examine members
The Human Effect Matrix summarizes human studies to tell you what effects Synephrine has on your body, how much evidence there is, and how strong these effects are.
Full details are available to Examine members.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
|
Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
|
|
|
- | - See study |
|
Studies Excluded from Consideration
Stay on top of the latest research
Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. Information tailored to you, updated every month.
Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com.
Things to Note
Is a Form Of
Other Functions:
Primary Function:
Also Known As
Bitter Orange, p-synephrine, Citrus Aurantium
Do Not Confuse With
Goes Well With
Naringenin and, possibly, Hesperidin
P-synephrine is stimulatory
At this moment in time, p-synephrine does not appear to cause a false positive on a CEDIA amphetamine urine test
Synephrine is allowed by WADA, but its metabolite octopamine is not; supplementation of synephrine does not appear to significantly increase urinary octopamine
Get our free 5-day course on the essentials of supplementation.
At Examine.com, our incentives line up with yours — getting unbiased information. That's why we don’t sell any advertising or supplements.
Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy.
Click here to see all 34 references.
