Synephrine
A recommended dosage is 10-20mg, taken thrice a day.
Acute dosages of 50mg are also frequently used, although not thrice a day.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects synephrine has on your body, and how strong these effects are.
| Grade | Level of Evidence [show legend] |
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
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The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Outcome |
Magnitude of effect
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The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
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Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
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Studies Excluded from Consideration
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Things to Note
Is a Form Of
Other Functions:
Primary Function:
Also Known As
Bitter Orange, p-synephrine, Citrus Aurantium
Do Not Confuse With
Goes Well With
Naringenin and, possibly, Hesperidin
P-synephrine is stimulatory
At this moment in time, p-synephrine does not appear to cause a false positive on a CEDIA amphetamine urine test
Synephrine is allowed by WADA, but its metabolite octopamine is not; supplementation of synephrine does not appear to significantly increase urinary octopamine
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