Phenylethylamine

Last Updated: September 28 2022

A trace amine and influencer of many of the 'happy hormones' such as dopamine and serotonin, β-phenylethylamine is an important molecule in the brain with limited supplemental usage due to being rapidly broken down into inactive components.

Phenylethylamine is most often used for

What else is Phenylethylamine known as?
Note that Phenylethylamine is also known as:
  • PEA
  • β-phenylethylamine
  • phenethylamine
  • β-phenethylamine
  • Benzeneethanamine

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References
1.^Irsfeld M, Spadafore M, Prüß BMβ-phenylethylamine, a small molecule with a large impactWebmedcentral.(2013 Sep 30)
2.^Premont RT1, Gainetdinov RR, Caron MGFollowing the trace of elusive aminesProc Natl Acad Sci U S A.(2001 Aug 14)
3.^Güven KC1, Percot A, Sezik EAlkaloids in marine algaeMar Drugs.(2010 Feb 4)
4.^Kim B1, Byun BY, Mah JHBiogenic amine formation and bacterial contribution in Natto productsFood Chem.(2012 Dec 1)
5.^Figueiredo TC1, Viegas RP, Lara LJ, Baião NC, Souza MR, Heneine LG, Cançado SVBioactive amines and internal quality of commercial eggsPoult Sci.(2013 May)
7.^Janssen PA1, Leysen JE, Megens AA, Awouters FHDoes phenylethylamine act as an endogenous amphetamine in some patientsInt J Neuropsychopharmacol.(1999 Sep)
8.^Flydal MI1, Martinez APhenylalanine hydroxylase: function, structure, and regulationIUBMB Life.(2013 Apr)
9.^Mitchell JJ1, Trakadis YJ, Scriver CRPhenylalanine hydroxylase deficiencyGenet Med.(2011 Aug)
11.^Guldberg P1, Güttler FMutations in the phenylalanine hydroxylase gene: methods for their characterizationActa Paediatr Suppl.(1994 Dec)
12.^Eisensmith RC1, Martinez DR, Kuzmin AI, Goltsov AA, Brown A, Singh R, Elsas LJ II, Woo SLMolecular basis of phenylketonuria and a correlation between genotype and phenotype in a heterogeneous southeastern US populationPediatrics.(1996 Apr)
13.^CAMP BJ, LYMAN CMThe isolation of N-methyl beta-phenylethylamine from Acacia berlandieriJ Am Pharm Assoc Am Pharm Assoc (Baltim).(1956 Nov)
15.^Shannon HE, Cone EJ, Yousefnejad DPhysiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dogJ Pharmacol Exp Ther.(1982 Oct)
16.^Lindemann L1, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MCTrace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptorsGenomics.(2005 Mar)
18.^Borowsky B1, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald CTrace amines: identification of a family of mammalian G protein-coupled receptorsProc Natl Acad Sci U S A.(2001 Jul 31)
19.^Wainscott DB1, Little SP, Yin T, Tu Y, Rocco VP, He JX, Nelson DLPharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1J Pharmacol Exp Ther.(2007 Jan)
20.^Miller GM1, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BKPrimate trace amine receptor 1 modulation by the dopamine transporterJ Pharmacol Exp Ther.(2005 Jun)
21.^Bunzow JR1, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DKAmphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptorMol Pharmacol.(2001 Dec)
22.^Xie Z1, Vallender EJ, Yu N, Kirstein SL, Yang H, Bahn ME, Westmoreland SV, Miller GMCloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic associationJ Neurosci Res.(2008 Nov 15)
23.^Barak LS1, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RRPharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensorMol Pharmacol.(2008 Sep)
25.^Babusyte A1, Kotthoff M, Fiedler J, Krautwurst DBiogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2J Leukoc Biol.(2013 Mar)
26.^Kleinau G1, Pratzka J, Nürnberg D, Grüters A, Führer-Sakel D, Krude H, Köhrle J, Schöneberg T, Biebermann HDifferential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonistsPLoS One.(2011)
29.^Hjorth S1, Bengtsson HJ, Kullberg A, Carlzon D, Peilot H, Auerbach SBSerotonin autoreceptor function and antidepressant drug actionJ Psychopharmacol.(2000 Jun)
31.^Durden DA, Philips SR, Boulton AAIdentification and distribution of beta-phenylethylamine in the ratCan J Biochem.(1973 Jul)
34.^Mosnaim AD1, Callaghan OH, Hudzik T, Wolf MERat brain-uptake index for phenylethylamine and various monomethylated derivativesNeurochem Res.(2013 Apr)
42.^Saavedra JM, Axelrod JDemonstration and distribution of phenylethanolamine in brain and other tissuesProc Natl Acad Sci U S A.(1973 Mar)
43.^Ziegler MG1, Bao X, Kennedy BP, Joyner A, Enns RLocation, development, control, and function of extraadrenal phenylethanolamine N-methyltransferaseAnn N Y Acad Sci.(2002 Oct)
44.^Wu Q1, McLeish MJKinetic and pH studies on human phenylethanolamine N-methyltransferaseArch Biochem Biophys.(2013 Nov 1)
47.^Levitt P, Pintar JE, Breakefield XOImmunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neuronsProc Natl Acad Sci U S A.(1982 Oct)
48.^Ma G1, Bavadekar SA, Schaneberg BT, Khan IA, Feller DREffects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypesPlanta Med.(2010 Jul)
50.^Sotnikova TD1, Budygin EA, Jones SR, Dykstra LA, Caron MG, Gainetdinov RRDopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamineJ Neurochem.(2004 Oct)
52.^Ishida K1, Murata M, Katagiri N, Ishikawa M, Abe K, Kato M, Utsunomiya I, Taguchi KEffects of beta-phenylethylamine on dopaminergic neurons of the ventral tegmental area in the rat: a combined electrophysiological and microdialysis studyJ Pharmacol Exp Ther.(2005 Aug)
53.^Liang NY, Rutledge COEvidence for carrier-mediated efflux of dopamine from corpus striatumBiochem Pharmacol.(1982 Aug 1)
54.^Raiteri M, Bertollini A, del Carmine R, Levi GEffects of phenethylamine derivatives on the release of biogenic amines from synaptosomesBiochem Soc Trans.(1976)
56.^Mercuri NB1, Saiardi A, Bonci A, Picetti R, Calabresi P, Bernardi G, Borrelli ELoss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient miceNeuroscience.(1997 Jul)
59.^Grabowski J1, Rhoades H, Schmitz J, Stotts A, Daruzska LA, Creson D, Moeller FGDextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trialJ Clin Psychopharmacol.(2001 Oct)
60.^Daw ND1, Kakade S, Dayan POpponent interactions between serotonin and dopamineNeural Netw.(2002 Jun-Jul)
63.^Rothman RB1, Blough BE, Baumann MHDopamine/serotonin releasers as medications for stimulant addictionsProg Brain Res.(2008)
65.^Szabo A1, Billett E, Turner JPhenylethylamine, a possible link to the antidepressant effects of exerciseBr J Sports Med.(2001 Oct)
66.^Nelson DA1, Tolbert MD, Singh SJ, Bost KLExpression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytesJ Neuroimmunol.(2007 Dec)
69.^Becú-Villalobos D1, Thyssen SM, Rey EB, Lux-Lantos V, Libertun COctopamine and phenylethylamine inhibit prolactin secretion both in vivo and in vitroProc Soc Exp Biol Med.(1992 Feb)
70.^Becú-Villalobos D, Vacas MI, Libertun CProlactin inhibition by p-tyramine in the male rat: site of actionEndocrinology.(1987 Jun)
71.^Ben-Jonathan N1, Hnasko RDopamine as a prolactin (PRL) inhibitorEndocr Rev.(2001 Dec)
72.^Sterling NW1, Du G, Lewis MM, Dimaio C, Kong L, Eslinger PJ, Styner M, Huang XStriatal shape in Parkinson's diseaseNeurobiol Aging.(2013 Nov)
75.^Zhou G1, Shoji H, Yamada S, Matsuishi TDecreased beta-phenylethylamine in CSF in Parkinson's diseaseJ Neurol Neurosurg Psychiatry.(1997 Dec)
78.^Finberg JP1, Gillman KSelective inhibitors of monoamine oxidase type B and the "cheese effect"Int Rev Neurobiol.(2011)
79.^Wimbiscus M1, Kostenko O, Malone DMAO inhibitors: risks, benefits, and loreCleve Clin J Med.(2010 Dec)
80.^Johnson LA1, Furman CA, Zhang M, Guptaroy B, Gnegy MERapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulationNeuropharmacology.(2005 Nov)
82.^Saunders C1, Ferrer JV, Shi L, Chen J, Merrill G, Lamb ME, Leeb-Lundberg LM, Carvelli L, Javitch JA, Galli AAmphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanismProc Natl Acad Sci U S A.(2000 Jun 6)
83.^Fleckenstein AE1, Haughey HM, Metzger RR, Kokoshka JM, Riddle EL, Hanson JE, Gibb JW, Hanson GRDifferential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter functionEur J Pharmacol.(1999 Oct 1)