Muscle Damage
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect muscle damage
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
|---|---|---|---|---|
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Notable
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High See all 3 studies |
Decrease creatine kinase exists following acute supplementation (15-30 minutes before a workout) of HMB free acid to about a third of control, and is effective in trained individuals
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Minor
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Moderate See all 6 studies |
Not overly protective, but there appears to be a degree of protection.
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Minor
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Very High See all 4 studies |
Biomarkers of muscle damage including creatine kinase and muscle soreness are both fairly reliably reduced following ingestion of carnitine and pairing with exercise
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