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Growth Hormone

Growth hormone (GH) is a peptide hormone that regulates growth in youth, and in adults is thought to promote fat loss and longevity. Increasing growth hormone should improve these goals, but supplements are currently lacklustre.

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Things To Know & Note

Also Known As

GH

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect growth hormone
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Arginine
Minor
- See all 5 studies
Arginine has been implicated in increasing growth hormone (at rest) and suppressing an exercise-induced increase in growth hormone; both of these are short in duration, and it is unsure if there are any long lasting effects of such short a spike.
grade-c Creatine
Notable
- See all 4 studies
During exercise, creatine supplementation can suppress growth hormone secretion: up to 35% during loading; up to 5% during maintenance. At rest, creatine supplementation can spike growth hormone by up to 83±45%. This bidirectional effect is similar to that of arginine supplementation.
grade-c Alpha-GPC Minor Very High See 2 studies
Has noted an increase in circulating growth hormone, but measurements were acute (whole-day measurements of growth hormone are more reliable due to hourly fluctuations)
grade-c Citrulline  
grade-c Melatonin  
grade-c Nicotine  
grade-c Alanylglutamine  
grade-c Beta-Alanine  
grade-c Gamma Oryzanol  
grade-c HMB  
grade-c Trimethylglycine  
grade-c Velvet Antler  
grade-d Alcohol  
grade-d Dehydroepiandrosterone  
grade-d Colostrum  
grade-d Phosphatidylserine  
grade-d Vitamin B6  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.