Growth Hormone Research Analysis

Things To Know & Note

GH

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect growth hormone

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Arginine	Minor	- See all 5 studies	Arginine has been implicated in increasing growth hormone (at rest) and suppressing an exercise-induced increase in growth hormone; both of these are short in duration, and it is unsure if there are any long lasting effects of such short a spike.
Creatine	Notable	- See all 4 studies	During exercise, creatine supplementation can suppress growth hormone secretion: up to 35% during loading; up to 5% during maintenance. At rest, creatine supplementation can spike growth hormone by up to 83±45%. This bidirectional effect is similar to that of arginine supplementation.
Alpha-GPC	Minor	Very High See 2 studies	Has noted an increase in circulating growth hormone, but measurements were acute (whole-day measurements of growth hormone are more reliable due to hourly fluctuations)
Citrulline
Melatonin
Nicotine
Alanylglutamine
Beta-Alanine
Gamma Oryzanol
HMB
Trimethylglycine
Velvet Antler
Alcohol
Dehydroepiandrosterone
Colostrum
Phosphatidylserine
Vitamin B6

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.