Depression

Depression is a cognitive state associated with hopelessness and apathy. Clinical depression is a realm for medical doctors to address, but subclinical ennui might be counteracted with some supplements. Consider physical exercise as well, it might help a little.


Research analysis by and verified by the Examine.com Research Team. Last updated on Apr 29, 2017.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect depression

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
Fish Oil
All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.
The evidence for each separate supplement is still freely available ​here.
Saffron  
Curcumin  
Zinc  
Chromium  
Folic Acid  
Inositol  
Creatine  
Red Clover Extract  
Rhodiola Rosea  
S-Adenosyl Methionine  
Ashwagandha  
Bacopa monnieri  
Centella asiatica  
Ganoderma lucidum  
Kava  
Maca  
Panax ginseng  
Vitex agnus castus  
Yamabushitake  
Dehydroepiandrosterone  
Ginkgo biloba  
L-Tyrosine  
Marijuana  
N-Acetylcysteine  
Nefiracetam  
Nicotine  
Vitamin C  
Agmatine  
Holy Basil  
Lavender  
Magnesium  
Phenylpiracetam  
Royal Jelly  
Uridine  
Vitamin B12  
Vitamin D