Cyanocobalamin (Vitamin B12)

Last Updated: February 22, 2024

Cobalamin (Vitamin B12) is a water-soluble essential vitamin that is known to play roles in neurology.

Cyanocobalamin (Vitamin B12) is most often used for

What else is Cyanocobalamin (Vitamin B12) known as?
Note that Cyanocobalamin (Vitamin B12) is also known as:
  • Cyanocobalamin
  • methylcobalamin
  • 5-deoxyadenosylcobalamin
  • adenosylcobalamin
  • cobamamide
  • dibencozide
  • hydroxocobalamin
  • Cobalamin
  • vitamin b12
Dosage information

2.4 mcgs per day is the RDA for adults, generally (more is needed in some circumstances such as pregnancy). 100 mcg seems top be sufficient to reduce homocysteine for those with deficiency. Supplementation of vitamin B12 tends to be around 1,000 mcg (1 mg) of supplemental vitamin B12 to persons who are at risk for B12 insufficient or deficiency, mostly older individuals and vegans, though this dose is best only used for short periods with monitoring of levels so as to avoid excessive dosing and the potential risks.

Examine Database: Cyanocobalamin (Vitamin B12)
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References
  1. ^Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJMitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolismChem Biol Interact.(2006 Oct 27)
  2. ^Selhub JFolate, vitamin B12 and vitamin B6 and one carbon metabolismJ Nutr Health Aging.(2002)
  3. ^Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DLA Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer ChemopreventionN Engl J Med.(2015 Oct 22)
  4. ^Brasky TM, White E, Chen CLLong-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) CohortJ Clin Oncol.(2017 Oct 20)
  5. ^White E, Patterson RE, Kristal AR, Thornquist M, King I, Shattuck AL, Evans I, Satia-Abouta J, Littman AJ, Potter JDVITamins And Lifestyle cohort study: study design and characteristics of supplement usersAm J Epidemiol.(2004 Jan 1)
  6. ^Kim YIFolate and colorectal cancer: an evidence-based critical reviewMol Nutr Food Res.(2007 Mar)
  7. ^Kok DE, Dhonukshe-Rutten RA, Lute C, Heil SG, Uitterlinden AG, van der Velde N, van Meurs JB, van Schoor NM, Hooiveld GJ, de Groot LC, Kampman E, Steegenga WTThe effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjectsClin Epigenetics.(2015 Nov 14)
  8. ^Corbin JM, Ruiz-Echevarría MJOne-Carbon Metabolism in Prostate Cancer: The Role of Androgen SignalingInt J Mol Sci.(2016 Jul 27)
Examine Database References
  1. Fatigue Symptoms - Huijts M, van Oostenbrugge RJ, Rouhl RP, Menheere P, Duits AEffects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar strokeInt Psychogeriatr.(2013 Mar)
  2. Homocysteine - Hill MH, Flatley JE, Barker ME, Garner CM, Manning NJ, Olpin SE, Moat SJ, Russell J, Powers HJA vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 statusJ Nutr.(2013 Feb)