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Lion's Mane

Lion's Mane, known as Yamabushitake, is a dietary mushroom that can be a supplement. It appears to be a promising cognitive enhancer and immunomodulator (thought to stimulate or suppress inflammation depending on context).

Our evidence-based analysis on lion's mane features 44 unique references to scientific papers.

Research analysis led by .
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Last Updated:

How to Take

Recommended dosage, active amounts, other details

Currently, the only human study has used an oral dose of 1,000mg Lion's Mane (96% purity extract) thrice daily for a cumulative total of 3,000mg extract. While it is unknown if this is the optimal dose or not, it appeared to be effective.

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Human Effect Matrix

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The Human Effect Matrix summarizes human studies to tell you what effects Lion's Mane has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor - See study
Decreases in anxiety noted, this may be secondary to menopausal symptom reduction
grade-c Minor - See study
The rate of cognitive decline seen with oral supplementation of yamabushitake appears to be significantly reduced in older persons, although there are no direct comparisons to reference drugs at this time to assess potency.
grade-c Minor - See study
Decrease in depressive symptoms has been noted, which may be secondary to attenuating menopausal symptoms
grade-c Minor - See study
Menopausal symptoms have been reduced, but this was mostly due to the reported antidepressant and anxiolytic properties of the mushroom.
grade-c - - See study
No significant effects on sleep quality

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Things to Note

Other Functions:

Also Known As

Hericium erinaceus, Monkey's Head, Houtou (infrequent), Igelstachelbart, Pom Pom Blanc, Hedgehog Mushroom, Satyr’s Beard, Yamabushitake

  • As the water soluble extract seems to be less potent than other fractions, it may be best to take Yamabushitake with meals if in supplemental form

  • If itchy skin occurs, this may be related to an increase in Nerve Growth Factor[1] and unless accompanied by signs of allergy should be benign

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Click here to see all 44 references.