Lion's Mane
•Last Updated: September 28 2022
Lion's Mane, known as Yamabushitake, is a dietary mushroom that can be a supplement. It appears to be a promising cognitive enhancer and immunomodulator (thought to stimulate or suppress inflammation depending on context).
Lion's Mane is most often used for
Last Updated: September 28 2022
Note that Lion's Mane is also known as:
- Hericium erinaceus
- Monkey's Head
- Houtou (infrequent)
- Igelstachelbart
- Pom Pom Blanc
- Hedgehog Mushroom
- Satyr’s Beard
- Yamabushitake
Currently, the only human study has used an oral dose of 1,000 mg Lion's Mane (96% purity extract) thrice daily for a cumulative total of 3,000 mg extract. While it is unknown if this is the optimal dose or not, it appeared to be effective.
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1.^Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata NNerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cellsBiol Pharm Bull.(2008 Sep)
2.^Wong KH, Naidu M, David RP, Bakar R, Sabaratnam VNeuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review)Int J Med Mushrooms.(2012)
3.^Bioactive Substances in YAMABUSHITAKE, the Hericium erinaceum Fungus, and its Medicinal Utilization
4.^Yaoita Y, Danbara K, Kikuchi MTwo new aromatic compounds from Hericium erinaceum (BULL.: FR.) PERS(1)Chem Pharm Bull (Tokyo).(2005 Sep)
6.^Ueda K, Tsujimori M, Kodani S, Chiba A, Kubo M, Masuno K, Sekiya A, Nagai K, Kawagishi HAn endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceumBioorg Med Chem.(2008 Nov 1)
8.^Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum
11.^Li JL, Lu L, Dai CC, Chen K, Qiu JYA comparative study on sterols of ethanol extract and water extract from Hericium erinaceusZhongguo Zhong Yao Za Zhi.(2001 Dec)
12.^Mizuno T, Wasa T, Ito H, Suzuki C, Ukai NAntitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtouBiosci Biotechnol Biochem.(1992 Feb)
13.^Xu H, Wu PR, Shen ZY, Chen XDChemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activitiesInt J Biol Macromol.(2010 Jul 1)
14.^Lee JS, Min KM, Cho JY, Hong EKStudy of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceusJ Microbiol Biotechnol.(2009 Sep)
15.^Dong Q, Jia LM, Fang JNA beta-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformationCarbohydr Res.(2006 May 1)
16.^Han ZH, Ye JM, Wang GFEvaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharidesInt J Biol Macromol.(2013 Jan)
17.^Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BFEvaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory ActivitiesEvid Based Complement Alternat Med.(2012)
18.^Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus ( Bull .: Fr .) Pers . Extracts
19.^Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum
20.^Neurotropic and Trophic Action of Lion's Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) Extracts on Nerve Cells in Vitro
21.^Ueda K, Kodani S, Kubo M, Masuno K, Sekiya A, Nagai K, Kawagishi HEndoplasmic reticulum (ER) stress-suppressive compounds from scrap cultivation beds of the mushroom Hericium erinaceumBiosci Biotechnol Biochem.(2009 Aug)
22.^Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GGThe influence of Hericium erinaceus extract on myelination process in vitroFiziol Zh.(2003)
23.^Mori K, Obara Y, Moriya T, Inatomi S, Nakahata NEffects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in miceBiomed Res.(2011 Feb)
24.^Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida TImproving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trialPhytother Res.(2009 Mar)
25.^Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki KReduction of depression and anxiety by 4 weeks Hericium erinaceus intakeBiomed Res.(2010 Aug)
26.^Wong KH, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, Sabaratnam VPeripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)Evid Based Complement Alternat Med.(2011)
27.^Activity of Aqueous Extracts of Lion's Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) on the Neural Cell Line NG108-15
28.^Farndale RW, Sixma JJ, Barnes MJ, de Groot PGThe role of collagen in thrombosis and hemostasisJ Thromb Haemost.(2004 Apr)
29.^Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, Inatomi S, Oshima Y, Nakahata NInhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregationPhytomedicine.(2010 Dec 1)
31.^Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum
32.^Hagiwara SY, Takahashi M, Shen Y, Kaihou S, Tomiyama T, Yazawa M, Tamai Y, Sin Y, Kazusaka A, Terazawa MA phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive ratsBiosci Biotechnol Biochem.(2005 Aug)
33.^Inhibitory effects of l-pipecolic acid from the edible mushroom, Sarcodon aspratus, on angiotensin I-converting enzyme
34.^Antioxidative and ACE inhibitory activities in enzymatic hydrolysates of the cotton leafworm, Spodoptera littoralis
35.^Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai MYamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat dietBiosci Biotechnol Biochem.(2010)
36.^Yang BK, Park JB, Song CHHypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceusBiosci Biotechnol Biochem.(2003 Jun)
37.^Kim YO, Lee SW, Oh CH, Rhee YHHericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophagesImmunopharmacol Immunotoxicol.(2011 Nov 29)
38.^Wang JC, Hu SH, Su CH, Lee TMAntitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium sppKaohsiung J Med Sci.(2001 Sep)
39.^Abdulla MA, Fard AA, Sabaratnam V, Wong KH, Kuppusamy UR, Abdullah N, Ismail SPotential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in ratsInt J Med Mushrooms.(2011)
40.^Kim SP, Nam SH, Friedman MHericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted miceJ Agric Food Chem.(2013 May 22)
41.^Park ID, Yoo HS, Lee YW, Son CG, Kwon M, Sung HJ, Cho CKToxicological study on MUNOPHIL, water extract of Panax ginseng and Hericium erinaceum in ratsJ Acupunct Meridian Stud.(2008 Dec)
42.^Nakatsugawa M, Takahashi H, Takezawa C, Nakajima K, Harada K, Sugawara Y, Kobayashi S, Kondo T, Abe SHericium erinaceum (yamabushitake) extract-induced acute respiratory distress syndrome monitored by serum surfactant proteinsIntern Med.(2003 Dec)