Which ingredients may help with low testosterone and erectile dysfunction? Original paper

Low testosterone and erectile dysfunction are common problems for men, and the market is awash with supplements claiming to treat them. However, the ingredients in those supplements are often not supported by science.

This was a systematic review of 105 randomized controlled trials of ingredients for low testosterone and erectile dysfunction. The ingredients were given grades of A (multiple randomized controlled trials showed a clear benefit), B (at least one trial showed a clear benefit), C (the trials were 50–50), and D (most of the evidence doesn’t suggest a benefit).

For low testosterone: A (Eurycoma longifolia Jack, Tribulus terrestris), B (Mucuna pruriens), C (arginine, aspartate, boron, citrulline, fenugreek, maca, and zinc), D (cayenne pepper, DIM, magnesium, nettle leaf, sarsaparilla, and vitamin B_₆). For erectile dysfunction: A (arginine, Eurycoma longifolia, horny goat weed, panax ginseng, yohimbine), B (Butea superba, fenugreek, Kaempferia parviflora, maca), C (saw palmetto, Tribulus terrestris), D (ashwagandha, Cnidium monnieri, dimethylglycine, fo-ti, Mucuna pruriens, Muira puama, NADH, polypodium vulgare, sarsaparilla, xanthoparmelia scabrosa).

Not all supplements that have ever been tested for low testosterone or erectile dysfunction were included, only those in a sample of products from popular brands.