Cnidium monnieri

Last Updated: November 17 2022

A pro-erectile herb from traditional Chinese medicine, Cnidium monnieri and its main bioactive known as osthole appear to have mechanisms similar to Viagra in penile tissue and the hippocampus; the influence of Cnidium monnieri on testosterone and cognition remains unexplored.

Cnidium monnieri is most often used for

What else is Cnidium monnieri known as?
Note that Cnidium monnieri is also known as:
  • Shechuangzi
  • Osthole
  • Jashoshi
  • Cnidii Fructus (Fruits of Cnidium)
Cnidium monnieri should not be confused with:
  • Bacopa Monneri
  • Cnidium Officinale (both similar but different plants)
Dosage information

Since there is no information on Osthole consumption in isolation, the best lead currently is the dose of Cnidium fruits or seeds used in Traditional Medicine; which is 6-15g of either fruit or seed

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5.^Dien PH, Nhan NT, Le Thuy HT, Quang DNMain constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activityNat Prod Res.(2011 Oct 21)
10.^Oh H, Kim JS, Song EK, Cho H, Kim DH, Park SE, Lee HS, Kim YCSesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cellsPlanta Med.(2002 Aug)
11.^Zhao J, Zhou M, Liu Y, Zhang G, Luo YChromones and coumarins from the dried fructus of Cnidium monnieriFitoterapia.(2011 Jul)
12.^Okamoto T, Kobayashi T, Yoshida SSynthetic derivatives of osthole for the prevention of hepatitisMed Chem.(2007 Jan)
13.^Teng CM, Lin CH, Ko FN, Wu TS, Huang TFThe relaxant action of osthole isolated from Angelica pubescens in guinea-pig tracheaNaunyn Schmiedebergs Arch Pharmacol.(1994 Feb)
14.^You L, An R, Wang X, Li YDiscovery of novel osthole derivatives as potential anti-breast cancer treatmentBioorg Med Chem Lett.(2010 Dec 15)
24.^Kummer O, Hammann F, Moser C, Schaller O, Drewe J, Krähenbühl SEffect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodoneEur J Clin Pharmacol.(2011 Jan)
26.^Lv X, Wang CY, Hou J, Zhang BJ, Deng S, Tian Y, Huang SS, Zhang HL, Shu XH, Zhen YH, Liu KX, Yao JH, Ma XCIsolation and identification of metabolites of osthole in ratsXenobiotica.(2012 May 26)
27.^Zhang J, Xue J, Wang H, Zhang Y, Xie MOsthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stressPhytother Res.(2011 May)
28.^Sun F, Xie ML, Zhu LJ, Xue J, Gu ZLInhibitory effect of osthole on alcohol-induced fatty liver in miceDig Liver Dis.(2009 Feb)
30.^Zhang Y, Xie ML, Zhu LJ, Gu ZLTherapeutic effect of osthole on hyperlipidemic fatty liver in ratsActa Pharmacol Sin.(2007 Mar)
34.^Lee WH, Lin RJ, Lin SY, Chen YC, Lin HM, Liang YCOsthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cellsJ Agric Food Chem.(2011 Dec 28)
35.^Lin VC, Chou CH, Lin YC, Lin JN, Yu CC, Tang CH, Lin HY, Way TDOsthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathwayJ Agric Food Chem.(2010 Apr 28)
39.^Yang D, Gu T, Wang T, Tang Q, Ma CEffects of osthole on migration and invasion in breast cancer cellsBiosci Biotechnol Biochem.(2010)
44.^Chen KK, Chan JY, Chang LS, Chen MT, Chan SHElicitation of penile erection following activation of the hippocampal formation in the ratNeurosci Lett.(1992 Jul 20)
46.^Singhuber J, Baburin I, Ecker GF, Kopp B, Hering SInsights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarinsEur J Pharmacol.(2011 Oct 1)
47.^Hsieh MT, Hsieh CL, Wang WH, Chen CS, Lin CJ, Wu CROsthole improves aspects of spatial performance in ovariectomized ratsAm J Chin Med.(2004)
49.^Liang HJ, Suk FM, Wang CK, Hung LF, Liu DZ, Chen NQ, Chen YC, Chang CC, Liang YCOsthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db miceChem Biol Interact.(2009 Oct 30)
53.^Chiou WF, Huang YL, Chen CF, Chen CCVasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosumPlanta Med.(2001 Apr)
57.^Tohda C, Kakihara Y, Komatsu K, Kuraishi YInhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch responseBiol Pharm Bull.(2000 May)
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61.^Ko FN, Wu TS, Liou MJ, Huang TF, Teng CMVasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescensEur J Pharmacol.(1992 Aug 14)