Cnidium monnieri
•Last Updated: November 17 2022
A pro-erectile herb from traditional Chinese medicine, Cnidium monnieri and its main bioactive known as osthole appear to have mechanisms similar to Viagra in penile tissue and the hippocampus; the influence of Cnidium monnieri on testosterone and cognition remains unexplored.
Cnidium monnieri is most often used for
Last Updated: November 17 2022
Note that Cnidium monnieri is also known as:
- Shechuangzi
- Osthole
- Jashoshi
- Cnidii Fructus (Fruits of Cnidium)
Cnidium monnieri should not be confused with:
- Bacopa Monneri
- Cnidium Officinale (both similar but different plants)
Since there is no information on Osthole consumption in isolation, the best lead currently is the dose of Cnidium fruits or seeds used in Traditional Medicine; which is 6-15g of either fruit or seed
Latest ResearchRead all studies
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3.^Lia HB, Chen FPreparative isolation and purification of bergapten and imperatorin from the medicinal plant Cnidium monnieri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phaseJ Chromatogr A.(2004 Dec 17)
4.^Wang SJ, Lin TY, Lu CW, Huang WJOsthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminalsNeurochem Int.(2008 Dec)
5.^Dien PH, Nhan NT, Le Thuy HT, Quang DNMain constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activityNat Prod Res.(2011 Oct 21)
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11.^Zhao J, Zhou M, Liu Y, Zhang G, Luo YChromones and coumarins from the dried fructus of Cnidium monnieriFitoterapia.(2011 Jul)
12.^Okamoto T, Kobayashi T, Yoshida SSynthetic derivatives of osthole for the prevention of hepatitisMed Chem.(2007 Jan)
13.^Teng CM, Lin CH, Ko FN, Wu TS, Huang TFThe relaxant action of osthole isolated from Angelica pubescens in guinea-pig tracheaNaunyn Schmiedebergs Arch Pharmacol.(1994 Feb)
14.^You L, An R, Wang X, Li YDiscovery of novel osthole derivatives as potential anti-breast cancer treatmentBioorg Med Chem Lett.(2010 Dec 15)
16.^Free radical scavenging activities of Cnidium officinale Makino and Ligusticum chuanxiong Hort. methanolic extracts.()
17.^Bae KE, Choi YW, Kim ST, Kim YKComponents of rhizome extract of Cnidium officinale Makino and their in vitro biological effectsMolecules.(2011 Oct 21)
18.^Zhou J, Wang SW, Sun XLDetermination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extractionAnal Chim Acta.(2008 Feb 11)
19.^Zhou J, Zeng P, Cheng ZH, Liu J, Wang FQ, Qian RJApplication of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasmaJ Chromatogr B Analyt Technol Biomed Life Sci.(2011 Aug 1)
20.^Yuan Z, Xu H, Wang K, Zhao Z, Hu MDetermination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MSJ Pharm Biomed Anal.(2009 Jul 12)
21.^Yang XW, Guo QM, Wang YAbsorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer modelZhong Xi Yi Jie He Xue Bao.(2008 Apr)
22.^Li Y, Meng F, Xiong Z, Liu H, Li FHPLC determination and pharmacokinetics of osthole in rat plasma after oral administration of Fructus Cnidii extractJ Chromatogr Sci.(2005 Sep)
23.^Shi J, Fu Q, Chen W, Yang HP, Liu J, Wang XM, He XComparative study of pharmacokinetics and tissue distribution of osthole in rats after oral administration of pure osthole and Libanotis buchtormensis supercritical extractJ Ethnopharmacol.(2012 Nov 6)
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26.^Lv X, Wang CY, Hou J, Zhang BJ, Deng S, Tian Y, Huang SS, Zhang HL, Shu XH, Zhen YH, Liu KX, Yao JH, Ma XCIsolation and identification of metabolites of osthole in ratsXenobiotica.(2012 May 26)
27.^Zhang J, Xue J, Wang H, Zhang Y, Xie MOsthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stressPhytother Res.(2011 May)
28.^Sun F, Xie ML, Zhu LJ, Xue J, Gu ZLInhibitory effect of osthole on alcohol-induced fatty liver in miceDig Liver Dis.(2009 Feb)
29.^Sun F, Xie ML, Xue J, Wang HBOsthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murinePhytomedicine.(2010 Jul)
30.^Zhang Y, Xie ML, Zhu LJ, Gu ZLTherapeutic effect of osthole on hyperlipidemic fatty liver in ratsActa Pharmacol Sin.(2007 Mar)
31.^Zhang Y, Xie ML, Xue J, Gu ZLOsthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver ratsJ Asian Nat Prod Res.(2008 Jul-Aug)
32.^Zhang Y, Xie M, Xue J, Gu ZOsthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expressionPlanta Med.(2007 Jul)
33.^Du R, Xue J, Wang HB, Zhang Y, Xie MLOsthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expressionEur J Pharmacol.(2011 Sep)
34.^Lee WH, Lin RJ, Lin SY, Chen YC, Lin HM, Liang YCOsthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cellsJ Agric Food Chem.(2011 Dec 28)
35.^Lin VC, Chou CH, Lin YC, Lin JN, Yu CC, Tang CH, Lin HY, Way TDOsthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathwayJ Agric Food Chem.(2010 Apr 28)
36.^Huang CH, Tsai SJ, Wang YJ, Pan MH, Kao JY, Way TDEGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cellsMol Nutr Food Res.(2009 Sep)
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39.^Yang D, Gu T, Wang T, Tang Q, Ma CEffects of osthole on migration and invasion in breast cancer cellsBiosci Biotechnol Biochem.(2010)
40.^Yu D, Hung MCOverexpression of ErbB2 in cancer and ErbB2-targeting strategiesOncogene.(2000 Dec 11)
41.^Lin TY, Lu CW, Huang WJ, Wang SJInvolvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endingsSynapse.(2012 Mar)
42.^Lin TY, Lu CW, Huang WJ, Wang SJOsthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endingsSynapse.(2010 May)
43.^Song Y, Rajasekaran MEffect of excitatory amino acid receptor agonists on penile erection after administration into the CA3 hippocampal region in the ratUrology.(2004 Dec)
44.^Chen KK, Chan JY, Chang LS, Chen MT, Chan SHElicitation of penile erection following activation of the hippocampal formation in the ratNeurosci Lett.(1992 Jul 20)
46.^Singhuber J, Baburin I, Ecker GF, Kopp B, Hering SInsights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarinsEur J Pharmacol.(2011 Oct 1)
47.^Hsieh MT, Hsieh CL, Wang WH, Chen CS, Lin CJ, Wu CROsthole improves aspects of spatial performance in ovariectomized ratsAm J Chin Med.(2004)
48.^Hardie DGThe AMP-activated protein kinase pathway--new players upstream and downstreamJ Cell Sci.(2004 Nov 1)
49.^Liang HJ, Suk FM, Wang CK, Hung LF, Liu DZ, Chen NQ, Chen YC, Chang CC, Liang YCOsthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db miceChem Biol Interact.(2009 Oct 30)
50.^Qi Z, Xue J, Zhang Y, Wang H, Xie MOsthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver ratsPlanta Med.(2011 Feb)
51.^Chen CYComputational screening and design of traditional Chinese medicine (TCM) to block phosphodiesterase-5J Mol Graph Model.(2009 Oct)
52.^Chen J, Chiou WF, Chen CC, Chen CFEffect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitroJ Urol.(2000 Jun)
53.^Chiou WF, Huang YL, Chen CF, Chen CCVasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosumPlanta Med.(2001 Apr)
54.^Yuan J, Xie J, Li A, Zhou FEffects of osthol on androgen level and nitric oxide synthase activity in castrate ratsZhong Yao Cai.(2004 Jul)
55.^Li XX, Hara I, Matsumiya TEffects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiolBiol Pharm Bull.(2002 Jun)
56.^Usuki SEffects of herbal components of tokishakuyakusan on progesterone secretion by corpus luteum in vitroAm J Chin Med.(1991)
57.^Tohda C, Kakihara Y, Komatsu K, Kuraishi YInhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch responseBiol Pharm Bull.(2000 May)
58.^Matsuda H, Ido Y, Hirata A, Ino Y, Naruto S, Amamiya T, Kubo MAntipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON)Biol Pharm Bull.(2002 Feb)
59.^Basnet P, Yasuda I, Kumagai N, Tohda C, Nojima H, Kuraishi Y, Komatsu KInhibition of itch-scratch response by fruits of Cnidium monnieri in miceBiol Pharm Bull.(2001 Sep)
60.^Matsuda H, Tomohiro N, Ido Y, Kubo MAnti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, ostholBiol Pharm Bull.(2002 Jun)
61.^Ko FN, Wu TS, Liou MJ, Huang TF, Teng CMVasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescensEur J Pharmacol.(1992 Aug 14)
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