Creatinine
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect creatinine.
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
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The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Supplement |
Magnitude of effect
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The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
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Notable
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Moderate See all 12 studies |
Creatine supplementation usually increases serum creatinine levels during the loading phase (but usually not during maintenance), since creatinine is the breakdown product of creatine. This is not indicative of kidney damage.
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- | Very High See all 3 studies |
No known influence on creatinine, a biomarker for kidney health.
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Minor
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- See study |
An increase in creatinine has been noted alongside weight loss; practical significance of this information is not known.
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Get access to the latest nutrition research summarized
By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.
Frequently Asked Questions and Articles on Creatinine
Is creatine safe for your kidneys?
In people with healthy kidneys, long-term creatine supplementation is safe, but there are no long-term creatine studies in people with kidney issues. For these people, using a low dose of creatine (if any) would be prudent.
Click here to see all 24 references.
