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Adiponectin is an adipokine (signalling molecule secreted from fat cells, like leptin) which positively influences glucose metabolism and fat loss. Increasing adiponectin levels are thought to result in fat loss and improved health.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect adiponectin
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Conjugated Linoleic Acid - High See all 3 studies
No alterations in adiponectin has been noted with CLA supplementation
grade-c Vitamin B3 (Niacin) Notable Very High See 2 studies
An increase in circulating adiponectin has been noted in subjects with health ailments (NAFLD or metabolic syndrome) to a moderate degree
grade-c Arginine Minor - See study
At least in persons with impaired glucose tolerance, an increase in adiponectin (and the adiponectin:leptin ratio) has been noted with supplemental L-arginine
grade-c Curcumin  
grade-c Garlic  
grade-c Green Tea Catechins  
grade-c Inositol  
grade-c Irvingia gabonensis  
grade-c L-Carnitine  
grade-c Melatonin  
grade-c Astaxanthin  
grade-c Chromium  
grade-c Cocoa Extract  
grade-c Coenzyme Q10  
grade-c Fish Oil  
grade-c Licorice  
grade-c Nigella sativa  
grade-c Rose Hip  
grade-c Trimethylglycine  
grade-c Vitamin K  
grade-d Coffee  
grade-d Blueberry  
grade-d Vitamin C  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.