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Uric Acid

Uric acid is a molecule (a byproduct of purine metabolism) that, in excessive levels, can contribute to gout and kidney stones. Despite this, uric acid is a potent antioxidant compound.


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect uric acid
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Creatine Minor Very High See 2 studies
A minor reduction has been observed.
grade-c Glutamine Minor - See study
An increase in serum urate has been noted in the range of 10-20% acutely, but attenuates with time and is likely not a concern within a week. Practical significance of this increase unknown.
grade-c L-Carnitine Minor - See study
A decrease in uric acid has been noted
grade-c Psyllium  
grade-c Cocoa Extract  
grade-c Cordyceps  
grade-c Ganoderma lucidum  
grade-c Gynostemma pentaphyllum  
grade-c Nigella sativa  
grade-c Quercetin  
grade-c Rooibos  
grade-c Vitamin B2  
grade-d Garlic  
grade-d Hibiscus sabdariffa  
grade-d Tetradecyl Thioacetic Acid  
grade-d Vitamin C  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 0 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of references for this page.

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