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Fatigue

A chronic lack of motivation and 'energy'/'vitality', Fatigue can be acutely countered by stimulants (not advisable for the long term) or may be slowly mended by other compounds like Reishi or CoQ10.

Our evidence-based analysis on fatigue features 2 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Frequently Asked Questions about Fatigue

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What is Adrenal Fatigue?

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect fatigue
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 8 studies
The decrease in fatigue appears to be quite strong and somewhat reliable when a low dose is given over a prolonged period of time or a high dose is given acutely; there is one study which has noted an increase in fatigue (relative to placebo) that needs to be expanded upon.
grade-b Notable High See all 7 studies
400 mg/kg/day in children and adolescents subject to traumatic brain injury reduces fatigue frequency from around 90% down to near 10%. Fatigue is also reduced, though to a lesser degree, in cases of sleep deprivation.
grade-b Notable Very High See all 6 studies
Fatigue is notably reduced with modafinil supplementation, particularly during instances of sleep deprivation or hypersomnia.

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References

  1. Li-Ng M, Kennedy L. Adrenal Insufficiency. J Surg Oncol. (2012)
  2. Salvatori R. Adrenal insufficiency. JAMA. (2005)