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A chronic lack of motivation and 'energy'/'vitality', Fatigue can be acutely countered by stimulants (not advisable for the long term) or may be slowly mended by other compounds like Reishi or CoQ10.

Our evidence-based analysis on fatigue features 2 unique references to scientific papers.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Frequently Asked Questions about Fatigue

What is Adrenal Fatigue?
How eating better can make you happier
Food and supplements that can help fight stress, fatigue, anxiety, depression, and help you sleep better.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect fatigue
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-a Rhodiola Rosea Notable Very High See all 8 studies
The decrease in fatigue appears to be quite strong and somewhat reliable when a low dose is given over a prolonged period of time or a high dose is given acutely; there is one study which has noted an increase in fatigue (relative to placebo) that needs to be expanded upon.
grade-b Creatine Notable High See all 7 studies
400 mg/kg/day in children and adolescents subject to traumatic brain injury reduces fatigue frequency from around 90% down to near 10%. Fatigue is also reduced, though to a lesser degree, in cases of sleep deprivation.
grade-b Modafinil Notable Very High See all 6 studies
Fatigue is notably reduced with modafinil supplementation, particularly during instances of sleep deprivation or hypersomnia.
grade-b Beta-Alanine  
grade-b Branched Chain Amino Acids  
grade-b Coenzyme Q10  
grade-b L-Carnitine  
grade-b Pelargonium sidoides  
grade-b Trimethylglycine  
grade-c Citrulline  
grade-c Colostrum  
grade-c Alanylglutamine  
grade-c Ashwagandha  
grade-c Caffeine  
grade-c Coleus forskohlii  
grade-c Curcumin  
grade-c Ganoderma lucidum  
grade-c Glycine  
grade-c Ornithine  
grade-c Phosphatidylserine  
grade-c Pyruvate  
grade-c Valeriana officinalis  
grade-c Vitamin C  
grade-c 7-Keto DHEA  
grade-c Choline  
grade-c Cocoa Extract  
grade-c Fish Oil  
grade-c HMB  
grade-c L-Tyrosine  
grade-c Marijuana  
grade-c Methylsulfonylmethane  
grade-c Quercetin  
grade-c Resveratrol  
grade-c Tribulus terrestris  
grade-d Melissa officinalis  
grade-d Pyrroloquinoline quinone  
grade-d D-Ribose  
grade-d Phenylpiracetam  
grade-d Spirulina  
grade-d Vitamin B12  
grade-d Vitex agnus castus  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.


  1. Li-Ng M, Kennedy L. Adrenal Insufficiency. J Surg Oncol. (2012)
  2. Salvatori R. Adrenal insufficiency. JAMA. (2005)