Quick Navigation

Fatigue

Fatigue is a lack of 'energy'/'vitality', oftentimes leading to a lack of motivation or impaired physical or mental performance. Fatigue can be due to impaired hormonal production and signalling involved in metabolism, sluggish energy metabolism, intense activity, or inadequate recovery, among other causes. It can be countered by stimulants, though that may not be a good idea for the long-term due to drug tolerance. Foods and supplements that reduce fatigue may do so through being or affecting hormones involved in energy metabolism, or participating in improving enegy metabolism.

Our evidence-based analysis on fatigue features 2 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Get the latest information on 400+ supplements and their effects on 500+ health outcomes.

By becoming an Examine Plus member, you'll have access to all of the latest nutrition research. Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect fatigue.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 8 studies
The decrease in fatigue appears to be quite strong and somewhat reliable when a low dose is given over a prolonged period of time or a high dose is given acutely; there is one study which has noted an increase in fatigue (relative to placebo) that needs to be expanded upon.
grade-b Notable High See all 7 studies
400 mg/kg/day in children and adolescents subject to traumatic brain injury reduces fatigue frequency from around 90% down to near 10%. Fatigue is also reduced, though to a lesser degree, in cases of sleep deprivation.
grade-b Notable Very High See all 6 studies
Fatigue is notably reduced with modafinil supplementation, particularly during instances of sleep deprivation or hypersomnia.

Become an Examine Plus member to view this information.

You can currently view 3 supplements as a non-member - becoming a member will give you access to 44 total supplements on fatigue.

Already a member? Login now to access.

grade-b  
grade-b  
grade-b  
grade-b  
grade-b  
grade-b  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  
grade-d  

Get access to the latest nutrition research

By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 300 supplements across over 500 different health goals, outcomes, conditions, and more.

Frequently Asked Questions and Articles on Fatigue

How eating better can make you happier
Food and supplements that can help fight stress, fatigue, anxiety, depression, and help you sleep better.
What is Adrenal Fatigue?
Click here to see all 2 references.