DNA Damage Research Analysis

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect dna damage

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Blueberry	Notable	Very High See all 4 studies	DNA damage appears to be acutely decreased following consumption of blueberries or its extracts (375mg anthocyanins or more) and tends to be in the range of a 20% reduction.
Vitamin E	-	High See all 3 studies	While most evidence suggests no influence on DNA damage, it is possible based on some studies that when vitamin E turns prooxidative that it may damage DNA.
Olive leaf extract	Notable	- See study	The one study to measure DNA damage (via 8-oxo-dGF as a biomarker) noted up to 50% reductions in mitochondrial and urine measurements; a fairly significant reduction.
Creatine
Curcumin
Eleutherococcus senticosus
Panax ginseng
Watercress
Chlorella
Citrulline
Conjugated Linoleic Acid
Fish Oil
Ganoderma lucidum
Glutathione
Sea Buckthorn
Vitamin C
Garlic
Melissa officinalis
Chromium

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.