Quick Navigation

Fat Loss

These supplements are used to reduce body fat mass and may act through a variety of mechanisms, but most are ineffective, insufficiently researched, or likely to be harmful.

Our evidence-based analysis on fat loss features 217 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Fat Loss Summary

The goal of any alleged fat loss compound is to increase the rate of fat loss. This can be achieved by increasing the overall metabolic rate, reducing the absorption of macronutrients during digestion, reducing the amount people eat, or increasing the rate at which fatty acids are released from fat cells. Some newer fat-burning compounds may also work via uncoupling, which is the process of creating heat from fatty acids inside a cell.

Most supplements sold for fat loss are either ineffective, insufficiently researched, or likely to be harmful. Stimulants can damage the cardiovascular system and cause sleep disturbances in high doses; increase the rate at which fatty acids are released from fat cells, which can worsen insulin sensitivity; and block the absorption of fats and carbohydrates, which can lead to unpleasant gastrointestinal symptoms. There may be some supplements that have meaningful effects with little downside, but this category of supplements should be used only with the utmost caution and scrutiny.

If you are looking for a list of supplements to take to help with fat loss, we recommend you look at our fat loss supplement stack page.

Are you looking to lose fat and lean out?

If you want direct and straightforward directions on what works and what's a waste, then you need our Supplement Guides.

  • What supplements work
  • What supplements are a waste of time
  • How you can make sure you buy the right ones for you
  • How to improve the efficacy of the supplements you do take

No fake reviews. No supplements to sell. Just an unbiased look at what supplements work. The Supplement Guides will save you from frustration and save you time and money.

I want science-based recommendations »

Things to Note

Also Known As

fat burning, fat burner, fat burners

Caution Notice

Although not applicable to all, many fat burners increase levels of adrenaline in the body and should be approached with caution for those suffering from cardiac ailments or high blood pressure.

Many fat-burners are also neurologically active, and caution should be taken when one also uses neurologically active compounds like anti-depressants, be they prescription medication or supplemental.

Are you looking to lose fat and lean out?

If you want direct and straightforward directions on what works and what's a waste, then you need our Supplement Guides.

  • What supplements work
  • What supplements are a waste of time
  • How you can make sure you buy the right ones for you
  • How to improve the efficacy of the supplements you do take

No fake reviews. No supplements to sell. Just an unbiased look at what supplements work. The Supplement Guides will save you from frustration and save you time and money.

I want science-based recommendations »
Click here to see all 217 references.