Quick Navigation

2,4-Dinitrophenol

A highly toxic yet effective fat burning compound; DNP works via increasing heat production in cells via a process known as uncoupling (making cells less efficient with energy) and small overdoses have been known to result in death.

Our evidence-based analysis on 2,4-dinitrophenol features 23 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Summary of 2,4-Dinitrophenol

Primary information, health benefits, side effects, usage, and other important details

Dinitrophenol is an ionophoric compound that short circuits mitochondrial ATP production. This cessation of ATP production via the mitochondria leads to an increase in the metabolic rate (as substrate is utilized at a higher rate so cytosolic ATP can sustain life) and subsequent weight loss.

It is one of the few chemical compounds that is causatively linked to death. Overdosing on Dinitrophenol leads to toxicity via excessive heat production, irregular breathing and heartrate, and mitochondrial dysfunction.

Make sure you only take supplements that work

Examine.com bases all of its recommendations on published scientific research. We’re a trusted resource because we don’t sell or even advertise supplements.

If you’re tired of wasting time and money on supplements that don’t work, our 17 Supplement Guides will help you figure out precisely what to take — and what to skip — based on your health goals and the latest scientific evidence. There’s a reason why over 50,000 customers rely on Examine.com’s independent and unbiased analysis.

Includes free lifetime updates so you always have the most accurate information.


I want unbiased recommendations to improve my health »

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Standard online protocols advice for titrating up towards a dose of 200-400 mg daily with cessation after 2 weeks of usage.

(NOTE: This dosing information is anecdotal in nature and is based on past human trials that were not conducted in a controlled fashion. No information exists in the scientific literature for the best dosages for weight loss.)

Things to Note

Is a Form Of

Primary Function:

Also Known As

Dinitrophenol, DNP, 2, 4-DNP, Dinitro, Dinosan, Dnoc, Nitrophen, Chemox, Aldifen, Mitcal

Caution Notice

High Toxicity with risk of acute death

  • Overdosing of this compound requires a surprisingly small excess

Tired of misinformation? Get unbiased info on supplements.

At Examine.com, our incentives line up with yours — getting unbiased information. It’s why we don’t sell any advertising or supplements.

Join over 250,000 people who’ve learned about effective versus overrated supplements, supplement buying tips, and how to combine supplements for safety and efficacy.

Click here to see all 23 references.