2,4-Dinitrophenol
Our evidence-based analysis on 2,4-dinitrophenol features 23 unique references to scientific papers.
NOTE: We are updating our coronavirus (COVID-19) page with evidence as it comes in.
Summary of 2,4-Dinitrophenol
Primary information, health benefits, side effects, usage, and other important details
Dinitrophenol is an ionophoric compound that short circuits mitochondrial ATP production. This cessation of ATP production via the mitochondria leads to an increase in the metabolic rate (as substrate is utilized at a higher rate so cytosolic ATP can sustain life) and subsequent weight loss.
It is one of the few chemical compounds that is causatively linked to death. Overdosing on Dinitrophenol leads to toxicity via excessive heat production, irregular breathing and heartrate, and mitochondrial dysfunction.
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Standard online protocols advice for titrating up towards a dose of 200-400 mg daily with cessation after 2 weeks of usage.
(NOTE: This dosing information is anecdotal in nature and is based on past human trials that were not conducted in a controlled fashion. No information exists in the scientific literature for the best dosages for weight loss.)
Things to Note
Is a Form Of
Primary Function:
Also Known As
Dinitrophenol, DNP, 2, 4-DNP, Dinitro, Dinosan, Dnoc, Nitrophen, Chemox, Aldifen, Mitcal
Caution Notice
High Toxicity with risk of acute death
Overdosing of this compound requires a surprisingly small excess
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Click here to see all 23 references.
