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2,4-Dinitrophenol (DNP)

DNP is a highly toxic yet effective fat-burning compound. It increases heat production in cells via uncoupling (i.e., by making the cells use energy less efficiently). It can affect different people very differently, so that even what was considered small doses have killed.

Our evidence-based analysis on 2,4-dinitrophenol (dnp) features 23 unique references to scientific papers.

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Summary of 2,4-Dinitrophenol (DNP)

Primary information, health benefits, side effects, usage, and other important details

Dinitrophenol is an ionophoric compound that short circuits mitochondrial ATP production. This cessation of ATP production via the mitochondria leads to an increase in the metabolic rate (as substrate is utilized at a higher rate so cytosolic ATP can sustain life) and subsequent weight loss.

It is one of the few chemical compounds that is causatively linked to death. Overdosing on Dinitrophenol leads to toxicity via excessive heat production, irregular breathing and heartrate, and mitochondrial dysfunction.

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How to Take

Recommended dosage, active amounts, other details

Standard online protocols advice for titrating up towards a dose of 200-400 mg daily with cessation after 2 weeks of usage.

(NOTE: This dosing information is anecdotal in nature and is based on past human trials that were not conducted in a controlled fashion. No information exists in the scientific literature for the best dosages for weight loss.)

Things to Note

Is a Form Of

Primary Function:

Also Known As

Dinitrophenol, DNP, 2, 4-DNP, Dinitro, Dinosan, Dnoc, Nitrophen, Chemox, Aldifen, Mitcal

Caution Notice

High Toxicity with risk of acute death

  • Overdosing of this compound requires a surprisingly small excess

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Click here to see all 23 references.