Studies that use pomegranate seed oil use 400mg of a 72% punicic acid seed oil. While this appears to be in the bioactive range of punicic acid, it is not known if this is an optimal dosage or not.
Punicic Acid
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Human Effect Matrix
Unlocked for Examine membersThe Human Effect Matrix summarizes human studies to tell you what effects Punicic Acid has on your body, how much evidence there is, and how strong these effects are.
Full details are available to Examine members.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
|
Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Minor
|
Moderate See 2 studies |
Although there are possible increases in HDL-C with punicic acid, this has not been noted all the time and may be unreliable
|
|
|
|
Minor
|
Moderate See 2 studies |
A possible slight reduction in triglycerides has been noted with pomegranate oil, but this appears to be unreliable
|
|
|
|
- | - See study |
No significant influence on fat mass by itself
|
|
|
|
- | - See study |
No significant influence on fasting insulin levels
|
|
|
|
- | - See study |
No significant alterations in insulin sensitivity noted
|
|
|
|
- | Very High See 2 studies |
No significant influences on LDL-C levels
|
|
|
|
- | - See study |
No significant influence on lean mass has been noted with punicic acid supplementation
|
|
|
|
- | - See study |
No significant influence on serum TNF-a levels
|
|
|
|
- | - See study |
No significant influence on total cholesterol levels
|
|
|
|
- | - See study |
No significant influence on weight has been noted
|
Studies Excluded from Consideration
NOTE: The above table includes studies on Pomegranate Seed Oil as Punicic Acid is the main bioactive. Water extracts of pomegranate such as juice is gathered on the Punicalagins page
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Things to Note
Is a Form Of
Primary Function:
Also Known As
Pomegranate Seed Oil
Do Not Confuse With
Pomegranates (the fruit the oil comes from), Punicalagins (polyphenols in pomegranates)
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