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Punicic Acid

Punicic Acid is the main fatty acid found in Pomegranate Seed Oil and found in Pomegranates, it may contribute to many of the health benefits associated with Pomegranates.

Our evidence-based analysis on punicic acid features 15 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

How to Take

Recommended dosage, active amounts, other details

Studies that use pomegranate seed oil use 400mg of a 72% punicic acid seed oil. While this appears to be in the bioactive range of punicic acid, it is not known if this is an optimal dosage or not.

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Human Effect Matrix

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The Human Effect Matrix summarizes human studies to tell you what effects Punicic Acid has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor Moderate See 2 studies
Although there are possible increases in HDL-C with punicic acid, this has not been noted all the time and may be unreliable
grade-c Minor Moderate See 2 studies
A possible slight reduction in triglycerides has been noted with pomegranate oil, but this appears to be unreliable
grade-c - - See study
No significant influence on fat mass by itself
grade-c - - See study
No significant influence on fasting insulin levels
grade-c - - See study
No significant alterations in insulin sensitivity noted
grade-c - Very High See 2 studies
No significant influences on LDL-C levels
grade-c - - See study
No significant influence on lean mass has been noted with punicic acid supplementation
grade-c - - See study
No significant influence on serum TNF-a levels
grade-c - - See study
No significant influence on total cholesterol levels
grade-c - - See study
No significant influence on weight has been noted

Studies Excluded from Consideration

NOTE: The above table includes studies on Pomegranate Seed Oil as Punicic Acid is the main bioactive. Water extracts of pomegranate such as juice is gathered on the Punicalagins page

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Things to Note

Is a Form Of

Also Known As

Pomegranate Seed Oil

Do Not Confuse With

Pomegranates (the fruit the oil comes from), Punicalagins (polyphenols in pomegranates)

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Click here to see all 15 references.