Last Updated: June 29 2022

Choline is a molecule mostly used for either its cognitive boosting properties (turning into acetylcholine, the learning neurotransmitter) or as a liver health agent, able to reduce liver fat. It's found in high amounts in eggs; the yolks in particular.

Choline is most often used for

What else is Choline known as?
Note that Choline is also known as:
  • Trimethylethanolamine
  • Choline Bitartrate
Choline should not be confused with:
Dosage information

Doses for choline vary significantly.

Typically a dose of 250mg to 500mg is used for general health purposes once daily.

For mechanisms through acetylcholine, the choline should be pulsed in high doses acutely as higher doses are partitioned to the brain to a greater extent. 1-2g is typically used.

Doses should be titrated to suit the individual, as too high of a dose at any given time may give the user a headache. It is suggested that doses start out at 50-100mg daily and that users adjust upwards in accordance with their tolerance.

Examine Database
2.^Ueland PMCholine and betaine in health and diseaseJ Inherit Metab Dis.(2011 Feb)
4.^Wallace JM, McCormack JM, McNulty H, Walsh PM, Robson PJ, Bonham MP, Duffy ME, Ward M, Molloy AM, Scott JM, Ueland PM, Strain JJCholine supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal womenBr J Nutr.(2012 Oct)
5.^Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SMDecreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy studyJAMA.(1995 Sep 20)
6.^al-Waiz M, Mikov M, Mitchell SC, Smith RLThe exogenous origin of trimethylamine in the mouseMetabolism.(1992 Feb)
7.^Lang DH, Yeung CK, Peter RM, Ibarra C, Gasser R, Itagaki K, Philpot RM, Rettie AEIsoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3Biochem Pharmacol.(1998 Oct 15)
8.^Zhang AQ, Mitchell SC, Smith RLDietary precursors of trimethylamine in man: a pilot studyFood Chem Toxicol.(1999 May)
9.^Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SLGut flora metabolism of phosphatidylcholine promotes cardiovascular diseaseNature.(2011 Apr 7)
10.^Rak K, Rader DJCardiovascular disease: the diet-microbe morbid unionNature.(2011 Apr 7)
11.^Davidson SFlagging flora: heart disease linkNature.(2011 Sep 7)
12.^Mayr MRecent highlights of metabolomics in cardiovascular researchCirc Cardiovasc Genet.(2011 Aug 1)
13.^Zeisel SH, Wishnok JS, Blusztajn JKFormation of methylamines from ingested choline and lecithinJ Pharmacol Exp Ther.(1983 May)
14.^Tang WH1, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SLIntestinal microbial metabolism of phosphatidylcholine and cardiovascular riskN Engl J Med.(2013 Apr 25)
15.^Jiang X, Yan J, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Caudill MAMaternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humansFASEB J.(2012 Aug)
17.^Lombardi B, Pani P, Schlunk FFCholine-deficiency fatty liver: impaired release of hepatic triglyceridesJ Lipid Res.(1968 Jul)
21.^Ridgway ND, Vance DEKinetic mechanism of phosphatidylethanolamine N-methyltransferaseJ Biol Chem.(1988 Nov 15)
22.^Alfthan G, Tapani K, Nissinen K, Saarela J, Aro AThe effect of low doses of betaine on plasma homocysteine in healthy volunteersBr J Nutr.(2004 Oct)
23.^Humbert JA, Hammond KB, Hathaway WETrimethylaminuria: the fish-odour syndromeLancet.(1970 Oct 10)
24.^Treacy EP, Akerman BR, Chow LM, Youil R, Bibeau C, Lin J, Bruce AG, Knight M, Danks DM, Cashman JR, Forrest SMMutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxicationHum Mol Genet.(1998 May)
25.^Mitchell SCThe fish-odor syndromePerspect Biol Med.(1996 Summer)
26.^Fraser-Andrews EA, Manning NJ, Ashton GH, Eldridge P, McGrath J, Menagé Hdu PFish odour syndrome with features of both primary and secondary trimethylaminuriaClin Exp Dermatol.(2003 Mar)
27.^Zschocke J, Kohlmueller D, Quak E, Meissner T, Hoffmann GF, Mayatepek EMild trimethylaminuria caused by common variants in FMO3 geneLancet.(1999 Sep 4)
29.^Rehman HUFish odor syndromePostgrad Med J.(1999 Aug)