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Symptoms of Alzheimer’s

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Summary of Symptoms of Alzheimer’s

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Symptoms of Alzheimer’s


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of alzheimer’s
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Ginkgo biloba Minor Very High See all 5 studies
Cognitive impairment that is associated with Alzheimer's appears to be significantly reduced with ginkgo supplementation.
grade-c Alpha-GPC Notable - See study
At least among nutraceuticals, Alpha-GPC appears to significantly improve cognition in persons with Alzheimer's disease at the dose of 1,200mg when taken as a daily supplement over a prolonged period of time.
grade-c Vitamin E Notable Very High See 2 studies
Very high dose Vitamin E supplementation in the form of α-tocopherol (2,000 IU) appears to reduce the rate of cognitive decline in persons with moderate to severe Alzheimer's Disease with a potency comparable to selegiline. Currently no research on lower (more standard) doses, and there appears to be no influence on minor AD or cognitive decline not characterized by AD.
grade-c Saffron Minor Very High See 2 studies
Mixed evidence on the efficacy of saffron, but it is possible that supplementation could delay an increase in symptoms without a therapeutic effect.
grade-c Fish Oil  
grade-c Inositol  
grade-c Oxiracetam  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 0 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of references for this page.

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