Liver Fat Research Analysis

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver fat

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Fucoxanthin	Notable	- See study	The decrease in liver fat seen with fucoxanthin tends to be greater than that seen with other supplements, although insufficient evidence exists to suggest reliability of results
Fish Oil	Minor	- See study	A possible decreasing effect of liver fat seen in persons with NAFLD
Trimethylglycine	Minor	Very High See all 3 studies	Preliminary evidence showed a major decrease in liver fat (normalization in over half of persons with fatty liver) but currently the best evidence suggests that this does not occur as potently; there may still be a role, but this requires more research.
Vitamin E	Minor	Very High See all 3 studies	In persons with steatohepatitis, there may be a reduction in liver fat over time when taking vitamin E supplements; currently there is no evidence assessing otherwise healthy persons on this parameter
Spirulina
Whey Protein

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.