Quick Navigation

Alertness

Alertness is an aspect of wakefulness with hints of attention, and is the ability to interpret and maintain attention on different targets. Supplements that increase alertness tend to be anti-sleep or stimulatory agents.

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect alertness
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Melissa officinalis Notable Very High See 2 studies
A decrease in alertness appears to occur alongside lemon balm ingestion (with or without sedation)
grade-c Centella asiatica Minor - See study
An increase in the self-rated sensation of alertness is noted in older healthy adults supplementing with centella asiatica
grade-c Melatonin Minor - See study
A decrease in alertness has been noted with melatonin supplementation
grade-c Modafinil  
grade-c Synephrine  
grade-d Creatine  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.