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Grapefruit

Grapefruit is a food product known for having a high level of bioactives, similar to the pomegranate. It does appear to be effective at reducing fat mass when a mixture of polyphenols are used, and may work nicely with caffeine.

Our evidence-based analysis on grapefruit features 37 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Studies that use the grapefruit itself (whole fruit) tend to use one half of a grapefruit at 2-3 meals throughout the day.

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Human Effect Matrix

Unlocked for Examine Plus members

The Human Effect Matrix summarizes human studies to tell you what effects Grapefruit has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Plus members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
Fat mass appears to be reduced more in groups consuming grapefruit relative to placebo
grade-c Minor - See study
Improvement in insulin sensitivity may be secondary to weight loss
grade-c Minor - See study
A decrease in LDL cholesterol has been noted, but may be due to weight loss
grade-c Minor - See study
A decrease in total cholesterol has been noted, this is confounded with weight loss (also occurred)
grade-c Minor Very High See all 3 studies
There appears to be a weight reducing effect of grapefruit consumption relative to isocaloric controls (such as apple juice)
grade-c - - See study
No significant influence on blood flow noted
grade-d - - See study
No significant alterations in heart rate associated with grapefruit ingestion
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Frequently Asked Questions and Articles on Grapefruit

Can food have negative calories?
‘Negative calorie’ foods (foods that have fewer calories than your body expends to digest them) likely don't exist. However, food typically thought of as ‘negative calorie’ are often low in total calories and high in fiber and water content — so their regular consumption may aid in weight loss.
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Click here to see all 37 references.