Summary of Eclipta alba
Primary Information, Benefits, Effects, and Important Facts
Eclipta Alba (False Daisy) is a herb that has traditionally been used in Ayurvedic medicine for being a liver tonic (for which it is one of the more effective herbs apparently) and having beneficial effects on diabetes, eye health, and hair growth.
In regards to these claims, it appears to have some anti-diabetic effects in animal studies with the mechanism of action not yet known. Hair regrowth has been noted in repeated studies with the petroleum ether extract mostly, and its potency rivals that of Minoxidil at 2% solution; combination thrapy of Eclipta Alba with two other herbs (Citrullus Colocynthis and Cuscuta Reflexa) has outperformed Minoxidil according to one study.
Eye health does not have any direct studies on it despite its historical claims, although the one human intervention noted that 7.5% of the sample consuming 3g of the leaves daily claimed they had better eyesight; this study was blinded, and constitutes the only evidence for eye health claims. In a way it is promising (3g of the leaves themselves over 60 days improving eye health even when paricipants were unaware this could be an effect of treatment) but it does not constitute sufficient evidence in and of itself.
Beyond the possible eye/hair benefits and the liver protection, other possible benefits of Eclipta Alba are lessened anger (two animal studies, moderate oral doses), pain reduction (dose dependent, which outperfomed Aspirin when consumed at higher doses of 500mg/kg rats; 80mg/kg ethanolic extract in humans) a reduction in blood pressure, diuretic effects, with at least one study suggesting some benefit to the immune system (increasing macrophage and white blood cell activity).
A possibly promising herb for wellness and beauty, but requires more studies on it.
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Things To Know & Note
Is a Form Of
Primary Function:
Also Known As
False Daisy, Yerba de tago, Kehraj, Karisalankanni
Do Not Confuse With
Ecklonia Cava (sounds similar), Morus Alba or Basella Alba (similar species names, different herbs)
Goes Well With
Piper Longum (antioxidant effects in vitro)
Caution Notice
Examine.com Medical DisclaimerHow to Take Eclipta alba
Recommended dosage, active amounts, other details
Currently, the only human study using Eclipta Alba merely consumed 3,000mg of the leaves. This study did not use a particular extract, but crushed and encapsulated the leaves themselves.
Benefits are seen with the petroleum ether extract on hair growth (up to 5% of solution when applied topically) and the ethanolic extract for pain reduction (dose dependent up to 500mg/kg in rats, which is 80mg/kg in human equivalence).
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects eclipta alba has on your body, and how strong these effects are.
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
Level of Evidence
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The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Outcome |
Magnitude of effect
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The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
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Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
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Decreases of blood pressure in unhealthy persons using eclipta alba have occurred by 15% (mean arterial pressure)
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Urine volume has been noted to be increased by 34%, which is fairly notable as it outperforms other nutraceuticals
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Decreases in LDL-C have been noted with eclipta alba in hypertensive persons to 24%, which is quite a significant reduction.
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A decrease in biomarkers of lipid peroxidation has been noted, possible related to an increase in serum Vitamin E concentrations
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A decrease in total cholesterol has been noted with supplementation of eclipta alba
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Decreases in triglycerides have been noted, but not to a remarkable degree
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Decreases in fasting vLDL have been noted
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No detectable influence on HDL-C cholesterol
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Research Breakdown on Eclipta alba
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References
- ^ a b c d e f Manvar D, et al. Identification and evaluation of anti Hepatitis C virus phytochemicals from Eclipta alba. J Ethnopharmacol. (2012)
- ^ Diogo LC, et al. Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans. Basic Clin Pharmacol Toxicol. (2009)
- ^ a b c d e f g Wagner H, et al. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea. Planta Med. (1986)
- ^ a b c d Banji D, et al. Impact of the aqueous extract of Eclipta alba on maternal aggression in rats. Pak J Pharm Sci. (2010)
- ^ Pol H, et al. Fundamental approach in the management of Drava Bahula Amlapitta with Bhringaraja (Eclipta alba). Ayu. (2011)
- ^ Govindarajan M, Karuppannan P. Mosquito larvicidal and ovicidal properties of Eclipta alba (L.) Hassk (Asteraceae) against chikungunya vector, Aedes aegypti (Linn.) (Diptera: Culicidae). Asian Pac J Trop Med. (2011)
- ^ Govindarajan M, Sivakumar R. Mosquito adulticidal and repellent activities of botanical extracts against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae). Asian Pac J Trop Med. (2011)
- ^ Govindarajan M, Sivakumar R. Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). Parasitol Res. (2012)
- ^ a b c Roy RK, Thakur M, Dixit VK. Hair growth promoting activity of Eclipta alba in male albino rats. Arch Dermatol Res. (2008)
- ^ a b c d Halim AF, Balbaa SI, Khalil AT. Phenolics and other constituents from Eclipta alba. Planta Med. (1982)
- ^ Abdel-Kader MS, et al. DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1. J Nat Prod. (1998)
- ^ Abdel-Kader MS, et al. DNA damaging steroidal alkaloids from eclipta alba from the suriname rain fores. J Nat Prod. (2000)
- ^ a b c Upadhyay RK, et al. Eclalbatin, a triterpene saponin from Eclipta alba. J Asian Nat Prod Res. (2001)
- ^ a b Oleanane Glycosides from Eclipta prostrata.
- ^ a b c Lee MK, et al. Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells. Phytomedicine. (2008)
- ^ a b Kumar D, et al. Bio-assay guided isolation of alpha-glucosidase inhibitory constituents from Eclipta alba. Nat Prod Commun. (2012)
- ^ Zhang M, et al. Isolation and identification of ecliptasaponin D from Eclipta alba (L.) Hassk. Yao Xue Xue Bao. (1997)
- ^ Zhang M, Chen Y. Chemical constituents of Eclipta alba (L.) Hassk. Zhongguo Zhong Yao Za Zhi. (1996)
- ^ Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. (2003)
- ^ a b Banji O, et al. Investigation on the effect of eclipta alba on animal models of learning and memory. Indian J Physiol Pharmacol. (2007)
- ^ a b c Thakur VD, Mengi SA. Neuropharmacological profile of Eclipta alba (Linn.) Hassk. J Ethnopharmacol. (2005)
- ^ a b Mansoorali KP, et al. Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats. Phytomedicine. (2012)
- ^ Lobo OJ, et al. Evaluation of antiaggressive activity of Eclipta alba in experimental animals. Pak J Pharm Sci. (2008)
- ^ a b Sawant M, Isaac JC, Narayanan S. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. Phytother Res. (2004)
- ^ a b Leal LK, et al. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J Ethnopharmacol. (2000)
- ^ a b Pandey PS, Upadhyay KK, Pandey DN. Experimental evaluation of the analgesic property of eclipta alba (L) hassk. Anc Sci Life. (1997)
- ^ a b c d e f g h Rangineni V, Sharada D, Saxena S. Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot study. J Med Food. (2007)
- ^ a b c d Jaiswal N, et al. Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase. Nat Prod Res. (2012)
- ^ a b Ananthi J, Prakasam A, Pugalendi KV. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. Yale J Biol Med. (2003)
- ^ a b Jayathirtha MG, Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine. (2004)
- ^ Kumar SS, et al. Evaluation of Anti -Inflammatory Activity of Eclipta alba in rats. Anc Sci Life. (2005)
- ^ Singh B, et al. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol. (2001)
- ^ a b Ma-Ma K, Nyunt N, Tin KM. The protective effect of Eclipta alba on carbon tetrachloride-induced acute liver damage. Toxicol Appl Pharmacol. (1978)
- ^ Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol. (1993)
- ^ Chandra T, Sadique J. A new receipt for liver injury. Anc Sci Life. (1987)
- ^ Murthy VN, et al. Antihepatotoxic activity of eclipta alba, tephrosia purpurea and boerhaavia diffusa. Anc Sci Life. (1992)
- ^ a b c d Chaudhary H, et al. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: an in vitro study. J Ethnopharmacol. (2011)
- ^ a b Datta K, et al. Eclipta alba extract with potential for hair growth promoting activity. J Ethnopharmacol. (2009)
- ^ a b Roy RK, Thakur M, Dixit VK. Development and evaluation of polyherbal formulation for hair growth-promoting activity. J Cosmet Dermatol. (2007)
- ^ Ramesh V, et al. Antioxidant activity of combined ethanolic extract of Eclipta alba and Piper longum Linn. J Complement Integr Med. (2011)
- ^ Teschke R, Bahre R. Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessment. Ann Hepatol. (2009)