White Mulberry

Last Updated: September 28 2022

Morus Alba (White Mulberry) is a plant where both the fruit and roots have been used traditionally for vitality and immune support; it may have cognitive enhancing properties (mostly unexplored) and anti-cancer effects.

White Mulberry is most often used for


Morus Alba is the White Mulberry, although the fruits are what 'White Mulberry' refers to the stems and leaves are also commonly used as a tea and, more recently, in supplements as ethanolic/ethyl acetate extractions (supplements, or a wine extraction) appear to concentrate the bioactives. The term Morus can be seen as synonymus with the common word 'Mulberry' where the species of Alba literally means White (derived from the Latin term Albus). Other Morus herbs differ in their coloration, such as Morus Nigra (Black Mulberry) and are not the subject of this article.

White Mulberry has had all parts of it used in Traditional Chinese Medicine for a variety of purposes, but currently most evidence on Morus Alba is in regards to its anti-diabetic properties. Surprisingly, there is a large body of repeated rodent evidence to suggest it effective in reducing blood sugar regardless of previous state (toxin-induced diabetic, diet-induced diabetic, genetically diabetic or normal rodents) but with no current human evidence.

It merely appears to inhibit absorption of carbohydrates from the intestines, with most potency on inhibiting sugar absorption (fairly weak in inhibiting starch absorption, but is synergistic with Hibiscus Sabdariffa on this which would make a nice combination). For the most part, this is tied back into the iminosugar compound known as 1-deoxynojirimycin which is a glucose molecule with a nitrogen attached it it; it inhibits enzymes that have affinity for sugars via competitive inhibition where the enzyme is attracted to the glucose structure but cannot act effectively due to the nitrogen group (which does not exist on sugars normally and hinders the enzyme's functions)

There appear to be promising cognitive effects associated with Morus Alba as well, with some evidence suggesting it can increase memory formation and cognition to a level similar to Piracetam; interesting, there are some pyrrole alkaloids in Morus Alba (a structural class of molecules that Piracetam belongs to) but these have not yet been connected to the observed cognitive benefits.

Morus Alba may also have respectible benefits to cardiovascular health (with improvements in circulating lipids and cholesterol, with fairly potent reductions in atherosclerotic plaque buildup possibly related to potent in vitro anti-inflammatory properties) but similar to the other claims these have not yet been tested in humans.

Currently, the evidence suggests that Morus Alba is a highly promising functional food and tea product that may have benefit as a supplement especially in regards to cognition and glucose control but currently does not have sufficient evidence to suggest how potent these benefits are in humans and whether or not Morus Alba is a 'go-to' supplement.

What else is White Mulberry known as?
Note that White Mulberry is also known as:
  • White Mulberry
  • Karayamaguwa
  • Sohakuhi
  • Sang-Bai-Pi
  • Ramulus Mori
  • Morus Alba
White Mulberry should not be confused with:
Dosage information

For the purpose of reducing carbohydrate absorption and glucose spikes following a meal, morus alba must be consumed alongisde said carbohydrate source. The dosage appears to be 500-1,000mg/kg in rat studies (assuming about a 0.11% 1-deoxynojirimicin content) which is an estimated human dose of:

  • 5,400-11,000mg for a 150lb person
  • 7,300-14,500mg for a 200lb person
  • 9,000-18,000mg for a 250lb person

Concentrated extracts may reduce the above requirement, so a 10:1 concentrated extract (for the 1-deoxynojirimicin content) would then require 900-1,800mg at the heaviest weight.

For inflammation and other health related issues (such as uric acid), the rat dose appears to be in the range of 20-200mg/kg which is an estimated human dose of:

  • 220-2,200mg for a 150lb person
  • 300-2,900mg for a 200lb person
  • 400-3,600mg for a 250lb person

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1.^Kikuchi T, Nihei M, Nagai H, Fukushi H, Tabata K, Suzuki T, Akihisa TAlbanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell lineChem Pharm Bull (Tokyo).(2010 Apr)
2.^Nomura T, Hano Y, Fukai TChemistry and biosynthesis of isoprenylated flavonoids from Japanese mulberry treeProc Jpn Acad Ser B Phys Biol Sci.(2009)
3.^Shi YW, Wang CP, Wang X, Zhang YL, Liu L, Wang RW, Ye JF, Hu LS, Kong LDUricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic miceJ Ethnopharmacol.(2012 Oct 11)
8.^Imran M, Khan H, Shah M, Khan R, Khan FChemical composition and antioxidant activity of certain Morus speciesJ Zhejiang Univ Sci B.(2010 Dec)
10.^Chen SK, Zhao P, Shao YX, Li Z, Zhang C, Liu P, He X, Luo HB, Hu XMoracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitorBioorg Med Chem Lett.(2012 May 1)
11.^Arias L, Vara Y, Cossío FPRegioselective preparation of benzo(b)furans from phenols and α-bromoketonesJ Org Chem.(2012 Jan 6)
13.^Yang Y, Gong T, Liu C, Chen RYFour new 2-arylbenzofuran derivatives from leaves of Morus alba LChem Pharm Bull (Tokyo).(2010 Feb)
15.^Fukai T, Hano Y, Hirakura K, Nomura T, Uzawa J, Fukushima KStructures of two natural hypotensive Diels-Alder type adducts, mulberrofurans F and G, from the cultivated mulberry tree (Morus lhou KOIDZ.)Chem Pharm Bull (Tokyo).(1985 Aug)
16.^Geng C, Yao S, Xue D, Zuo A, Zhang X, Jiang Z, Ma Y, Chen JNew isoprenylated flavonoid from Morus albaZhongguo Zhong Yao Za Zhi.(2010 Jun)
17.^Geng CA, Ma YB, Zhang XM, Yao SY, Xue DQ, Zhang RP, Chen JJMulberrofuran G and isomulberrofuran G from Morus alba L.: anti-hepatitis B virus activity and mass spectrometric fragmentationJ Agric Food Chem.(2012 Aug 22)
18.^Smejkal K, Svacinová J, Slapetová T, Schneiderová K, Dall'acqua S, Innocenti G, Závalová V, Kollár P, Chudík S, Marek R, Julínek O, Urbanová M, Kartal M, Csöllei M, Dolezal KCytotoxic activities of several geranyl-substituted flavanonesJ Nat Prod.(2010 Apr 23)
19.^Phung TX, Tran TH, Dan TT, Chau VM, Hoang TH, Nguyen TDChalcone-derived Diels-Alder adducts as NF-κB inhibitors from Morus albaJ Asian Nat Prod Res.(2012)
20.^Dat NT, Binh PT, Quynh le TP, Van Minh C, Huong HT, Lee JJCytotoxic prenylated flavonoids from Morus albaFitoterapia.(2010 Dec)
22.^Rollinger JM, Bodensieck A, Seger C, Ellmerer EP, Bauer R, Langer T, Stuppner HDiscovering COX-inhibiting constituents of Morus root bark: activity-guided versus computer-aided methodsPlanta Med.(2005 May)
23.^Kim SB, Chang BY, Jo YH, Lee SH, Han SB, Hwang BY, Kim SY, Lee MKMacrophage activating activity of pyrrole alkaloids from Morus alba fruitsJ Ethnopharmacol.(2013 Jan 9)
24.^Hunyadi A, Veres K, Danko B, Kele Z, Weber E, Hetenyi A, Zupko I, Hsieh TJIn vitro Anti-diabetic Activity and Chemical Characterization of an Apolar Fraction of Morus alba Leaf Water ExtractPhytother Res.(2012 Aug 16)
25.^Ali A, Ali MNew triterpenoids from Morus alba L. stem barkNat Prod Res.(2012 Apr 5)
26.^Yang Y, Zhang T, Xiao L, Chen RYTwo novel flavanes from the leaves of Morus alba LJ Asian Nat Prod Res.(2010 Mar)
27.^Lee JJ, Yang H, Yoo YM, Hong SS, Lee D, Lee HJ, Lee HJ, Myung CS, Choi KC, Jeung EBMorusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular diseaseJ Atheroscler Thromb.(2012)
28.^Yang Y, Zhang T, Xiao L, Yang L, Chen RTwo new chalcones from leaves of Morus alba LFitoterapia.(2010 Sep)
30.^Ahmad A, Gupta G, Afzal M, Kazmi I, Anwar FAntiulcer and antioxidant activities of a new steroid from Morus albaLife Sci.(2012 Dec 24)
31.^Hošek J, Bartos M, Chudík S, Dall'Acqua S, Innocenti G, Kartal M, Kokoška L, Kollár P, Kutil Z, Landa P, Marek R, Závalová V, Žemlička M, Šmejkal KNatural compound cudraflavone B shows promising anti-inflammatory properties in vitroJ Nat Prod.(2011 Apr 25)
32.^Oh H, Ko EK, Jun JY, Oh MH, Park SU, Kang KH, Lee HS, Kim YCHepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus albaPlanta Med.(2002 Oct)
33.^Weber JT, Lamont M, Chibrikova L, Fekkes D, Vlug AS, Lorenz P, Kreutzmann P, Slemmer JEPotential neuroprotective effects of oxyresveratrol against traumatic injuryEur J Pharmacol.(2012 Apr 5)
36.^Zhang M, Chen M, Zhang HQ, Sun S, Xia B, Wu FHIn vivo hypoglycemic effects of phenolics from the root bark of Morus albaFitoterapia.(2009 Dec)
37.^Yang Y, Wang HQ, Chen RYFlavonoids from the leaves of Morus alba LYao Xue Xue Bao.(2010 Jan)
38.^Oh BK, Oh KS, Kwon KI, Ryu SY, Kim YS, Lee BHMelanin-concentrating hormone-1 receptor binding activity of pheophorbides isolated from Morus alba leavesPhytother Res.(2010 Jun)
39.^Dugo P, Donato P, Cacciola F, Germanò MP, Rapisarda A, Mondello LCharacterization of the polyphenolic fraction of Morus alba leaves extracts by HPLC coupled to a hybrid IT-TOF MS systemJ Sep Sci.(2009 Nov)
41.^Nuengchamnong N, Ingkaninan K, Kaewruang W, Wongareonwanakij S, Hongthongdaeng BQuantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometryJ Pharm Biomed Anal.(2007 Aug 15)
42.^Amézqueta S, Galán E, Fuguet E, Carrascal M, Abián J, Torres JLDetermination of D-fagomine in buckwheat and mulberry by cation exchange HPLC/ESI-Q-MSAnal Bioanal Chem.(2012 Feb)
43.^Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, Kato A, Nash RJ, Lee HS, Ryu KSPolyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.)J Agric Food Chem.(2001 Sep)
49.^Chang LW, Juang LJ, Wang BS, Wang MY, Tai HM, Hung WJ, Chen YJ, Huang MHAntioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root barkFood Chem Toxicol.(2011 Apr)
50.^Deepa M, Sureshkumar T, Satheeshkumar PK, Priya SPurified mulberry leaf lectin (MLL) induces apoptosis and cell cycle arrest in human breast cancer and colon cancer cellsChem Biol Interact.(2012 Oct 25)
52.^Duran A, Tuzen M, Soylak MTrace element levels in some dried fruit samples from TurkeyInt J Food Sci Nutr.(2008 Nov-Dec)
54.^Kim ES, Park SJ, Lee EJ, Kim BK, Huh H, Lee BJPurification and characterization of Moran 20K from Morus albaArch Pharm Res.(1999 Feb)
55.^Hikino H, Mizuno T, Oshima Y, Konno CIsolation and hypoglycemic activity of moran A, a glycoprotein of Morus alba root barksPlanta Med.(1985 Apr)
56.^Adisakwattana S, Ruengsamran T, Kampa P, Sompong WIn vitro inhibitory effects of plant-based foods and their combinations on intestinal α-glucosidase and pancreatic α-amylaseBMC Complement Altern Med.(2012 Jul 31)
58.^Arfan M, Khan R, Rybarczyk A, Amarowicz RAntioxidant activity of mulberry fruit extractsInt J Mol Sci.(2012)
63.^Zhaxi M, Chen L, Li X, Komatsu K, Yao X, Qiu FThree major metabolites of mulberroside A in rat intestinal contents and fecesPlanta Med.(2010 Mar)
66.^Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JHResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesCell.(2012 Feb 3)
67.^van Staveren WC, Markerink-van Ittersum M, Steinbusch HW, de Vente JThe effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the ratBrain Res.(2001 Jan 12)
71.^Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue HAnxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis GeorgiBiochem Pharmacol.(2002 Nov 1)
74.^Nade VS, Kawale LA, Naik RA, Yadav AVAdaptogenic effect of Morus alba on chronic footshock-induced stress in ratsIndian J Pharmacol.(2009 Dec)
78.^Yadav AV, Kawale LA, Nade VSEffect of Morus alba L. (mulberry) leaves on anxiety in miceIndian J Pharmacol.(2008 Jan)
79.^Sun X, Zhang K, Ji X, Wang Y, Jeffrey Z, Tong Y, Gao H, Zhang J, Wang ZScreening of pancreatic lipase and alpha-glucosidase inhibitors from Chinese dietary herbsZhongguo Zhong Yao Za Zhi.(2012 May)
80.^Hassan AMTLC bioautographic method for detecting lipase inhibitorsPhytochem Anal.(2012 Jul-Aug)
81.^Duangjai A, Ingkaninan K, Limpeanchob NPotential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extractsNat Prod Res.(2011 Feb)
85.^Lee YJ, Choi DH, Kim EJ, Kim HY, Kwon TO, Kang DG, Lee HSHypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic dietAm J Chin Med.(2011)
87.^Pirvulescu MM, Gan AM, Stan D, Simion V, Calin M, Butoi E, Tirgoviste CI, Manduteanu ICurcumin and a Morus alba extract reduce pro-inflammatory effects of resistin in human endothelial cellsPhytother Res.(2011 Dec)
88.^Manduteanu I, Pirvulescu M, Gan AM, Stan D, Simion V, Dragomir E, Calin M, Manea A, Simionescu MSimilar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cellsBiochem Biophys Res Commun.(2010 Jan 15)
89.^Ma X, Iwanaka N, Masuda S, Karaike K, Egawa T, Hamada T, Toyoda T, Miyamoto L, Nakao K, Hayashi TMorus alba leaf extract stimulates 5'-AMP-activated protein kinase in isolated rat skeletal muscleJ Ethnopharmacol.(2009 Feb 25)
93.^Naowaboot J, Pannangpetch P, Kukongviriyapan V, Prawan A, Kukongviriyapan U, Itharat AMulberry leaf extract stimulates glucose uptake and GLUT4 translocation in rat adipocytesAm J Chin Med.(2012)
94.^Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli OMolecular characterization of the melanin-concentrating-hormone receptorNature.(1999 Jul 15)
100.^Benalla W, Bellahcen S, Bnouham MAntidiabetic medicinal plants as a source of alpha glucosidase inhibitorsCurr Diabetes Rev.(2010 Jul)
102.^P S, Zinjarde SS, Bhargava SY, Kumar ARPotent α-amylase inhibitory activity of Indian Ayurvedic medicinal plantsBMC Complement Altern Med.(2011 Jan 20)
104.^Oku T, Tanabe K, Ogawa S, Sadamori N, Nakamura SSimilarity of hydrolyzing activity of human and rat small intestinal disaccharidasesClin Exp Gastroenterol.(2011)
106.^Gómez L, Molinar-Toribio E, Calvo-Torras MÁ, Adelantado C, Juan ME, Planas JM, Cañas X, Lozano C, Pumarola S, Clapés P, Torres JLD-Fagomine lowers postprandial blood glucose and modulates bacterial adhesionBr J Nutr.(2012 Jun)
108.^Katsube T, Yamasaki M, Shiwaku K, Ishijima T, Matsumoto I, Abe K, Yamasaki YEffect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese miceJ Sci Food Agric.(2010 Nov)
110.^Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan UAntihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic ratsPlant Foods Hum Nutr.(2009 Jun)
113.^Miyahara C, Miyazawa M, Satoh S, Sakai A, Mizusaki SInhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal ratsJ Nutr Sci Vitaminol (Tokyo).(2004 Jun)
114.^Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M; STOP-NIDDM Trail Research GroupAcarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trialLancet.(2002 Jun 15)
116.^Dat NT, Binh PT, Quynh le TP, Huong HT, Minh CVSanggenon C and O inhibit NO production, iNOS expression and NF-κB activation in LPS-induced RAW264.7 cellsImmunopharmacol Immunotoxicol.(2012 Feb)
119.^Rodríguez-Manzaneque JC, Westling J, Thai SN, Luque A, Knauper V, Murphy G, Sandy JD, Iruela-Arispe MLADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitorsBiochem Biophys Res Commun.(2002 Apr 26)
120.^Kuno K, Okada Y, Kawashima H, Nakamura H, Miyasaka M, Ohno H, Matsushima KADAMTS-1 cleaves a cartilage proteoglycan, aggrecanFEBS Lett.(2000 Aug 4)
121.^O'Byrne PM, Inman MDAirway hyperresponsivenessChest.(2003 Mar)
123.^Wang CP, Wang Y, Wang X, Zhang X, Ye JF, Hu LS, Kong LDMulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic micePlanta Med.(2011 May)
125.^Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN, Knott SA, Kolcic I, Polasek O, Graessler J, Wilson JF, Marinaki A, Riches PL, Shu X, Janicijevic B, Smolej-Narancic N, Gorgoni B, Morgan J, Campbell S, Biloglav Z, Barac-Lauc L, Pericic M, Klaric IM, Zgaga L, Skaric-Juric T, Wild SH, Richardson WA, Hohenstein P, Kimber CH, Tenesa A, Donnelly LA, Fairbanks LD, Aringer M, McKeigue PM, Ralston SH, Morris AD, Rudan P, Hastie ND, Campbell H, Wright AFSLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and goutNat Genet.(2008 Apr)
127.^Badreshia-Bansal S, Draelos ZDInsight into skin lightening cosmeceuticals for women of colorJ Drugs Dermatol.(2007 Jan)
129.^Kim JK, Kim M, Cho SG, Kim MK, Kim SW, Lim YHBiotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibitionJ Ind Microbiol Biotechnol.(2010 Jun)
130.^Zheng ZP, Cheng KW, Zhu Q, Wang XC, Lin ZX, Wang MTyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship studyJ Agric Food Chem.(2010 May 12)
133.^Wang HJ, Chiang BHAnti-diabetic effect of a traditional Chinese medicine formulaFood Funct.(2012 Nov)
135.^Kim HG, Ju MS, Park H, Seo Y, Jang YP, Hong J, Oh MSEvaluation of Samjunghwan, a traditional medicine, for neuroprotection against damage by amyloid-beta in rat cortical neuronsJ Ethnopharmacol.(2010 Aug 9)
136.^El-Sayyad HI, El-Sherbiny MA, Sobh MA, Abou-El-Naga AM, Ibrahim MA, Mousa SAProtective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother ratsInt J Biol Sci.(2011)
137.^Hemmer W, Focke M, Marzban G, Swoboda I, Jarisch R, Laimer MIdentification of Bet v 1-related allergens in fig and other Moraceae fruitsClin Exp Allergy.(2010 Apr)