Proteinuria Research Analysis

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect proteinuria

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Ginkgo biloba	Notable	- See study	The study in diabetics noting a reduction in urinary albumin noted a near halving over 8 weeks with a low dose of ginkgo.
Curcumin	Minor	- See study	A reduction in proteinuria has been noted in persons with kidney impairment given curcumin
Benfotiamine	-	Very High See 2 studies	No evidence to support a reduction in the amount of protein lost in the urine of persons with diabetic nephropathy (UAE between 15-300mg/24 hours). Whether there is a preventative effect or not, there does not appear to be a rehabilitative effect.
Chromium	-	- See study	Chromium supplementation does not appear to cause proteinuria (protein losses in the urine) suggesting no kidney toxicity, as proteinuria is a biomarker of such damage.
Creatine
Fish Oil
Nigella sativa
Chlorella
Ganoderma lucidum

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.