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Proteinuria

Proteinuria is losses of large protein structures in the urine, which normally does not occur and signifies structural damage to the kidneys. A higher rate of proteinuria correlates with worsened kidney damage, and reductions in proteinuria reflect improved renal function.

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect proteinuria
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Ginkgo biloba Notable - See study
The study in diabetics noting a reduction in urinary albumin noted a near halving over 8 weeks with a low dose of ginkgo.
grade-c Curcumin Minor - See study
A reduction in proteinuria has been noted in persons with kidney impairment given curcumin
grade-c Benfotiamine - Very High See 2 studies
No evidence to support a reduction in the amount of protein lost in the urine of persons with diabetic nephropathy (UAE between 15-300mg/24 hours). Whether there is a preventative effect or not, there does not appear to be a rehabilitative effect.
grade-c Chromium - - See study
Chromium supplementation does not appear to cause proteinuria (protein losses in the urine) suggesting no kidney toxicity, as proteinuria is a biomarker of such damage.
grade-c Creatine  
grade-c Fish Oil  
grade-c Nigella sativa  
grade-d Chlorella  
grade-d Ganoderma lucidum  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.