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Fertility

Fertility refers to the capacity to create children, and in regards to supplementation this tends to refer to seminal parameters such as semen quality or semen motility.

Our evidence-based analysis on fertility features 7 unique references to scientific papers.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Frequently Asked Questions about Fertility

Ashwagandha benefits for men
Ashwagandha does appear to have benefits for men specifically. These tend to centralize around testicular health and fertility while the antistress effects affect both sexes.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect fertility
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Inositol Notable Very High See all 9 studies
In women with PCOS, inositol (typically 2000 mg once or twice daily) can significantly increase ovulation and fertility rates.
grade-c Dehydroepiandrosterone Minor Very High See 2 studies
An increase in fertility has been noted with DHEA supplementation
grade-c Zinc Minor Moderate See 2 studies
Zinc can increase the fertility of men who are infertile and have low circulating testosterone, and appears ineffective in men who have normal testosterone levels with infertility. This is related to an increase in sperm count seen in the former group.
grade-c Astaxanthin  
grade-d D-Aspartic Acid  
grade-d Coenzyme Q10  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

References

  1. Mahdi AA, et al. Withania somnifera Improves Semen Quality in Stress-Related Male Fertility. Evid Based Complement Alternat Med. (2009)
  2. Gupta A, et al. Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. J Ethnopharmacol. (2013)
  3. Mayor S. Testosterone may improve sexual function and mood in older men with low levels. BMJ. (2016)
  4. Andrade C, et al. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian J Psychiatry. (2000)
  5. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. (2012)
  6. Agnihotri AP, et al. Effects of Withania somnifera in patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. (2013)
  7. Raut AA, et al. Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. J Ayurveda Integr Med. (2012)