Hyaluronic Acid

Last Updated: November 18 2022

Hyaluronic acid is a large polysaccharide found in many tissues, especially cartilage and synovial fluid. It is often supplemented for skin and join health, as well as for dry eyes when used as an ingredient in eye drops.

Hyaluronic Acid is most often used for

What else is Hyaluronic Acid known as?
Note that Hyaluronic Acid is also known as:
  • Hyaluronan
  • Hyaluronate (as sodium or potassium salt)
Dosage information

Dry eyes: If hyaluronic acid is the only active ingredient, 0.3% solution may be best. If other active ingredients are present, a minimum of 0.1% has been shown to be effective.

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1.^Lyndon Jones, Laura E Downie, Donald Korb, Jose M Benitez-Del-Castillo, Reza Dana, Sophie X Deng, Pham N Dong, Gerd Geerling, Richard Yudi Hida, Yang Liu, Kyoung Yul Seo, Joseph Tauber, Tais H Wakamatsu, Jianjiang Xu, James S Wolffsohn, Jennifer P CraigTFOS DEWS II Management and Therapy ReportOcul Surf.(2017 Jul)
2.^Yun-Jung Yang, Won-Young Lee, Young-Jin Kim, Yeon-Pyo HongA Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye SyndromeInt J Environ Res Public Health.(2021 Mar 1)
3.^Weiping Wu, Lifen Chen, Yanzhong Wang, Jing Jin, Xinyou Xie, Jun ZhangHyaluronic acid predicts poor prognosis in breast cancer patients: A protocol for systematic review and meta analysisMedicine (Baltimore).(2020 May 29)
4.^Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu, Hongbing JiangHyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasionJ Exp Clin Cancer Res.(2016 Nov 25)
5.^Andreas Josefsson, Hani Adamo, Peter Hammarsten, Torvald Granfors, Pär Stattin, Lars Egevad, Anna Engström Laurent, Pernilla Wikström, Anders BerghProstate cancer increases hyaluronan in surrounding nonmalignant stroma, and this response is associated with tumor growth and an unfavorable outcomeAm J Pathol.(2011 Oct)
6.^Man Wu, Manlin Cao, Yiqing He, Yiwen Liu, Cuixia Yang, Yan Du, Wenjuan Wang, Feng GaoA novel role of low molecular weight hyaluronan in breast cancer metastasisFASEB J.(2015 Apr)
7.^Essi L J Hiltunen, Maarit Anttila, Anne Kultti, Kirsi Ropponen, Jorma Penttinen, Merja Yliskoski, Arja T Kuronen, Matti Juhola, Raija Tammi, Markku Tammi, Veli-Matti KosmaElevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumorsCancer Res.(2002 Nov 15)
8.^Zoe K Price, Noor A Lokman, Carmela RicciardelliDiffering Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy ResistanceCancers (Basel).(2018 Dec 3)
9.^Xiao Tian, Jorge Azpurua, Christopher Hine, Amita Vaidya, Max Myakishev-Rempel, Julia Ablaeva, Zhiyong Mao, Eviatar Nevo, Vera Gorbunova, Andrei SeluanovHigh-molecular-mass hyaluronan mediates the cancer resistance of the naked mole ratNature.(2013 Jul 18)
10.^Peter K Kim, Christopher J Halbrook, Samuel A Kerk, Megan Radyk, Stephanie Wisner, Daniel M Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D Welling, Li Zhang, Matthew R Pratt, Kayvan R Keshari, Haoqiang Ying, Costas A LyssiotisHyaluronic acid fuels pancreatic cancer cell growthElife.(2021 Dec 24)
11.^Satoshi Seino, Fumitaka Takeshita, Akira Asari, Yasunobu Masuda, Masaaki Kunou, Takahiro OchiyaNo influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary formationJ Food Sci.(2014 Jul)