DHT

Dihydrotestosterone (DHT) is a derivative of testosterone that is known as being more potent at signalling through the androgen receptor, and due to this it is involved to a larger degree in hair loss and prostate cancer.

This page features 10 unique references to scientific papers.


Research analysis by and verified by the Examine.com Research Team. Last updated on Apr 29, 2017.

Frequently Asked Questions

Questions and answers regarding DHT

Q: Does creatine cause baldness?

A: It is plausible. Creatine increases DHT and DHT is implicated in the pathology and a receding hair line. No direct studies have been conducted assessing the connection

Read full answer to "Does creatine cause baldness?"


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect dht

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
Creatine
All comparative evidence is now gathered in our ​Supplement Goals Reference.
The evidence for each separate supplement is still freely available ​here.
Dehydroepiandrosterone  
Fenugreek  
Zinc  
Saw Palmetto  
Boron  

Scientific Support & Reference Citations

Via HEM and FAQ:

  1. Rathnayake D, Sinclair R. Male androgenetic alopecia. Expert Opin Pharmacother. (2010)
  2. Wright AS, et al. Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat. J Clin Invest. (1996)
  3. Bartsch G, Rittmaster RS, Klocker H. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol. (2002)
  4. Ryu HK, et al. Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration. Br J Dermatol. (2006)
  5. Dallob AL, et al. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. J Clin Endocrinol Metab. (1994)
  6. Bang HJ, et al. Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness. J Dermatol Sci. (2004)
  7. van der Merwe J, Brooks NE, Myburgh KH. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Clin J Sport Med. (2009)
  8. Green G. Creatine supplementation and DHT:T ratio in male rugby players. Clin J Sport Med. (2010)
  9. Volek JS, et al. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol. (2004)
  10. Op 't Eijnde B, Hespel P. Short-term creatine supplementation does not alter the hormonal response to resistance training. Med Sci Sports Exerc. (2001)