Last Updated: September 28 2022

Phosphatidylserine (PS) is an amino acid derivative compound that is fat-soluble and found in high amounts in the brain, where it contributes to cognitive functioning. Found in high amounts in fish, it may improve memory in the elderly and lowers cortisol.

Phosphatidylserine is most often used for


Phosphatidylserine, or PS, is a compound similar to a dietary fat which is highly prevalent in human neural tissue. It can be synthesized as well as consumed through the diet , but further benefits can be gained through supplementation.

It is vital for cognitive function, but is not necessarily needed as the body synthesizes it. However, Phosphatidylserine (PS) supplementation in older individuals seems to improve memory and cognitive capacity.

What else is Phosphatidylserine known as?
Note that Phosphatidylserine is also known as:
  • PS
Phosphatidylserine should not be confused with:
  • Serine
Dosage information

A standard dose of phosphatidylserine (PS) is 100mg, taken 3 times a day to total 300mg daily. This dose seems to be effective as a daily preventative against cognitive decline, and 100mg once daily may provide some degree of benefit (but may be lesser than 300mg).

Studies in children and adolescents for the purpose of attention improvement tend to use 200mg, and a dose of 200-400mg has been used in adult non-elderly humans with success. Animal evidence tends to use a dose correlating to 550mg as well.

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