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Skin Pigmentation

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team.
Published:
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Summary of Skin Pigmentation

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Skin Pigmentation


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect skin pigmentation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Vitamin A - - See all 3 studies
grade-c Vitamin B3 (Niacin) Minor - See study
In subjects with hyperpigmented spots, topical application of nicotinamide cream (5%) was able to reduce the miscoloration more than control.

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.