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Ammonia

Ammonia is a metabolic byproduct of amino acids, with increases in serum ammonia being associated with some disease states (hepatic encephalopathy) or prolonged exercise; its reduction may improve endurance.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Ammonia.

Full details on all Ammonia supplements are available to Examine Members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 11 studies
A decrease in ammonia has been noted, and appears to influence both hepatic encephalopathy as well as persons with no significant liver damage.
grade-b
Minor
Low See all 3 studies
Differential effects on ammonia, with decreases being present when glutamine is taken as part of a daily supplement routine and measured during prolonged exercise with a possible increase with high acute doses (which fades with time)
grade-c
Minor
- See study
Human studies suggest time-dependent influences on ammonia (increase after exercise up until 2 hours, a reduction the next day) while animal studies suggest that overdosing BCAAs can reverse a reduction into an increase
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