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Ammonia

Ammonia is a metabolic byproduct of amino acids, with increases in serum ammonia being associated with some disease states (hepatic encephalopathy) or prolonged exercise; its reduction may improve endurance.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Ammonia.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 11 studies
A decrease in ammonia has been noted, and appears to influence both hepatic encephalopathy as well as persons with no significant liver damage.
grade-b
Minor
Low See all 3 studies
Differential effects on ammonia, with decreases being present when glutamine is taken as part of a daily supplement routine and measured during prolonged exercise with a possible increase with high acute doses (which fades with time)
grade-c
Minor
- See study
Human studies suggest time-dependent influences on ammonia (increase after exercise up until 2 hours, a reduction the next day) while animal studies suggest that overdosing BCAAs can reverse a reduction into an increase

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