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Testosterone Boosting

Testosterone boosters are purported to increase levels through increasing direct production or reducing conversion to estradiol. Most supplements do not have a meaningful effect in humans, if an effect at all. Free, loosely-bound, and dihydrotestosterone are the best reflection of the effects of testosterone in the body.

Our evidence-based analysis on testosterone boosting features 1 unique references to scientific papers.

Kamal
Research analysis lead by Kamal Patel
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Testosterone Boosting Summary

You may know your total testosterone levels, but they don’t tell the whole story. Your total testosterone can be divided into three categories:

  • Tightly-bound testosterone. About two-thirds of the testosterone in your blood is bound to sex hormone binding globulin (SHBG). Your body can’t use it.

  • Loosely-bound testosterone. About a third of the testosterone in your blood is bound to albumin. Your body can use it, with some effort.

  • Free testosterone. A small percentage of the testosterone in your blood (1–4%, as a rule) just floats around freely. Your body can readily use it, and the enzyme 5-alpha-reductase can convert it to dihydrotestosterone (DHT) — a very potent androgen.

Together, your loosely-bound and your free testosterone compose your bioavailable testosterone, which has a greater impact on your health than your total testosterone.

Testosterone boosters are supplements that increase your production of testosterone. Often included in this category are also supplements that only increase your percentage of free testosterone or your DHT.

1Aromatase inhibitors

Supplements that inhibit CYP19A1, the aromatase enzyme, are indirect testosterone boosters in men. CYP19A1 serves many purposes, one of which is to convert testosterone to estradiol, the predominant form of estrogen. Inhibiting this enzyme reduces the percentage of testosterone that gets converted to estradiol.

Contrary to what you might think, the male body needs estradiol,[1] though in lesser quantity than women do. When it detects that its estradiol levels are too low, it reacts by increasing its production of the base material it needs to make estradiol — in other words, it increases its production of testosterone.

Aromatase inhibitors can boost testosterone on their own, but they can also complement other testosterone boosters. If you take a supplement that increases testosterone without inhibiting the aromatase enzyme (through hypothalamic stimulation, for instance), you may find yourself with more estradiol than you need, a situation that taking an aromatase inhibitor may remedy.

If you’re a man, that is. As we saw, aromatase inhibitors hinder the conversion of androgens to estrogens; in premenopausal women, however, ovaries produce most of the estrogen, so aromatase inhibitors are much less effective.

For a list of supplements to take to boost testosterone, see our increasing testosterone page.

Things To Know & Note

Do Not Confuse With

'Steroids' (the vague societal term for illicit drugs)

References

  1. ^ Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl. (2016)




Want more in-depth information on boosting your testosterone?


Check out our increasing testosterone stack page, where we feature information and infographics on what testosterone is, what impacts it, and how you can increase it.