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Stephania tetrandra

Stephania tetrandra (Fang Ji) is a medicinal herb from Traditional Chinese Medicine that is sometimes used alongside Astragalus membranaceus for kidney protection and diabetes prevention; it is moderately antiinflammatory.

Our evidence-based analysis on stephania tetrandra features 75 unique references to scientific papers.

Research analysis led by .
Reviewed by
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Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects stephania tetrandra has on your body, and how strong these effects are.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-d Minor - See study
A minor decrease in levels of lipid peroxidation in serum were noted, to the tune of 17%.
grade-d Minor - See study
A decrease in serum neutrophil elastase has been noted, and this is thought to be related to symptoms of rheumatoid arthritis
grade-d - - See study
Lymphocytes (both B and T cells) are unchanged in their overall quantity with 12 weeks of supplementation.
grade-d - - See study
No significant alterations in white blood cell count are noted with oral supplementation of this plant.

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Things to Note

Also Known As

hangfangji, Fangchi, Hang Fang Chi

Do Not Confuse With

Sinomenium acutum, Cocculus trilobus, and Aristolochia fangchi (also referred to as Fangchi)

Goes Well With

Caution Notice

Known to interact with drug metabolizing enzymes

  • Tetrandrine (a main bioactive) can inhibit CYP3A4 with moderate potency

  • Tetrandrine is able to inhibit P-glycoprotein, which underlies its synergism with berberine but may cause undesirable increases in some pharmaceuticals

  • The herb Aristolochia fangchi is also known as Fang Chi, but is a kidney toxin; if buying stephania ternatea it should be ensured that the former plant is not in the supplement by mistake

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Click here to see all 75 references.