Quick Navigation

Stephania tetrandra

Stephania tetrandra (Fang Ji) is a medicinal herb from Traditional Chinese Medicine that is sometimes used alongside Astragalus membranaceus for kidney protection and diabetes prevention; it is moderately antiinflammatory.

Our evidence-based analysis on stephania tetrandra features 75 unique references to scientific papers.

Kamal Patel
Research analysis led by and reviewed by the Examine team.
Last Updated:

Easily stay on top of the latest nutrition research

Become an Examine Member to get access to the latest research. Get 150+ studies summarized for you across 25 different categories every month.

Members also have access to the Examine Study Database of 400+ supplements and their effects on 600+ health outcomes, as well as in-depth research analyses. Understand the whole body of nutrition and supplement evidence at a glance.

Get instant access — start your free 14-day trial

Already a Member? Click here to log in.


Human Effect Matrix

Unlocked for Examine Members

Easily stay on top of the latest nutrition research

Become an Examine Member to get access to the latest research. Get 150+ studies summarized for you across 25 different categories every month.

Members also have access to the Examine Study Database of 400+ supplements and their effects on 600+ health outcomes, as well as in-depth research analyses. Understand the whole body of nutrition and supplement evidence at a glance.

Get instant access — start your free 14-day trial

Already a Member? Click here to log in.


The Human Effect Matrix summarizes human studies to tell you what effects Stephania tetrandra has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine Members. Not a Member? Try Examine Membership completely free for two weeks.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d
Lipid Peroxidation
Minor - See study
A minor decrease in levels of lipid peroxidation in serum were noted, to the tune of 17%.
grade-d
Serum Elastase
Minor - See study
A decrease in serum neutrophil elastase has been noted, and this is thought to be related to symptoms of rheumatoid arthritis
grade-d
Lymphocyte Count
- - See study
Lymphocytes (both B and T cells) are unchanged in their overall quantity with 12 weeks of supplementation.
grade-d
White Blood Cell Count
- - See study
No significant alterations in white blood cell count are noted with oral supplementation of this plant.

Stay on top of the latest research

To unlock the full archives of our Study Database and research analyses, become an Examine Member today.

Start your 14-day free trial

Things to Note

Is a Form Of

Primary Function:

Also Known As

hangfangji, Fangchi, Hang Fang Chi

Do Not Confuse With

Sinomenium acutum, Cocculus trilobus, and Aristolochia fangchi (also referred to as Fangchi)

Goes Well With

Caution Notice

Known to interact with drug metabolizing enzymes

  • Tetrandrine (a main bioactive) can inhibit CYP3A4 with moderate potency

  • Tetrandrine is able to inhibit P-glycoprotein, which underlies its synergism with berberine but may cause undesirable increases in some pharmaceuticals

  • The herb Aristolochia fangchi is also known as Fang Chi, but is a kidney toxin; if buying stephania ternatea it should be ensured that the former plant is not in the supplement by mistake

Get our free 5-day course on the essentials of supplementation.

At Examine, our incentives line up with yours — getting unbiased information. That's why we don’t sell any advertising or supplements.

Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy.

Click here to see all 75 references.

  • Get the latest research

    Examine is your partner to better health.

    Get access to the most up-to-date, in-depth research reviews. No industry ties, no sponsors, no bias.

    Try free for 14 days

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

This page features 75 references. All factual claims are followed by specifically-applicable references. Click here to see the full set of research information and references for Stephania tetrandra.

Examine.com is intended to be used for educational and information purposes only. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com.

Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com.

Supplements

Articles

Health Topics

Membership Free Trial

Protein Intake Guide + Calculator

How to read a study

Company

Resources

Never miss an update!

Your email is safe with us. We don’t share personal data.

This website is certified by Health On the Net Foundation. Click to verify.