Fang Ji

Last Updated: September 28 2022

Stephania tetrandra (Fang Ji) is a medicinal herb from Traditional Chinese Medicine that is sometimes used alongside Astragalus membranaceus for kidney protection and diabetes prevention; it is moderately antiinflammatory.

Fang Ji is most often used for

What else is Fang Ji known as?
Note that Fang Ji is also known as:
  • Hangfangji
  • Fangchi
  • Hang Fang Chi
  • Stephania Tetranda
Fang Ji should not be confused with:
  • Sinomenium acutum
  • Cocculus trilobus
  • and Aristolochia fangchi (also referred to as Fangchi)
Examine Database: Fang Ji
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2.^Ho LJ, Chang DM, Lee TC, Chang ML, Lai JHPlant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cellsEur J Pharmacol.(1999 Feb 19)
13.^Si D, Zhong D, Sha Y, Li WBiflavonoids from the aerial part of Stephania tetrandraPhytochemistry.(2001 Oct)
16.^Fu L, Liang Y, Deng L, Ding Y, Chen L, Ye Y, Yang X, Pan QCharacterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistanceCancer Chemother Pharmacol.(2004 Apr)
17.^Shan YQ, Zhu YP, Pang J, Wang YX, Song DQ, Kong WJ, Jiang JDTetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein functionBiol Pharm Bull.(2013 Aug 8)
23.^Takemura H, Imoto K, Ohshika H, Kwan CYTetrandrine as a calcium antagonistClin Exp Pharmacol Physiol.(1996 Aug)
24.^Felix JP, King VF, Shevell JL, Garcia ML, Kaczorowski GJ, Bick IR, Slaughter RSBis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding siteBiochemistry.(1992 Dec 1)
26.^Catret M, Anselmi E, Ivorra MD, Elorriaga M, Tur R, D'Ocón MPAlpha-adrenoceptor interaction of tetrandrine and isotetrandrine in the rat: functional and binding assaysJ Pharm Pharmacol.(1998 Nov)
27.^Sun X, Chan LN, Gong X, Sucher NJN-methyl-D-aspartate receptor antagonist activity in traditional Chinese stroke medicinesNeurosignals.(2003 Jan-Feb)
28.^Xue Y, Wang Y, Feng DC, Xiao BG, Xu LYTetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-kappaB pathwayActa Pharmacol Sin.(2008 Feb)
29.^Duan SR, Wang JX, Wang J, Xu R, Zhao JK, Wang DSIschemia induces endoplasmic reticulum stress and cell apoptosis in human brainNeurosci Lett.(2010 May 21)
32.^Yu XC, Wu S, Chen CF, Pang KT, Wong TMAntihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the ratJ Pharm Pharmacol.(2004 Jan)
34.^Chen L, Li QY, Yang Y, Li ZW, Zeng XRInhibitory effects of tetrandrine on the Na(+) channel of human atrial fibrillation myocardiumActa Pharmacol Sin.(2009 Feb)
36.^Lieberman I, Lentz DP, Trucco GA, Seow WK, Thong YHPrevention by tetrandrine of spontaneous development of diabetes mellitus in BB ratsDiabetes.(1992 May)
37.^Wakugami T, Islam MR, Higa S, Murakami K, Mimura GEffect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporinTohoku J Exp Med.(1993 Jan)
38.^Lieberman I, Heil BV, Seow WK, Thong YHSynergy between tetrandrine and FK506 in prevention of diabetes in BB ratsLife Sci.(1993)
41.^Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EFc-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingScience.(1994 Oct 21)
43.^Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EFNuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosJ Biol Chem.(2004 Jun 18)
51.^Siedle B, Cisielski S, Murillo R, Löser B, Castro V, Klaas CA, Hucke O, Labahn A, Melzig MF, Merfort ISesquiterpene lactones as inhibitors of human neutrophil elastaseBioorg Med Chem.(2002 Sep)
52.^Sekiya N, Shimada Y, Niizawa A, Kogure T, Mantani N, Sakai S, Hikiami H, Terasawa KSuppressive effects of Stephania tetrandra on the neutrophil function in patients with rheumatoid arthritisPhytother Res.(2004 Mar)
54.^Checkley MA, Luttge BG, Freed EOHIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporationJ Mol Biol.(2011 Jul 22)
55.^Moulard M, Decroly EMaturation of HIV envelope glycoprotein precursors by cellular endoproteasesBiochim Biophys Acta.(2000 Nov 10)
56.^Lee YS, Han SH, Lee SH, Kim YG, Park CB, Kang OH, Keum JH, Kim SB, Mun SH, Seo YS, Myung NY, Kwon DYThe mechanism of antibacterial activity of tetrandrine against Staphylococcus aureusFoodborne Pathog Dis.(2012 Aug)
57.^Lee YS, Han SH, Lee SH, Kim YG, Park CB, Kang OH, Keum JH, Kim SB, Mun SH, Shin DW, Kwon DYSynergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA)J Toxicol Sci.(2011 Oct)
58.^Zhang H, Wang K, Zhang G, Ho HI, Gao ASynergistic anti-candidal activity of tetrandrine on ketoconazole: an experimental studyPlanta Med.(2010 Jan)
60.^Wu CJ, Wang YH, Lin CJ, Chen HH, Chen YJTetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cellsToxicol In Vitro.(2011 Dec)
61.^Masaki T, Stambe C, Hill PA, Dowling J, Atkins RC, Nikolic-Paterson DJActivation of the extracellular-signal regulated protein kinase pathway in human glomerulopathiesJ Am Soc Nephrol.(2004 Jul)
62.^Hsu YC, Chiu YT, Lee CY, Wu CF, Huang YTAnti-fibrotic effects of tetrandrine on bile-duct ligated ratsCan J Physiol Pharmacol.(2006 Oct)
63.^Chor JS, Yu J, Chan KK, Go YY, Sung JJStephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in ratsJ Gastroenterol Hepatol.(2009 May)
64.^Chen J, Liu J, Wang T, Xiao H, Yin CEffects of tetrandrine on cAMP and cGMP levels in rabbit corpus cavernosum in vitroNat Prod Res.(2010 Jul)
65.^Liu JH, Chen J, Wang T, Liu B, Yang J, Chen XW, Wang SG, Yin CP, Ye ZQEffects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbitsAsian J Androl.(2006 Jul)
66.^Liu J, Chen JIon channels and penile erectionZhonghua Nan Ke Xue.(2004 Jun)
67.^Chen J, Liu JH, Wang T, Wang SG, Yin CP, Xiao HJ, Liu B, Yang J, Chen XW, Ye ZQThe relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitroZhonghua Nan Ke Xue.(2005 Oct)
68.^Chen J, Liu JH, Xiao HJ, Wang T, Chen Z, Sun CLThe relaxation effects of tetrandrine on the corpus cavernosum tissue of rabbit in vitroZhonghua Nan Ke Xue.(2003 Jun)
69.^Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JBBerberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesDiabetes.(2006 Aug)
70.^Shan YQ, Ren G, Wang YX, Pang J, Zhao ZY, Yao J, You XF, Si SY, Song DQ, Kong WJ, Jiang JDBerberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein effluxMetabolism.(2013 Mar)
71.^Maeng HJ, Yoo HJ, Kim IW, Song IS, Chung SJ, Shim CKP-glycoprotein-mediated transport of berberine across Caco-2 cell monolayersJ Pharm Sci.(2002 Dec)