Fang Ji
•Last Updated: September 28 2022
Stephania tetrandra (Fang Ji) is a medicinal herb from Traditional Chinese Medicine that is sometimes used alongside Astragalus membranaceus for kidney protection and diabetes prevention; it is moderately antiinflammatory.
Fang Ji is most often used for
Last Updated: September 28 2022
Note that Fang Ji is also known as:
- Hangfangji
- Fangchi
- Hang Fang Chi
- Stephania Tetranda
Fang Ji should not be confused with:
- Sinomenium acutum
- Cocculus trilobus
- and Aristolochia fangchi (also referred to as Fangchi)
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1.^Ruan L, Huang HS, Jin WX, Chen HM, Li XJ, Gong QJTetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGENeurochem Res.(2013 Sep)
2.^Ho LJ, Chang DM, Lee TC, Chang ML, Lai JHPlant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cellsEur J Pharmacol.(1999 Feb 19)
4.^Sim HJ, Kim JH, Lee KR, Hong JSimultaneous determination of structurally diverse compounds in different Fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MSMolecules.(2013 May 7)
5.^Joshi VC, Avula B, Khan IAAuthentication of Stephania tetrandra S. Moore (Fang Ji) and differentiation of its common adulterants using microscopy and HPLC analysisJ Nat Med.(2008 Jan)
6.^DETERMINATION OF TETRANDRINE, FANGCHINOLINE, CYCLANOLINE AND OBLONGINE IN RADIX STEPHANIAE TETRANDRAE BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.()
7.^Liu L, Li S, Chen ZSimultaneous determination of tetrandrine and fangchinoline in herbal medicine Stephania tetrandra S. Moore by liquid chromatography with electrochemical detectionJ Pharm Biomed Anal.(2012 Mar 5)
8.^Tang Y, Sun A, Liu R, Zhang YSimultaneous determination of fangchinoline and tetrandrine in Stephania tetrandra S. Moore by using 1-alkyl-3-methylimidazolium-based ionic liquids as the RP-HPLC mobile phase additivesAnal Chim Acta.(2013 Mar 12)
11.^Hong Kong samples of the traditional Chinese medicine “Fang Ji” contain aristolochic acid toxins.()
13.^Si D, Zhong D, Sha Y, Li WBiflavonoids from the aerial part of Stephania tetrandraPhytochemistry.(2001 Oct)
14.^Wong TM, Wu S, Yu XC, Li HYCardiovascular actions of Radix Stephaniae Tetrandrae: a comparison with its main component, tetrandrineActa Pharmacol Sin.(2000 Dec)
15.^Tsutsumi T, Kobayashi S, Liu YY, Kontani HAnti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra Radix in streptozotocin-diabetic miceBiol Pharm Bull.(2003 Mar)
16.^Fu L, Liang Y, Deng L, Ding Y, Chen L, Ye Y, Yang X, Pan QCharacterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistanceCancer Chemother Pharmacol.(2004 Apr)
17.^Shan YQ, Zhu YP, Pang J, Wang YX, Song DQ, Kong WJ, Jiang JDTetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein functionBiol Pharm Bull.(2013 Aug 8)
18.^Fu LW, Zhang YM, Liang YJ, Yang XP, Pan QCThe multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cellsEur J Cancer.(2002 Feb)
19.^Liu ZL, Hirano T, Tanaka S, Onda K, Oka KPersistent reversal of P-glycoprotein-mediated daunorubicin resistance by tetrandrine in multidrug-resistant human T lymphoblastoid leukemia MOLT-4 cellsJ Pharm Pharmacol.(2003 Nov)
20.^Kwan CY, Chen YY, Ma MF, Daniel EE, Hui SCTetrandrine, a calcium antagonist of Chinese herbal origin, interacts with vascular muscle alpha 1-adrenoceptorLife Sci.(1996)
21.^Leung YM, Berdik M, Kwan CY, Loh TTEffects of tetrandrine and closely related bis-benzylisoquinoline derivatives on cytosolic Ca2+ in human leukaemic HL-60 cells: a structure-activity relationship studyClin Exp Pharmacol Physiol.(1996 Aug)
22.^Wang G, Lemos JRTetrandrine: a new ligand to block voltage-dependent Ca2+ and Ca(+)-activated K+ channelsLife Sci.(1995)
23.^Takemura H, Imoto K, Ohshika H, Kwan CYTetrandrine as a calcium antagonistClin Exp Pharmacol Physiol.(1996 Aug)
24.^Felix JP, King VF, Shevell JL, Garcia ML, Kaczorowski GJ, Bick IR, Slaughter RSBis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding siteBiochemistry.(1992 Dec 1)
25.^Leung YM, Kwan CY, Loh TTDual effects of tetrandrine on cytosolic calcium in human leukaemic HL-60 cells: intracellular calcium release and calcium entry blockadeBr J Pharmacol.(1994 Nov)
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28.^Xue Y, Wang Y, Feng DC, Xiao BG, Xu LYTetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-kappaB pathwayActa Pharmacol Sin.(2008 Feb)
29.^Duan SR, Wang JX, Wang J, Xu R, Zhao JK, Wang DSIschemia induces endoplasmic reticulum stress and cell apoptosis in human brainNeurosci Lett.(2010 May 21)
30.^Paschen WEndoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesisCurr Neurovasc Res.(2004 Apr)
31.^Effects of Tetrandrine on early after depolarizations and arrhythmias induced by Cesium Chloride in rabbits.()
32.^Yu XC, Wu S, Chen CF, Pang KT, Wong TMAntihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the ratJ Pharm Pharmacol.(2004 Jan)
33.^Yu XC, Wu S, Wang GY, Shan J, Wong TM, Chen CF, Pang KTCardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heartLife Sci.(2001 May 11)
34.^Chen L, Li QY, Yang Y, Li ZW, Zeng XRInhibitory effects of tetrandrine on the Na(+) channel of human atrial fibrillation myocardiumActa Pharmacol Sin.(2009 Feb)
35.^Ma W, Nomura M, Takahashi-Nishioka T, Kobayashi SCombined effects of fangchinoline from Stephania tetrandra Radix and formononetin and calycosin from Astragalus membranaceus Radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic miceBiol Pharm Bull.(2007 Nov)
36.^Lieberman I, Lentz DP, Trucco GA, Seow WK, Thong YHPrevention by tetrandrine of spontaneous development of diabetes mellitus in BB ratsDiabetes.(1992 May)
37.^Wakugami T, Islam MR, Higa S, Murakami K, Mimura GEffect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporinTohoku J Exp Med.(1993 Jan)
38.^Lieberman I, Heil BV, Seow WK, Thong YHSynergy between tetrandrine and FK506 in prevention of diabetes in BB ratsLife Sci.(1993)
39.^Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts.()
40.^Lee SE, Woo KM, Kim SY, Kim HM, Kwack K, Lee ZH, Kim HHThe phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiationBone.(2002 Jan)
41.^Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EFc-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingScience.(1994 Oct 21)
42.^Darnay BG, Ni J, Moore PA, Aggarwal BBActivation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motifJ Biol Chem.(1999 Mar 19)
43.^Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EFNuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosJ Biol Chem.(2004 Jun 18)
44.^Takahashi T, Tonami Y, Tachibana M, Nomura M, Shimada T, Aburada M, Kobayashi STetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor κB ligand-induced osteoclast differentiationBiol Pharm Bull.(2012)
45.^Pang L, Hoult JRCytotoxicity to macrophages of tetrandrine, an antisilicosis alkaloid, accompanied by an overproduction of prostaglandinsBiochem Pharmacol.(1997 Mar 21)
46.^Shen YC, Chen CF, Wang SY, Sung YJImpediment to calcium influx and reactive oxygen production accounts for the inhibition of neutrophil Mac-1 Up-regulation and adhesion by tetrandrineMol Pharmacol.(1999 Jan)
47.^Lefer AM, Lefer DJThe role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusionCardiovasc Res.(1996 Oct)
48.^Simms HH, D'Amico RSubcellular location of neutrophil opsonic receptors is altered by exogenous reactive oxygen speciesCell Immunol.(1995 Nov)
49.^Lawson MA, Maxfield FRCa(2+)- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophilsNature.(1995 Sep 7)
51.^Siedle B, Cisielski S, Murillo R, Löser B, Castro V, Klaas CA, Hucke O, Labahn A, Melzig MF, Merfort ISesquiterpene lactones as inhibitors of human neutrophil elastaseBioorg Med Chem.(2002 Sep)
52.^Sekiya N, Shimada Y, Niizawa A, Kogure T, Mantani N, Sakai S, Hikiami H, Terasawa KSuppressive effects of Stephania tetrandra on the neutrophil function in patients with rheumatoid arthritisPhytother Res.(2004 Mar)
53.^Wan Z, Lu Y, Liao Q, Wu Y, Chen XFangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processingPLoS One.(2012)
54.^Checkley MA, Luttge BG, Freed EOHIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporationJ Mol Biol.(2011 Jul 22)
55.^Moulard M, Decroly EMaturation of HIV envelope glycoprotein precursors by cellular endoproteasesBiochim Biophys Acta.(2000 Nov 10)
56.^Lee YS, Han SH, Lee SH, Kim YG, Park CB, Kang OH, Keum JH, Kim SB, Mun SH, Seo YS, Myung NY, Kwon DYThe mechanism of antibacterial activity of tetrandrine against Staphylococcus aureusFoodborne Pathog Dis.(2012 Aug)
57.^Lee YS, Han SH, Lee SH, Kim YG, Park CB, Kang OH, Keum JH, Kim SB, Mun SH, Shin DW, Kwon DYSynergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA)J Toxicol Sci.(2011 Oct)
58.^Zhang H, Wang K, Zhang G, Ho HI, Gao ASynergistic anti-candidal activity of tetrandrine on ketoconazole: an experimental studyPlanta Med.(2010 Jan)
59.^Timoshanko JR, Kitching AR, Iwakura Y, Holdsworth SR, Tipping PGLeukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritisAm J Pathol.(2004 Jun)
60.^Wu CJ, Wang YH, Lin CJ, Chen HH, Chen YJTetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cellsToxicol In Vitro.(2011 Dec)
61.^Masaki T, Stambe C, Hill PA, Dowling J, Atkins RC, Nikolic-Paterson DJActivation of the extracellular-signal regulated protein kinase pathway in human glomerulopathiesJ Am Soc Nephrol.(2004 Jul)
62.^Hsu YC, Chiu YT, Lee CY, Wu CF, Huang YTAnti-fibrotic effects of tetrandrine on bile-duct ligated ratsCan J Physiol Pharmacol.(2006 Oct)
63.^Chor JS, Yu J, Chan KK, Go YY, Sung JJStephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in ratsJ Gastroenterol Hepatol.(2009 May)
64.^Chen J, Liu J, Wang T, Xiao H, Yin CEffects of tetrandrine on cAMP and cGMP levels in rabbit corpus cavernosum in vitroNat Prod Res.(2010 Jul)
65.^Liu JH, Chen J, Wang T, Liu B, Yang J, Chen XW, Wang SG, Yin CP, Ye ZQEffects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbitsAsian J Androl.(2006 Jul)
67.^Chen J, Liu JH, Wang T, Wang SG, Yin CP, Xiao HJ, Liu B, Yang J, Chen XW, Ye ZQThe relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitroZhonghua Nan Ke Xue.(2005 Oct)
68.^Chen J, Liu JH, Xiao HJ, Wang T, Chen Z, Sun CLThe relaxation effects of tetrandrine on the corpus cavernosum tissue of rabbit in vitroZhonghua Nan Ke Xue.(2003 Jun)
69.^Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JBBerberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesDiabetes.(2006 Aug)
70.^Shan YQ, Ren G, Wang YX, Pang J, Zhao ZY, Yao J, You XF, Si SY, Song DQ, Kong WJ, Jiang JDBerberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein effluxMetabolism.(2013 Mar)
71.^Maeng HJ, Yoo HJ, Kim IW, Song IS, Chung SJ, Shim CKP-glycoprotein-mediated transport of berberine across Caco-2 cell monolayersJ Pharm Sci.(2002 Dec)
72.^Lin HL, Liu TY, Wu CW, Chi CWBerberine modulates expression of mdr1 gene product and the responses of digestive track cancer cells to PaclitaxelBr J Cancer.(1999 Oct)
73.^Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs.()
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