A metabolite of vitamin C that may have unique effects in the body, it is currently being researched for use as a mineral chelating agent able to greatly enhance bioavailability of minerals (such as Magnesium-L-Threonate).
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This page on L-Threonate is currently marked as in-progress. We are still compiling research.
L-Threonate is a metabolite of vitamin C that is currently being investigated for some vitamin C-like properties as well as its ability to greatly enhance mineral uptake.
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L-Threonic Acid
L-Theanine
Dietary minerals as chelations
Not enough information is known at this time to suggest an optimal dose of L-Threonate in isolation.
Mineral chelations of L-Threonate should be dosed according to the active mineral content of the chelation.
L-Threonate is a deriviative of L-ascorbic acid 2-phosphate (which in and of itself is a derivative of Ascorbic Acid, otherwise known as Vitamin C).
L-threonate is able to repress the expression of a gene known as dickkopf-1 (DKK-1) which is upregualted by Dihydrotestosterone (DHT) in male pattern baldness when co-cultured.[1] It seems to work similarily to L-ascorbic acid 2-phosphate via alkaline phosphatase activity and releasing ascorbic acid into the cell.[2][3]
Independent of its use as a conjugate to Calcium as Calcium-L-Threonate (to be discussed), L-Threonate has been investigated for its usage in bone health. It has been implicated as working synergistically with calcium in the production of collagen and mineralized nodules.[4][5] and augments the uptake of ascorbic acid into fibroblasts.[6] By itself, L-theonate can also act on osteoclasts in an anti-osteoporotic manner.[7]
Minerals bound to L-theonate tend to have rapid intestinal uptake and report minimal gastrointestinal side effects. Minerals such as Iron[8][9], Calcium[5], and Magnesium[10][11] have been tested with L-Threonate chelations.[12]
The safety and toxicity of L-threonate has not been investigated.
