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Background

Polycystic ovary syndrome (PCOS) is one of the most common reproductive and endocrinological disorders among women of childbearing age. Women with PCOS often experience oligomenorrhea (infrequent menstrual periods), high levels of androgens (so-called “male hormones”), infertility, and insulin resistance. Given the importance of magnesium in carbohydrate metabolism, this study asked whether serum magnesium was associated with glycemic markers or testosterone among women with PCOS.

The study

The study was a cross-sectional analysis of a previous randomized controlled trial[1] and assessed blood samples from 1,000 women in China with PCOS to evaluate serum magnesium, fasting insulin, fasting blood glucose, the homeostatic model of insulin resistance (HOMA-IR), the quantitative insulin-sensitivity check index (QUICKI), and serum testosterone.

The results

After adjusting for confounders, women in the highest quartile of serum magnesium had lower fasting blood glucose, HOMA-IR, testosterone, and a higher QUICKI (indicative of greater insulin sensitivity) than women in the lowest quartile of serum magnesium, and they also had nonsignificantly lower insulin levels.

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This Study Summary was published on August 3, 2021.