Infantile Colic

Last Updated: August 22, 2023

“Infantile colic” is characterized by repeated episodes of intense/frequent crying or discontent with an unknown cause. Caregivers need to be reassured that they are often doing nothing wrong, and that colic usually resolves by itself within 3–4 months. However, supplementation with certain probiotics may help.

Infantile Colic falls under thePregnancy & Childrencategory.

What is infantile colic?

Infantile colic is the incessant, inconsolable, and unexplained crying or discontent of an infant within its first 5 months of life. It is very common, affecting from 10% to 40% of all infants.[1][2][3][4][5]

Excessive infant crying is the most frequent reason for pediatric consultations and hospital emergency department visits in the first few weeks of life.[1]

Fortunately, only about 5% of infants without a fever presenting to hospital with colic have a serious underlying condition.[6] In fact, due to the low risk of serious conditions plus the possibility of infants picking up an infection in the hospital,[7] it’s recommended that infants suspected of colic first be assessed in a non-hospital setting, when safely possible.[8] If there is any possibility of an emergency, the infant should, of course, be seen as soon as possible in whatever setting is immediately available.

Infantile colic is most likely to occur within the first 6 weeks of life, and to resolve by 3–4 months of age.[9][10][11][12]

Infantile colic can also affect caregivers: it is associated with caregiver exhaustion, depression, anxiety, and breastfeeding cessation, as well as with severe infant injury or death as a result of abuse.[1]

What are the main signs and symptoms of infantile colic?

Crying is the main sign of colic, but flushing of the face, clenched fists, drawing up of the legs, and flatulence can also occur.[8] These signs of colic are more likely to occur in the late afternoon and evening hours of the day.[13]

There are typically few, if any, quantifiable signs of colic, though fecal calprotectin can occasionally be higher in infants with colic.[14][15][16][17]

How is infantile colic diagnosed?

The most recent diagnostic criteria for infantile colic are from the Rome IV committee. They are: recurrent and prolonged periods of crying or fussing (i.e., not crying, but not content) without an obvious cause, and without evidence of failure to thrive or illness, in infants younger than 5 months of age.[4][1] Additionally, there is a set of criteria from 1954 that is still widely used. The Wessel criteria, or “rule of threes,” defines colic as attacks of irritability, fussing, or crying lasting 3 or more hours per day on 3 or more days per week for 3 or more weeks in an otherwise healthy baby aged 2 weeks to 4 months.[18] Abdominal distension, fever, and prolonged lethargy are seldom found in simple colic and require investigation to rule out other significant disease.[5]

What are some of the main medical treatments for infantile colic?

Practice guidelines widely differ on recommendations for colic, but they do consistently agree on:

  • clinical evaluation of the mother and baby
  • parenting information, advice, support, and reassurance
  • continuation of breastfeeding
  • probiotic supplementation in breastfed-only infants[1]

Pharmacological treatment of colic is seldom indicated.[1][19]

The utility of simethicone (which aims to prevent gas bubbles from forming in the gastrointestinal tract) for colic is inconclusive or unfavorable, with moderate to low quality evidence.[1][19][10]

Dicyclomine hydrochloride was effective for reducing crying time,[20] but is not approved for infants less than 6 months old due to side effects and is not recommended.[21] Cimetropium bromide might be effective,[22] but has possible adverse effects and is not approved for use in infants in Canada and the USA.[23][10]

Proton pump inhibitors are ineffective compared to placebo for treating colic, and may have significant adverse effects.[24][25][4][26]

Have any supplements been studied for infantile colic?

Probiotics, particularly Lactobacillus reuteri, have some of the strongest research for colic, with overall research quality ranging from low to high.[27][28][29][30][31][32][33][34][35][36] Generally, these studies gave probiotics to the mother during pregnancy and to the infant after birth.[27] No serious adverse events were reported.[27][1]

Fennel may be effective. In one study, fennel reduced total crying time by 72 minutes per day on average.[35] In another study, 65% of the participants taking 0.1% fennel seed oil resolved their colic, compared to 24% in the control group.[37] Evidence was rated as moderate quality.[19]

Sucrose was found in one study to reduce infant crying time by 101 minutes per day on average.[38] However, the evidence for this has been rated as very low quality.[19]

A trial combining fennel, chamomile, lemon balm, vitamin b1, vitamin b5, and vitamin b6 reduced crying time in infants with colic in the supplement group by 124 minutes, versus a reduction of 29 minutes in the placebo group.[39] The evidence for this was also rated as very low quality.[11]

No serious adverse events were reported for these supplements in colic.[19]

How could diet affect infantile colic?

Some clinical practice guidelines recommend maternal dietary modification for colic, but not all do. The American Academy of Family Physicians’ 2015 national guidelines for colic recommend elimination of common allergens from the maternal diet, whereas the UK and Irish national guidelines for infantile colic do not recommend modifying the maternal diet.[1][40] A recent Cochrane review examined the evidence for dietary modifications for infantile colic. Due to the effects being small, and the evidence being rated as very low quality (because of small sizes of studies, and the high risks of bias), no specific interventions were recommended.[11] However, some of the trials in this review are worth examining. Infants using a hypoallergenic (hydrolyzed) formula, compared to standard formula, had a greater reduction in crying time (on average 101 minutes per day) after 1 week. However, the number of infants who responded to the intervention was not significantly different between groups (8 of 23 infants in the hypoallergenic group versus 5 of 23 in the standard group).[41] In addition, a partially-hypoallergenic formula (lower lactose, partially hydrolyzed), compared to standard formula with simethicone, had fewer episodes of colic after 2 weeks.[42] Formula-fed infants with colic and atopic conditions (such as eczema or psoriasis) may have a higher likelihood of improving their colic with hypoallergenic formula, though much of the evidence is not based on randomized controlled trials, but instead clinical reasoning.[43][10] Soy-based formulas have insufficient quality evidence for colic to warrant recommendation.[10][44][45] Maternal diet may affect infantile colic: a group of mothers who excluded the allergens cow’s milk, eggs, peanuts, tree nuts, wheat, soy, and fish improved their breastfed babies’ colic compared to a group that did not. 74% of the low-allergen-group babies reduced their crying and fussing duration by more than 25%, compared to 37% of babies in the control group.[46]

Are there any other treatments for infantile colic?

Chiropractic medicine and osteopathy have not shown any significant effect on colic in studies at low risk of bias.[47][48][49]

In general, the higher-quality research on acupuncture indicates that it is not clinically more effective than placebo.[45] Increased infant carrying throughout the day (besides during feeding and in response to crying) does not seem to reduce infant crying.[50] Also, a car ride simulator was not effective for reducing crying.[51] Alternatively, one study found that reduced stimulation of the infant (by not lifting and patting the baby “excessively,” and giving the infant time to fall asleep on its own despite “a certain amount of crying”) may be effective to reduce colic; however, this study suffered from serious methodological flaws, reducing confidence in its findings.[52] Overall, evidence across each of these interventions was rated as low quality.[10] Besides the infant, it is important to assess and treat caregiver depression, anxiety, and/or exhaustion. Otherwise, colic can lead to adversarial or alienated feelings toward the unsoothable infant; it increases the risk of shaken infant syndrome and other forms of abuse, which can be clinical emergencies.[4] Importantly, caregivers should be educated on the self-limiting nature of colic, and taught that the vast majority of the time, colic is neither due to disease nor anything the caregivers have done, or not done, to their infants. Caregivers should be advised to try not to exhaust themselves, and if possible, to regularly leave their infants with others in their support network in order to have breaks.[53][13]

What causes infantile colic?

While the cause of colic has not been established, there are several different factors that may contribute. These include gastrointestinal factors (such as gut flora, food intolerances, feeding frequency, inflammation and gastrointestinal immaturity), neurodevelopmental factors (such as increased intestinal motility), and drug-based factors (such as maternal smoking). Interactions between some of these factors are likely as well.[10][27]

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References
  1. ^Ellwood J, Draper-Rodi J, Carnes DComparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines.BMJ Open.(2020-Feb-25)
  2. ^Landgren K, Hallström IParents' experience of living with a baby with infantile colic--a phenomenological hermeneutic study.Scand J Caring Sci.(2011-Jun)
  3. ^Gordon M, Gohil J, Banks SSParent training programmes for managing infantile colic.Cochrane Database Syst Rev.(2019-Dec-03)
  4. ^Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko SChildhood Functional Gastrointestinal Disorders: Neonate/Toddler.Gastroenterology.(2016-Feb-15)
  5. ^Johnson JD, Cocker K, Chang EInfantile Colic: Recognition and Treatment.Am Fam Physician.(2015-Oct-01)
  6. ^Freedman SB, Al-Harthy N, Thull-Freedman JThe crying infant: diagnostic testing and frequency of serious underlying disease.Pediatrics.(2009-Mar)
  7. ^Savino F, Pelle E, Castagno E, Palumeri E, Oggero RMust infants with colic really be hospitalized?Acta Paediatr.(2007-Jul)
  8. ^Savino F, Tarasco VNew treatments for infant colic.Curr Opin Pediatr.(2010-Dec)
  9. ^Lucas A, St James-Roberts ICrying, fussing and colic behaviour in breast- and bottle-fed infants.Early Hum Dev.(1998-Nov)
  10. ^Camilleri M, Park SY, Scarpato E, Staiano AExploring hypotheses and rationale for causes of infantile colic.Neurogastroenterol Motil.(2017-Feb)
  11. ^Gordon M, Biagioli E, Sorrenti M, Lingua C, Moja L, Banks SS, Ceratto S, Savino FDietary modifications for infantile colic.Cochrane Database Syst Rev.(2018-Oct-10)
  12. ^Wolke D, Bilgin A, Samara MSystematic Review and Meta-Analysis: Fussing and Crying Durations and Prevalence of Colic in Infants.J Pediatr.(2017-Jun)
  13. ^Savino FFocus on infantile colic.Acta Paediatr.(2007-Sep)
  14. ^Korpela K, Renko M, Paalanne N, Vänni P, Salo J, Tejesvi M, Koivusaari P, Pokka T, Kaukola T, Pirttilä AM, Tapiainen TMicrobiome of the first stool after birth and infantile colic.Pediatr Res.(2020-Nov)
  15. ^Pärtty A, Kalliomäki M, Salminen S, Isolauri EInfantile Colic Is Associated With Low-grade Systemic Inflammation.J Pediatr Gastroenterol Nutr.(2017-May)
  16. ^Rhoads JM, Fatheree NY, Norori J, Liu Y, Lucke JF, Tyson JE, Ferris MJAltered fecal microflora and increased fecal calprotectin in infants with colic.J Pediatr.(2009-Dec)
  17. ^Rhoads JM, Collins J, Fatheree NY, Hashmi SS, Taylor CM, Luo M, Hoang TK, Gleason WA, Van Arsdall MR, Navarro F, Liu YInfant Colic Represents Gut Inflammation and Dysbiosis.J Pediatr.(2018-Dec)
  18. ^WESSEL MA, COBB JC, JACKSON EB, HARRIS GS, DETWILER ACParoxysmal fussing in infancy, sometimes called colic.Pediatrics.(1954-Nov)
  19. ^Biagioli E, Tarasco V, Lingua C, Moja L, Savino FPain-relieving agents for infantile colic.Cochrane Database Syst Rev.(2016-Sep-16)
  20. ^Weissbluth M, Christoffel KK, Davis ATTreatment of infantile colic with dicyclomine hydrochloride.J Pediatr.(1984-Jun)
  21. ^Hall B, Chesters J, Robinson AInfantile colic: a systematic review of medical and conventional therapies.J Paediatr Child Health.(2012-Feb)
  22. ^Savino F, Brondello C, Cresi F, Oggero R, Silvestro LCimetropium bromide in the treatment of crisis in infantile colic.J Pediatr Gastroenterol Nutr.(2002-Apr)
  23. ^Lucassen PColic in infants.BMJ Clin Evid.(2010-Feb-05)
  24. ^Moore DJ, Tao BS, Lines DR, Hirte C, Heddle ML, Davidson GPDouble-blind placebo-controlled trial of omeprazole in irritable infants with gastroesophageal reflux.J Pediatr.(2003-Aug)
  25. ^Di Lorenzo, COther Functional Gastrointestinal Disorders in Infants and Young ChildrenPediatric Gastroenterology and Nutrition.(December 2013)
  26. ^Gieruszczak-Białek D, Konarska Z, Skórka A, Vandenplas Y, Szajewska HNo effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials.J Pediatr.(2015-Mar)
  27. ^Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AKProbiotics to prevent infantile colic.Cochrane Database Syst Rev.(2019-Mar-13)
  28. ^Underwood MAShould we treat every infant with a probiotic?Minerva Pediatr.(2019-Jun)
  29. ^Skonieczna-Żydecka K, Janda K, Kaczmarczyk M, Marlicz W, Łoniewski I, Łoniewska BThe Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.J Clin Med.(2020-Apr-02)
  30. ^Liu Y, Ma D, Wang X, Fang YProbiotics in the treatment of infantile colic: a meta-analysis of randomized controlled trials.Nutr Hosp.(2022-Oct-17)
  31. ^Sung V, D'Amico F, Cabana MD, Chau K, Koren G, Savino F, Szajewska H, Deshpande G, Dupont C, Indrio F, Mentula S, Partty A, Tancredi Dto Treat Infant Colic: A Meta-analysis.Pediatrics.(2018-Jan)
  32. ^Dryl R, Szajewska HProbiotics for management of infantile colic: a systematic review of randomized controlled trials.Arch Med Sci.(2018-Aug)
  33. ^Dos Reis Buzzo Zermiani AP, de Paula Soares ALPP, da Silva Guedes de Moura BL, Miguel ERA, Lopes LDG, de Carvalho Scharf Santana N, da Silva Santos T, Demarchi IG, Teixeira JJEvidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis.Complement Ther Med.(2021-Dec)
  34. ^F Savino, S Ceratto, E Poggi, M E Cartosio, L Cordero di Montezemolo, A GiannattasioPreventive effects of oral probiotic on infantile colic: a prospective, randomised, blinded, controlled trial using Lactobacillus reuteri DSM 17938Benef Microbes.(2015)
  35. ^Tracy Harb, Misa Matsuyama, Michael David, Rebecca J HillInfant Colic-What works: A Systematic Review of Interventions for Breast-fed InfantsJ Pediatr Gastroenterol Nutr.(2016 May)
  36. ^, Lavalle L, Sauvageot N, Cercamondi CI, Egli D, Jankovic I, Vandenplas YInfant feeding practice and gastrointestinal tolerance: a real-world, multi-country, cross-sectional observational study.BMC Pediatr.(2022-Dec-14)
  37. ^Irina Alexandrovich, Olga Rakovitskaya, Elena Kolmo, Tatyana Sidorova, Sergei ShushunovThe effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled studyAltern Ther Health Med.(2003 Jul-Aug)
  38. ^Arikan D, Alp H, Gözüm S, Orbak Z, Cifçi EKEffectiveness of massage, sucrose solution, herbal tea or hydrolysed formula in the treatment of infantile colic.J Clin Nurs.(2008-Jul)
  39. ^Savino F, Cresi F, Castagno E, Silvestro L, Oggero RA randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants.Phytother Res.(2005-Apr)
  40. ^Johnson JD, Cocker K, Chang EInfantile Colic: Recognition and Treatment: AAFPAm Fam Physician.(Sept 2015)
  41. ^Lucassen PL, Assendelft WJ, Gubbels JW, van Eijk JT, Douwes ACInfantile colic: crying time reduction with a whey hydrolysate: A double-blind, randomized, placebo-controlled trial.Pediatrics.(2000-Dec)
  42. ^Savino F, Palumeri E, Castagno E, Cresi F, Dalmasso P, Cavallo F, Oggero RReduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula.Eur J Clin Nutr.(2006-Nov)
  43. ^Lucassen PColic in infants.BMJ Clin Evid.(2015-Aug-11)
  44. ^, Agostoni C, Axelsson I, Goulet O, Koletzko B, Michaelsen KF, Puntis J, Rieu D, Rigo J, Shamir R, Szajewska H, Turck DSoy protein infant formulae and follow-on formulae: a commentary by the ESPGHAN Committee on Nutrition.J Pediatr Gastroenterol Nutr.(2006-Apr)
  45. ^Perry R, Leach V, Penfold C, Davies PAn overview of systematic reviews of complementary and alternative therapies for infantile colic.Syst Rev.(2019-Nov-11)
  46. ^Hill DJ, Roy N, Heine RG, Hosking CS, Francis DE, Brown J, Speirs B, Sadowsky J, Carlin JBEffect of a low-allergen maternal diet on colic among breastfed infants: a randomized, controlled trial.Pediatrics.(2005-Nov)
  47. ^Dobson D, Lucassen PL, Miller JJ, Vlieger AM, Prescott P, Lewith GManipulative therapies for infantile colic.Cochrane Database Syst Rev.(2012-Dec-12)
  48. ^Cabanillas-Barea S, Jiménez-Del-Barrio S, Carrasco-Uribarren A, Ortega-Martínez A, Pérez-Guillén S, Ceballos-Laita LSystematic review and meta-analysis showed that complementary and alternative medicines were not effective for infantile colic.Acta Paediatr.(2023-Jul)
  49. ^Côté P, Hartvigsen J, Axén I, Leboeuf-Yde C, Corso M, Shearer H, Wong J, Marchand AA, Cassidy JD, French S, Kawchuk GN, Mior S, Poulsen E, Srbely J, Ammendolia C, Blanchette MA, Busse JW, Bussières A, Cancelliere C, Christensen HW, De Carvalho D, De Luca K, Du Rose A, Eklund A, Engel R, Goncalves G, Hebert J, Hincapié CA, Hondras M, Kimpton A, Lauridsen HH, Innes S, Meyer AL, Newell D, O'Neill S, Pagé I, Passmore S, Perle SM, Quon J, Rezai M, Stupar M, Swain M, Vitiello A, Weber K, Young KJ, Yu HThe global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature.Chiropr Man Therap.(2021-Feb-17)
  50. ^R G Barr, S J McMullan, H Spiess, D G Leduc, J Yaremko, R Barfield, T E Francoeur, U A HunzikerCarrying as colic "therapy": a randomized controlled trialPediatrics.(1991 May)
  51. ^Parkin PC, Schwartz CJ, Manuel BARandomized controlled trial of three interventions in the management of persistent crying of infancy.Pediatrics.(1993-Aug)
  52. ^McKenzie STroublesome crying in infants: effect of advice to reduce stimulation.Arch Dis Child.(1991-Dec)
  53. ^Lucassen PL, Assendelft WJ, Gubbels JW, van Eijk JT, van Geldrop WJ, Neven AKEffectiveness of treatments for infantile colic: systematic review.BMJ.(1998-May-23)
  54. ^Nocerino R, Pezzella V, Cosenza L, Amoroso A, Di Scala C, Amato F, Iacono G, Canani RBThe controversial role of food allergy in infantile colic: evidence and clinical management.Nutrients.(2015-Mar-19)
  55. ^Fiocchi A, Brozek J, Schünemann H, Bahna SL, von Berg A, Beyer K, Bozzola M, Bradsher J, Compalati E, Ebisawa M, Guzman MA, Li H, Heine RG, Keith P, Lack G, Landi M, Martelli A, Rancé F, Sampson H, Stein A, Terracciano L, Vieths SWorld Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines.World Allergy Organ J.(2010-Apr)
  56. ^Ralf G HeineGastroesophageal reflux disease, colic and constipation in infants with food allergyCurr Opin Allergy Clin Immunol.(2006 Jun)
  57. ^Merras-Salmio L, Pelkonen AS, Kolho KL, Kuitunen M, Mäkelä MJCow's milk-associated gastrointestinal symptoms evaluated using the double-blind, placebo-controlled food challenge.J Pediatr Gastroenterol Nutr.(2013-Sep)
  58. ^F Savino, L Cordisco, V Tarasco, R Calabrese, E Palumeri, D MatteuzziMolecular identification of coliform bacteria from colicky breastfed infantsActa Paediatr.(2009 Oct)
  59. ^Oosterloo BC, van Elburg RM, Rutten NB, Bunkers CM, Crijns CE, Meijssen CB, Oudshoorn JH, Rijkers GT, van der Ent CK, Vlieger AMWheezing and infantile colic are associated with neonatal antibiotic treatment.Pediatr Allergy Immunol.(2018-Mar)
  60. ^Duong QA, Pittet LF, Curtis N, Zimmermann PAntibiotic exposure and adverse long-term health outcomes in children: A systematic review and meta-analysis.J Infect.(2022-Sep)
  61. ^Høgdall CK, Vestermark V, Birch M, Plenov G, Toftager-Larsen KThe significance of pregnancy, delivery and postpartum factors for the development of infantile colic.J Perinat Med.(1991)
  62. ^Hashemi A, Villa CR, Comelli EMProbiotics in early life: a preventative and treatment approach.Food Funct.(2016-Apr)
  63. ^Zhou L, Qiu W, Wang J, Zhao A, Zhou C, Sun T, Xiong Z, Cao P, Shen W, Chen J, Lai X, Zhao LH, Wu Y, Li M, Qiu F, Yu Y, Xu ZZ, Zhou H, Jia W, Liao Y, Retnakaran R, Krewski D, Wen SW, Clemente JC, Chen T, Xie RH, He YEffects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial.Cell Host Microbe.(2023-Jul-12)
  64. ^de Weerth C, Fuentes S, de Vos WMCrying in infants: on the possible role of intestinal microbiota in the development of colic.Gut Microbes.(2013)
  65. ^Maria G Dominguez-Bello, Elizabeth K Costello, Monica Contreras, Magda Magris, Glida Hidalgo, Noah Fierer, Rob KnightDelivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newbornsProc Natl Acad Sci U S A.(2010 Jun 29)
  66. ^Kamphorst K, Carpay NC, de Meij TGJ, Daams JG, van Elburg RM, Vlieger AMClinical outcomes following pre-, pro- and synbiotic supplementation after caesarean birth or antibiotic exposure in the first week of life in term born infants: A systematic review of the literature.Front Pediatr.(2022)
  67. ^Hofman D, Kudla U, Miqdady M, Nguyen TVH, Morán-Ramos S, Vandenplas YFaecal Microbiota in Infants and Young Children with Functional Gastrointestinal Disorders: A Systematic Review.Nutrients.(2022-Feb-25)
  68. ^Kirjavainen J, Jahnukainen T, Huhtala V, Lehtonen L, Kirjavainen T, Korvenranta H, Mikola H, Kero PThe balance of the autonomic nervous system is normal in colicky infants.Acta Paediatr.(2001-Mar)
  69. ^Milidou I, Henriksen TB, Jensen MS, Olsen J, Søndergaard CNicotine replacement therapy during pregnancy and infantile colic in the offspring.Pediatrics.(2012-Mar)
  70. ^McCreedy A, Bird S, Brown LJ, Shaw-Stewart J, Chen YFEffects of maternal caffeine consumption on the breastfed child: a systematic review.Swiss Med Wkly.(2018-Sep-24)
  71. ^Iacono G, Merolla R, D'Amico D, Bonci E, Cavataio F, Di Prima L, Scalici C, Indinnimeo L, Averna MR, Carroccio A,Gastrointestinal symptoms in infancy: a population-based prospective study.Dig Liver Dis.(2005-Jun)
Examine Database References
  1. Infant crying - Francesco Savino, Emanuela Pelle, Elisabetta Palumeri, Roberto Oggero, Roberto MinieroLactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized studyPediatrics.(2007 Jan)
  2. Infant crying - Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, Heine RG, Stock A, Barr RG, Wake MTreating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trialBMJ.(2014 Apr 1)
  3. Infant crying - Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, Roos S, Matteuzzi DLactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trialPediatrics.(2010 Sep)
  4. Infant crying - Roos S, Dicksved J, Tarasco V, Locatelli E, Ricceri F, Grandin U, Savino F454 pyrosequencing analysis on faecal samples from a randomized DBPC trial of colicky infants treated with Lactobacillus reuteri DSM 17938PLoS One.(2013)
  5. Infant crying - Sung V, Collett S, de Gooyer T, Hiscock H, Tang M, Wake MProbiotics to prevent or treat excessive infant crying: systematic review and meta-analysisJAMA Pediatr.(2013 Dec)
  6. Infant crying - Szajewska H, Gyrczuk E, Horvath ALactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trialJ Pediatr.(2013 Feb)
  7. Infant crying - Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, Ballardini E, Bisceglia M, Cinquetti M, Brazzoduro E, Del Vecchio A, Tafuri S, Francavilla RProphylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trialJAMA Pediatr.(2014 Mar)