Glycogen Content

Your body has two ways to store the carbs you eat. It can transform them into fat, in a process called de novo lipogenesis (DNL), but first it’ll want to refill its glycogen stores in the liver and skeletal muscle.

Your body uses your liver for short-term storage of glycogen. When you fast (which most of you do overnight as you sleep), your liver is where your brain will first search for the glucose it needs to keep functioning. After a fast of 12–16 hours, when liver stores are 25–50% depleted, each kilogram of the average liver still contains 44 grams of glycogen (range: 14–80 g),^[1] so we can estimate the maximal capacity of the average liver at 60–90 g/kg.

Glycogen, moreover, cannot be stored on its own: it must be bound to water. In your liver, each gram of glycogen comes along with 2.4 grams of water.^[2]

^[3][4][1] 

When full of glycogen, the average, healthy, human-male liver is heavier by 289–432 grams (0.6–1.0 lb), whereas the average, healthy, human-female liver is heavier by 241–364 grams (0.5–0.8 lb).

Glycogen also gets stored in your muscles.

^[5]

Of course, typical muscle mass varies greatly between individual men (22–40 kg, typically) and women (15–30 kg).^[6] By combining those numbers with an estimation of the muscles’ average glycogen content (11.7 g/kg), we can further estimate that, in their muscles, men carry 256–466 grams of glycogen, and women 175–350 grams.

As we saw however, glycogen cannot be stored on its own: it must be bound to water. In your muscles, each gram of glycogen comes along with at least 3 grams of water,^[7] which can become 17 grams if you co-ingest a lot of fluid and a lot of carbs after exercising in a hot, dry environment.^[7]

Therefore, in normal circumstances, a man who carries 31 kilograms of muscles (68 lb) also carries in those muscles 361 grams of glycogen and 1,083 grams of water (0.8 and 2.4 lb). And if he drinks a lot while ingesting his carbs, as is often the case during a feast, he may end up carrying much more.

Likewise, in normal circumstances, a woman who carries 23 kilograms of muscles (51 lb) also carries in those muscles 268 grams of glycogen and 804 grams of water (0.6 and 1.8 lb). And if she drinks a lot while ingesting her carbs, as is often the case during a feast, she may end up carrying much more.

If you drink a lot and ingest a lot of carbs, as is likely during a feast, your muscles might gain several pounds of water weight.

Compared to sedentary people, athletes have more muscle and can better synthesize and store glycogen.^[8][9] A small study found the maximal storage capacity of its subjects (three male collegiate athletes) to be 629–1,146 grams, with an average of 810 grams.^[10] That’s way more than the 341–593 grams (85–127 in the liver, 256–466 in the muscles, as we saw previously) carried by the average man.

Note that, to reach those numbers, the athletes followed a specific protocol: the first three days, they depleted their glycogen stores with exercise and a low-carbohydrate diet; then, for each of the next seven days, they consumed 3,500–5,000 calories, of which 80–90% came from carbs (760–990 grams). On the first day of this week-long binge, all the extra energy served to refill glycogen stores; the athletes didn’t gain any fat. On the second day, fat synthesis amounted to only 30 grams. On the third day, to only 45 grams.

At the end of this week-long binge, the athletes had gained 4.6 kg (10.1 lb) on average, of which 1.1 kg (2.5 lb) was fat. Only half of this fat came from the enormous amount of carbs consumed; the other half came from the proportionally little fat consumed.

Glycogen depletion through diet and exercise on the days leading to a feast can help buffer the caloric load of any carbohydrates being eaten, and therefore help minimize fat gain.

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect glycogen content.

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Level of Evidence ? The amount of high quality evidence. The more evidence, the more we can trust the results.	Supplement	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
	Chromium	-	- See study	Similar to the failure in increasing glycogen replenishment rate, the overall glycogen content increased by carbohydrate is not altered by supplementation of chromium.
	Creatine	-	- See 2 studies
	Resveratrol	-	- See study	150mg resveratrol taken shortly after a workout appears does not appear to influence muscular glycogen content at rest.