Summary of Taraxacum officinale
Primary Information, Benefits, Effects, and Important Facts
Taraxacum officinale, also known as dandelion, is a vegetable that most people call a weed. Dandelion is sometimes used as a salad green, and has limited traditional use in East Asian countries. It is used around the world for its diuretic effect.
Though dandelion is ingested primarily as a diuretic, there is a lack of good human evidence for this effect.
Animal studies and in vitro evidence suggest dandelion may have a variety of other beneficial health effects, but much more research is needed to trace these effects back to individual compounds found in dandelions. Since many of the compounds found in dandelions can be found in other herbs, it is possible that other supplements may be more effective than dandelion.
Limited rodent evidence suggests dandelion may be able to ease digestion by increasing the rate at which food leaves the stomach and enters the small intestine. Dandelion may also exert a protective effect on the pancreas. Preliminary evidence suggests dandelion may have minor antiallergenic properties, but further research is needed to confirm this effect.
Dandelion can be used in salad. About 100 g of dandelion provides about 10-15% of your daily potassium requirements, at little to no caloric intake. Supplementation of dandelion cannot be recommended at this time due to a lack of human evidence for its effects. Consuming wild dandelions is not recommended, especially those grown in urban and suburban settings, as they will have been exposed to pesticide.
Things To Know & Note
Is a Form Of
Also Known As
Dandelion, Dandelion extract, Pisselent, Piss-in-bed, priest's crown, lion's teeth, lion's tooth, milk daisy, huang hua di ding, dumble-dor, white endive, wild endive
Do Not Confuse With
Yamabushitake (Lion's mane, rather than lion's tooth which is what dandelion is sometimes called)
Caution NoticeExamine.com Medical Disclaimer
Dandelions grown in urban and suburban settings may have been exposed to pesticides given their status as a weed, so consuming wild dandelions is not advised
Potential adverse interaction with ciprofloxacin by reducing its absorption
How to Take Taraxacum officinale
Recommended dosage, active amounts, other details
About 100 g of dandelion can be using in a salad to provide 10-15% of your daily potassium requirement.
The dose above is equivalent to approximately 10g of the dry weight of the plant, assuming water content of 87-90%.
Supplementation of dandelion cannot be recommended at this time due to a lack of human evidence for its effects. Consuming wild dandelions is not recommended, especially those grown in urban and suburban settings, as they will have been exposed to pesticide.
Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects taraxacum officinale has on your body, and how strong these effects are.
|Grade||Level of Evidence [show legend]|
|Robust research conducted with repeated double-blind clinical trials|
|Multiple studies where at least two are double-blind and placebo controlled|
|Single double-blind study or multiple cohort studies|
|Uncontrolled or observational studies only|
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|Diuresis||Minor||- See study|
Studies Excluded from Consideration
Confounded with other herbs
Scientific Research on Taraxacum officinale
Click on any below to expand the corresponding section. Click on to collapse it.
Taraxacum officinale (of the family Asteraceae) is the botanical name for the common dandelion, commonly considered an invasive plant species and botanically related to chicory. The genus of Taraxacum comprises types of dandelion, with other species that have been used traditionally or medicinally including taraxacum mongolicum (Chinese kidney formulation) and Taraxicum coreanum with the species known as Taraxacum erythrospermum also being considered a weed like officinale. Other popular names for this plant include the french name pisselent (in reference to its diuretic properties), lion's tooth, and milk daisy.
It has some traditional usage in Korean medicine for improving general health and energy levels and some other uses such as a cholerectic, for treatment of rheumatism, and lactation aid but is most commonly known for its traditional usage as a diuretic today.
Dandelion is a plant most commonly known overall for being an invasive plant species, but medicinally is sometimes used for various general health purposes such as vitality and the treatment of a wide range of inflammatory conditions. Most practically and most prolifically, it is used as a diuretic.
Dandelion is known to contain:
Eudesmanolides (sesquiterpene lactones) and their glucosides, formerly collectively known as taraxacum and found in most dandelion species including officinale contributing to their bitter taste and likely its allergenic potential. Ones found in Taraxacum officinale include 4-O-β-D-glucosyl-11,13-dihydro-taraxinic acid and 14-O-β-D-glucosyl-taraxinic acid.
The pentacyclic terpenoid known as taraxasterol, considered a main bioactive of dandelion and named after its genus (Taraxacum) although fairly ubiquitous as it can be found in other herbs such as Eupatorium azureum, Stevia berlandieri, Capparis sepiaria, and Cirsium texanum
Chicoric acid (Named after chicory, a botanically related herb to dandelion) at 18.9µg/g in a hot water extract of the aerial parts of the plant and a higher content (128.6µg/g) in a methanolic extract. The plant itself appears to have 14.91mg/g dry weight of the leaves, 13.79mg/g in the flowers, and a mere 2.71mg/g in the roots
Luteolin at 4.80µg/g (leaves) and as 7-O-glucoside (990µg/g dry weight in leaves with none detectable in roots.) Extracts of dandelion have found 3.53µg/g in the water extract but a higher concentration of 34.2µg/g in a methanolic extract while ethyl acetate extracts may be up to 10% luteolin plus luteolin-7-O-glucoside collectivley
Isovitexin at 870µg/g in leaves only and vitexin as 2-rhamnoside at 150-990µg/g in roots and higher at 2.07mg/g in the leaves
Kynurenic acid at 0.05+/-0.01µg/g (root)
Phenylacetic acid derivatives (root)
Sodium at 0.49% and 0.33% of the leaves and roots respectively
Copper in varying concentrations (depending on the soil it is grown in) of 15-97µg/g (roots) and 15-52µg/g (leaves), about half of the soil content of copper and well correlated with the soil content
Manganese in varying concentrations (depending on the soil it is grown in) of 43-115µg/g (roots) and 32-98µg/g (leaves)
Lead in varying concentrations (depending on the soil it is grown in) of up to 155µg/g (roots) and up to 28µg/mL (leaves), with some samples showing negligible content
There are a wide variety of molecules found in dandelion which, for the most part, are not unique nor high enough to put this herb above others that have higher concentrations of the same flavonoids or potent unique molecules. Of the ones in dandelion which may be potent and unique we have two polysaccharides (TOP1 and TOP2) which are likely present in the water extract amongst other things, and some sesquiterpenes that may contribute to the effects of ethanolic extracts
The overall flavonoid content of dandelion is higher in the dry leaf extract (27.32mg/g or 2.7%, although other studies have found significantly lower levles of 8mg/g chlorogenic acid equivalents) than in root extracts (3.03-3.10mg/g or 0.3%) and a hot water extract (three subsequent extractions at 100°C in 200mL of water for 3 hours, 150mL for 2 hours, and 100mL for a final hour) yields 17% of the dandelion's initial dry weight as the water soluble extract. The overall phenolic content has been measured (in an ethanolic extract) to be 195.4+/-3.6mg/g, with its antioxidant capacity 40% that of an equivalent concentration of Vitamin C and 20% that of pure gallic acid.
Hot water extracts have been noted to have 0.167% flavonoids, 0.134% coumarins, 1.672% total hydroxycinnamic acid derivatives, and 2.364% terpenoids.
Ethanolic extracts will confer more flavonoids than do the water extracts, although even when this happens the overall antioxidant effect is not greater than references (vitamin C and gallic acid) suggesting moderate to low antioxidant capacity; the hot water extract appears to have lower antioxidant potential.
Dandelion is known to accumulate heavy metals from the soil and can be used as a biomarker of mineral content of the soil, with copper concentrations increasing in a linear manner.
While dandelion was not seen to upregulate many cytochrome levels (CYP2D, CYP3A, and total CYP) after four weeks dandelion tea ingestion (2% w/v), there was a reduction in the kinetic capacity of CYP1A2 to less than 25% of control, nonsignificantly greater than peppermint tea and chamomile at the same dose (green tea ineffective) while CYP2E was affected to a lesser degree (50% of control, similar to peppermint) and CYP2D and CYP3A were not affected by dandelion tea.
There is a potential concerning inhibition of CYP1A2 which may lead to some drug-drug interactions associated with dandelion extract, while two other common enzymes (CYP2D and CYP3A) appear to not be affected; more research is needed.
A tea solution of dandelion (2% w/v) failed to have any influence on hepatic glutathione S-transferase (GST) activity when given to rats over the course of four weeks, although the tea appeared to increase the activity of UDP-glucuronosyl transferase to 244% of control.
A large increase in one enzyme responsible for elimination of some drugs and supplements (those eliminated via glucuronidation) may mean a potential 'detoxifying' effect has basis. The antioxidant enzyme GST which is also involved in drug metabolism does not appear affected.
Although another species was used, dandelion (Taraxacum mongolicum) has been noted to reduce the bioavailability of the antibiotic drug known as ciprofloxacin when given a high oral dose (2g/kg) of the hot water extract, reducing both the max plasma concentration (by 73%) and the half life (from 5.71 hours to 1.96 hours).
One species of dandelion may interact with ciprofloxacin, it is not sure if this applies to the common species (officinale).
Dandelion has been used in a rat study using a forced swim test model of depression (alongside other behavioral tests), which noted that 50-200mg/kg of a hot water extract of the leaves had efficacy after two weeks of usage by reducing immobility time, whereas acute usage of 200mg/kg only was effective (acute usage of 50 and 100mg/kg ineffective) at the same thing; these effects appeared to be associated with decreased serum corticotrophin releasing factor (CRF) and corticosterone.
A single rat study indicates that dandelion extract in water may have antidepressant effects in mice. These results have not yet been replicated in humans or using other animal behavioral models of depression.
Dandelion has been found to have inhibitory actions on porcine pancreatic lipase with 250µg/mL of this extract inhibiting 86.3% lipase activity in vitro (IC50 of 78.2µg/mL), which was comparable to Orlistat at the same concentration, although Orlistat had a much more potent IC50 (0.22µg/mL). When 400mg/kg dandelion extract was fed to mice alongside fatty acids, the area under the curve (AUC, representing the total bodily exposure to a substance) of absorbed fatty acids over the next four hours was reduced by 23%.
A rat study suggests that dandelion extract, when co-ingested with fat, may reduce fat absorption, although it is less potent than the over-the-counter drug Orlistat.
Injections of dandelion hydroalcoholic extract (50-200mg/kg) in mice for 20 days noted that the two higher tested doses (100-200mg/kg) were able to mildly increase red blood cell (RBC) count and mean hemoglobin concentrations relative to control.
Injections of dandelion hydroalcoholic extract (50-200mg/kg) in mice for 20 days noted that all doses were equipotent at reducing platelet concentrations by approximately 10% (data derived from graph).
Dandelion root and leaf extracts have once shown cholesterol reducing properties when given as 1% (w/w) of the diet to rabbits fed a high-cholesterol diet; both the root and leaf extracts reduced triglyceride levels, while only the leaf extract raised healthy HDL levels while lowering unhealthy LDL levels (the root had no effect on HDL level and actually raised LDL levels further).
One rabbit study indicates that dandelion leaf extract may benefit lipid levels in animals fed a high-cholesterol diet.
Hot water extracts of dandelion have been noted to have minor inhibitory actions towards α-glucosidase, an enzyme that increases absorption of glucose by cleaving it from disaccharides and starch, when tested in 3 sources of α-glucosidase in vitro: baker's yeast, rabbit liver, and rabbit intestines. Dandelion extract reduced activity to around 40-80% of control with IC50 values of 2.3mg/mL, 3.5mg/mL, and 1.83mg/mL respectively, but was less potent than the extract from another tested herb, Myrutus communis, and is similar to stinging nettle in potency while underperforming all reference drugs (glimerid, gliclazide, and acarbose).
Hot water extract of dandelion inhibits α-glucosidase (which digests starch) in vitro, which may reduce absorption of carbohydrates. No studies have confirmed whether this would work in vivo, however.
Dandelion root extract was noted to hinder differentiation of 3T3-L1 preadipocytes in vitro by approximately 30% at a concentration of 300-600µg/mL (with no significant difference between concentrations), with a 20-30% reduction in triglyceride accumulation with root extract at 300-600µg/mL (no dose-dependent relationship) and a dose-dependent decrease with leaf extract up to resulting in a 65% reduction in triglyceride levels during differentiation. and an inhibitory effect during adipogenesis with the leaf appearing to be more effective than the root extract. Leaf and root extracts also decreased lipid droplet accumulation by approximately 20% at 600µg/mL.
Dandelion extract hinders fat cell differentiation and lipid and triglyceride accumulation in vitro, with leaf extract being more potent in the latter function. Whether this would lead to reduced fat mass in vivo has not yet been tested.
Dandelion extract at high concentrations in vitro (400-800µg/mL) increased glucose uptake in C2C12 myotubes secondary to AMP-activated protein kinase (AMPK) activation, a protein which senses the energy level of cells and whose activation may reduce fatty liver and glucose tolerance; although dandelion extract did this to a lower level than the reference drug rosiglitazone, a PPAR-γ agonist. An increase in AMPK phosphorylation was noted after 10 weeks ingestion of a dandelion enriched high fat diet in mice (0.2% w/w of the diet) with no further phosphorylation occurring at 0.5% w/w.
Dandelion extract has been seen to increase in glucose uptake in skeletal msucles in rodents over the course of ten weeks secondary to AMPK activation.
Dandelion water extract at 10 or 100mg/kg in young male mice for ten days caused a dose-dependent reduction in immobility time in a forced swim test (mouse model of both antifatigue and antidepressive effects) with the higher dose (100mg/kg) reaching a significant reduction of immobility time (164+/-7.8s) relative to control (215+/-0.7s) by 24%. This change was associated with reductions in creatine kinase (CK) and lactate dehydrogenase (LDH), which are correlated to fatigue and muscle damage, in serum as well as an increase in serum glucose, although those former two biomarkers were changed to a similar degree in both dandelion doses while glucose increased only at the higher dose by 14%. Another study using the forced swim test and hot water extracts of dandelion found almost dose-dependent benefits between 10-100mg/kg after six weeks administration alongside increases in serum glucose and reductions in serum triglycerides.
Due to the exclusive usage of the forced swim test in rats and potential antidepressant effects of dandelion shown via this test it cannot yet be assumed dandelion possesses ergogenic properties as opposed to antidepressant properties.
An antifatigue effect of dandelion has been noted in mice subject to a forced swim test, although the results may be confounded by that test also measuring antidepressant effects. Influence of supplementation on other parameters of endurance exercise (such as treadmill running, usually a better model for ergogenic aids) remain untested.
Taraxasterol, one of the major bioactive components of dandelion, has anti-inflammatory properties in vitro. Since the inflammatory cytokine IL-1β may play a role in the cartilage degradation seen in osteoarthritis, taraxasterol was studied in vitro to assess its effects on IL-1β-stimulated chondrocytes.
One in vitro study found that taraxasterol dose-dependently inhibited IL-1β-induced NF-κB activation in human chondrocytes at concentration of up to 10 μg/mL. It has been previously shown that IL-1β normally works through NF-κB in chondrocytes to upregulate inflammatory mediators such as COX-2 and various matrix metalloproteinases (MMPs) which degrade cartilage and may contribute to osteoarthritis. It was found that taraxasterol blocked this process and downregulated production of COX-2 and MMPs in human chondrocytes, suggesting that it could theoretically slow the progression of osteoarthritis. However, this hypothesis has yet to be confirmed in either animal or human studies.
Injections of 200mg/kg of the hydroalcoholic extract of dandelion in mice for 20 days has resulted in an increase in average white blood cell (WBC) count relative to control, with 50-100mg/kg not having a significant effect, while the percentage lymphocytes in all groups saw a small increase due to a slight decrease in neutrophil count.
In vitro, macrophages treated with dandelion extract at 1mg/mL appear to secrete more tumor necrosis factor-α (TNF-α) and interleukin-12p70 (IL-12p70) in response to treatment with IFN-γ when incubated for both one hour and 24 hours to a similar degree, although lower concentrations (10µg/mL and 100µg/mL) were ineffective. All concentrations increased NO production in macrophages stimulated with interferon-γ (IFN-γ) thought to be secondary to an induction of inducible nitric oxide synthase (iNOS).
IL-10 production from IFN-γ was also enhanced in vitro at 100µg/mL and 1mg/mL, and were promoted inherently (i.e. without IFN-γ) at the higher concentration.
Moderate to high concentrations of dandelion extract appear to have a costimulatory effect on macrophages when in the presence of a stimulatory agent (IFN-γ), suggesting a possible proimmunity effect.
Dandelion extracts have been noted to suppress lipopolysaccharide (LPS)-induced inflammation when tested in vitro in macrophages, with a methanolic extract being more potent (IC50 of 79.9µg/mL) than a water extract (157.6µg/mL), and with both leading to a reduction in lipid peroxidation and inflammatory signalling (iNOS induction and NF-kB activation) being noted. Benefits have been replicated elsewhere with leaf extracts where a chloroform extract showed the most efficacy in hindering nitric oxide production (more than an n-butanolic extract, which has been shown to be best in another study which did not assess chloroform extracts), IL-6, and PGE2 formation at 62.5µg/mL while a water extract was ineffective at all doses up to 250µg/mL in this study.
The bioactive taraxasterol, which can be isolated from dandelion, appears to suppress the inflammation response of macrophages, with incubation of macrophages with 2.5-12.5μg/mL prior to LPS introduction suppressing iNOS and COX2 expression relative to LPS control. Polysaccharides isolated from dandelion have had similar effects when tested in isolation, suggesting that multiple compounds from dandelion may be antiinflammatory. While minor constituents, both luteolin and chicoric acid found in dandelion are bioactive on their own but have been noted to have synergistic properties in inhibiting macrophage stimulation, and thus may also contribute to dandelion's antiinflammatory properties. The higher levels of chicoric acid and luteolin in the methanolic extract of dandelion may explain its higher potency relative to the water extract.
With regard to LPS stimulation of macrophages, which is a commonly used assessment for inflammation, various components in dandelion appear to have a suppressive (antiinflammatory) effect.
In neutrophils activated by the ion-carrier A23187, the methanolic extract from the root of dandelion has been noted to have 90% inhibitory action (with respect to leukotriene B4 formation) at a concentration of 3µg/mL, thought to be due to the sesquiterpene lactone content.
One study noted relatively potent suppression of neutrophils in vitro.
Taraxasterol isolated from dandelion was seen to have antiallergic properties in ovalbumin (OVA)-sensitized mice when given for five days at oral doses of 5-10mg/kg (with 2.5mg/kg being ineffective), with 10mg/kg being as effective in reducing white blood cell content in bronchoalveolar lavage fluid as the reference drug (2mg/kg dexamethasone) and was associated with less OVA-specific IgE production.
Dandelion extract itself has shown antiinflammatory properties in a mouse model of lung damage at a similar oral dose (2.5-10mg/kg) associated with reduced white blood cell (neutrophil) infiltration and production of inflammatory cytokines. This result has been replicated by pure taraxasterol at the same dosage range with a potency comparable to 5mg/kg dexamethasone.
There appear to be some protective antiinflammatory effects in the lung of mice seen with both taraxasterol and low levels of dandelion ingestion. This potential benefit requires human testing to confirm a role for dandelion in allergic conditions.
Dandelion hot water extract in peripheral mononuclear blood cells (PMBCs) infected with HIV-1 was able to inhibit viral replication with an IC50 of 640µg/mL, reaching maximum efficacy (98%) at 2mg/mL, and showed more potent inhibitory action (IC50 230µg/mL) against another unrelated retrovirus (10A1-pseudotyped hybrid-MoMuLV/MoMuSV); the reference of AZT had an IC50 of 0.29µM on HIV-1. The inhibitory effect was not thought to be related to the chlorogenic acid or caffeic acid content of the extract, since another tested herb with higher quantities of both (Artemisiae scopariae) had less potent inhibitory action.
Dandelion hot water extract has also been noted to possess anti-influenza properties with an IC50 of 990µg/mL and full inhibition occuring at 5mg/mL, which was significantly weaker than the reference drug Oseltamivir (which exhibited full inhibition at 75µg/mL).
Dandelion shows antiviral properties against HIV and influenza in vitro, but it is significantly weaker than the reference drugs AZT and Oseltamivir, respectively.
While dandelion extract is traditionally used in Jordan as a fertility enhancer, oral ingestion of high doses of dandelion hot water extract (1.065g/kg and 2.13g/kg, a twenthieth and a tenth of the LD50, respectively) for sixty days in male rats appears to actually reduce serum testosterone concentration, secondary to testicular damage.
A high dose (approaching one-tenth of that needed to kill 50 percent of a poplulation of rats) of dandelion has been seen to induce fertility problems in male rats and lower serum testosterone; lower doses (which are normally recommended for supplementation) have not been tested.
Since dandelion has been traditionally used to treat abnominal distension, dyspepsia, nausea, and vomiting, its effect on the stomach has been investigated.
Dandelion ethanolic extracts have been noted to have a promotility effect on the stomach (increase in gastric emptying rate) when ingested at up to 100mg/kg in rats (EC50 of 20.1+/-2.2mg/kg, maximal efficacy in the 50-100 mg/kg range) with a potency comparable to 2mg/kg cisapride as reference; this effect seemed to mediated through cholinergic stimulation (since blockade of the cholinergic, but not adrenergic, system had an effect).
One study noted that dandelion ethanolic extract increased stomach motility in rats.
The leaves and roots of dandelion at 200-600mg/kg appears to confer protective effects in the liver in mouse models of hepatotoxicity from CCl4 and acetominophen secondary to its antioxidant properties, as both of these drugs exert hepatotoxicity via oxidative means. n-hexane extracts are less protective at the same dose which may be due to their lower polyphenolic content compared to ethanolic extracts. Polysaccharides from dandelion (designated TOP1 and TOP2) may also have protective effects against CCl4 at oral doses reflecting around 800mg/kg of a hot water extract in rats. Protective effects have also been noted with a hot water extract at a higher oral dose (1g/kg bodyweight in mice) against alcohol toxicity.
Intake of dandelion extract to mice on a high-fat diet (extract dose of 2g/kg or 5g/kg of the diet) for 10 weeks appeared to attenuate the production of fatty liver and hepatic inflammation and subsequent insulin resistance to a degree, with no significant differences between doses. these doses appeared to be sufficient to increase AMP protein kinase (AMPK) signalling in liver tissue.
Oral ingestion of dandelion at doses comparable to what a human would consume (around 10 grams for a 150lb person) appear to confer some minor protective effects in the liver according to rodent studies; human studies are currently unavailable. The mechanism seems to be due to through dandelion extract's antioxidant properties.
Dandelion hot water extract given orrally at a dose of 10mg/kg following administration of cholecystokinin to induce pancreatitis noted that production of inflammatory cytokines IL-6 and TNF-α was reduced relative to control.
Low doses of dandelion have shown minor protective effects in the pancreas in a rat model of pancreatitis, although no human studies are available.
Dandelion is traditionally used in Chinese and Ayurvedic medicine as a diuretic, a use which led to its name in French being pissenlit to reflect this property. In rodent models, the leaf appears to confer more diuretic potential than does the root with 2 grams of the leaf per kilogram bodyweight in mice (estimated human equivalent of 160mg/kg) having potency comparable to 80mg/kg furosemide, while elsewhere it was found that, in assessing fractions of dandelion extract, only the petroleum ether extract and the methanolic fractions had efficacy wich was significantly lesser than 37.5mg/kg furosemide (dandelion dose based on dry weight not disclosed). It was hypothesized that this diuretic effect is due to the high potassium content in the leaves (4.51%) relative to the low sodium content (0.33% dry weight).
Oral ingestion of a dandelion extract (95% ethanolic extract) equalling about 8g of the fresh plant weight taken three times a day in otherwise healthy subjects was able to increase frequency of urination and overall urine output relative to the day prior to supplementation and the day after (urine output normalized after the third dose in the evening).
The diuretic role of dandelion is currently understudied. While a high potassium content is a probable explanation for a diuretic effect, other components of the extract have not been ruled out. The exact potency of this effect is not known, and while it does appear to work in humans the evidence is very preliminary.
In HepG2 hepatoma cells treated with dandelion extract (8% water extract) at 200-2,000µg/mL for 24-48 hours (with 20µg/mL being ineffective), the extract appeared to reduce viability to 80% of control and increased apoptosis rates, with 200µg/mL increasing apoptosis by 28.7% (24 hours) and 38.8% (48 hours); this increased apoptosis was associated with more tumor necrosis factor alpha (TNF-α) and IL-1α secretion from hepatocytes, which were confirmed to contribute to the observed apoptosis since antibodies against these cytokines blocked the effects.
Dandelion (root) hot water extract has been noted in vitro to have anticancer properties at the level of the pancreatic cancer cell (BxPC-2 and PANC-1) by inducing autophagy secondary to loss of mitochondrial membrane potential; the same concentration of extract did not appear to have this function in noncancerous fibroblasts.
One study has found that the hot water extract of dandelion leaves, but not roots nor flowers, reduced the invasiveness of LNCaP prostatic cancer cells associated with less secretion of the matrix metalloproteinases MMP2 and MMP9, which help digest the surroundings of the tumor and may lead to metastasis.
Despite dandelion's use in the country of Jordan as a fertility enhancers, the hot water extract of dandelion given at two doses (1.065 and 2.13g/kg) to male rats over the course of sixty days in fact reduced fertility (from a reference 100% in control to 55.5-66.6%) associated with reduced sperm count and impaired sperm morphology. Serum testosterone appeared to also be reduced in accordance with abnormalities in testicular histology.
The above dose did not appear to have any overt teratogenic effects, and the estimated vegetable equivalent for this dose (see toxicology section for calculations) is 7.7g/kg fresh weight of dandelion.
Higher than normal doses of dandelion extract impair male fertility in rats due to testicular damage; the effect of recommended doses is not known.
When looking at the hot water extract, studies using doses claimed to be one tenth (2.13g/kg) and one twentieth (1.065g/kg) the supposed oral LD50 of 21.3g/kg in rats have found impairment to male fertility; the lower dose being around 2.5-5 times higher than the higher dosage used for antioxidant effects (400mg/kg of the hot water extract). Assuming no major interspecies differences, this translates into an estimated minimum toxic dose of around 170mg/kg in a human.
170mg/kg refers to the dry weight of the hot water extract, which is approximately 17% the weight of the plant's dry weight yeilding a minimum toxic dose of dry plant as 1g/kg. Assuming a water content of 87% the minimum weight of the actual plant to cause fertility issues in men would be 7.7g/kg bodyweight.
Other studies assessing the oral LD50 have found no acute toxicitiy associated with 10g/kg where intraperitoneal injections of 4g/kg were tolerated in both rats and mice whereas in mice an LD50 has been noted with intraperitoneal injection of 28.8g/kg of the herb and 36.8g/kg of the root.
The known LD50 of dandelion in rodents appears to be much higher than a human can expect to consume even with excessive ingestion of the vegetable, although the lowest dose associated with side-effects (while still higher than the recommended dose) could potentially be consumed with a high dietary intake of dandelion or high usage of dandelion supplements.
Dandelion is a plant of which it is possible to be allergic to, and it is advised people avoid supplementation or ingestion if there is a known allergic to honey, chamomile, chrysanthemums, yarrow, feverfew, and with some caution extended to other allergenic plants of the Asteraceae family such as ragweed, sunflower, and daisies. The most common form of allergy from dandelion is contact dermatitis and patch tests are available for assessment.
It is possible to be allergic to dandelion in which case supplementation should be avoided at all costs, and there may be some cross-allergenicity with other herbs in the same plant family.
There is a case report of a women with a history of type II diabetes on insulin therapy who experienced hypoglycemia two weeks after using dandelion in the form of a salad, and while causation was not placed on dandelion there was no recurring hypoglycemia after dandelion ingestion ceased.
- Greenlee H1, et al. A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. (2007)
- Verhoeven KJ1, Biere A. Geographic parthenogenesis and plant-enemy interactions in the common dandelion. BMC Evol Biol. (2013)
- van Dijk PJ. Ecological and evolutionary opportunities of apomixis: insights from Taraxacum and Chondrilla. Philos Trans R Soc Lond B Biol Sci. (2003)
- Sweeney B1, et al. Evidence-based systematic review of dandelion (Taraxacum officinale) by natural standard research collaboration. J Herb Pharmacother. (2005)
- Zhao L1, et al. Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GC/TOF MS. Evid Based Complement Alternat Med. (2013)
- Lee MH1, et al. The aerial part of Taraxacum coreanum extract has an anti-inflammatory effect on peritoneal macrophages in vitro and increases survival in a mouse model of septic shock. J Ethnopharmacol. (2013)
- Lee BR1, Lee JH, An HJ. Effects of Taraxacum officinale on fatigue and immunological parameters in mice. Molecules. (2012)
- Zgrajka W1, et al. Kynurenic acid content in anti-rheumatic herbs. Ann Agric Environ Med. (2013)
- Guarrera PM1, Savo V. Perceived health properties of wild and cultivated food plants in local and popular traditions of Italy: A review. J Ethnopharmacol. (2013)
- Kim YH1, et al. Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide. Arch Pharm Res. (2011)
- Warashina T1, Umehara K, Miyase T. Constituents from the roots of Taraxacum platycarpum and their effect on proliferation of human skin fibroblasts. Chem Pharm Bull (Tokyo). (2012)
- Mahesh A1, et al. Hepatocurative potential of sesquiterpene lactones of Taraxacum officinale on carbon tetrachloride induced liver toxicity in mice. Acta Biol Hung. (2010)
- Jovanović M1, et al. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-allergic chronic inflammatory skin diseases. Contact Dermatitis. (2004)
- Paulsen E1, Otkjaer A, Andersen KE. Sesquiterpene lactone dermatitis in the young: is atopy a risk factor. Contact Dermatitis. (2008)
- Kashiwada Y1, et al. Sesquiterpene glucosides from anti-leukotriene B4 release fraction of Taraxacum officinale. J Asian Nat Prod Res. (2001)
- Lee H-PD, Eichmeier LS, Piatak DM. Mass spectral study of ring E of taraxasterol and compounds with similar ring substitution. Org Mass Spectrom. (1985)
- Xiong H1, et al. Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages. J Ethnopharmacol. (2014)
- Domínguez XA, et al. Epi-friedelinol and taraxasterol acetate from Eupatorium azureum. Phytochemistry. (1973)
- Domínguez XA, et al. Taraxasterol from Stevia berlandieri and Cirsium texanum. Phytochemistry. (1974)
- Satyanarayana T, Devi K, Mathews AA. Taraxasterol and other triterpenoids in Capparis sepiaria leaves. J Pharmaceut Res Health Care. (2009)
- Dutta CP, Ray LPK, Roy DN. Taraxasterol and its derivatives from Cirsium arvense. Phytochemistry. (1972)
- Jamshieed S1, et al. Difference in in vitro response and esculin content in two populations of Taraxacum officinale Weber. Physiol Mol Biol Plants. (2010)
- Park CM1, et al. TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators. Food Chem Toxicol. (2010)
- Park CM1, Cho CW2, Song YS3. TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFκB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells. Food Chem Toxicol. (2014)
- Astafieva AA1, et al. Discovery of novel antimicrobial peptides with unusual cysteine motifs in dandelion Taraxacum officinale Wigg. flowers. Peptides. (2012)
- Astafieva AA1, et al. A novel cysteine-rich antifungal peptide ToAMP4 from Taraxacum officinale Wigg. flowers. Plant Physiol Biochem. (2013)
- Schütz K1, et al. Separation and quantification of inulin in selected artichoke (Cynara scolymus L.) cultivars and dandelion (Taraxacum officinale WEB. ex WIGG.) roots by high-performance anion exchange chromatography with pulsed amperometric detection. Biomed Chromatogr. (2006)
- Trojanová I1, et al. The bifidogenic effect of Taraxacum officinale root. Fitoterapia. (2004)
- Gorenjak AH1, Koležnik UR, Cencič A. Nitrate content in dandelion (Taraxacum officinale) and lettuce (Lactuca sativa) from organic and conventional origin: intake assessment. Food Addit Contam Part B Surveill. (2012)
- Nitrate in vegetables - Scientific Opinion of the Panel on Contaminants in the Food chain.
- Park CM1, et al. Taraxacum officinale Weber extracts inhibit LPS-induced oxidative stress and nitric oxide production via the NF-κB modulation in RAW 264.7 cells. J Ethnopharmacol. (2011)
- Hudec J1, et al. Antioxidant capacity changes and phenolic profile of Echinacea purpurea, nettle (Urtica dioica L.), and dandelion (Taraxacum officinale) after application of polyamine and phenolic biosynthesis regulators. J Agric Food Chem. (2007)
- Hu C1, Kitts DD. Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro. Phytomedicine. (2005)
- Davaatseren M1, et al. Taraxacum official (dandelion) leaf extract alleviates high-fat diet-induced nonalcoholic fatty liver. Food Chem Toxicol. (2013)
- González-Castejón M1, et al. Reduction of adipogenesis and lipid accumulation by Taraxacum officinale (Dandelion) extracts in 3T3L1 adipocytes: an in vitro study. Phytother Res. (2014)
- Hu C1, Kitts DD. Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Mol Cell Biochem. (2004)
- Kenny O1, et al. 4-hydroxyphenylacetic acid derivatives of inositol from dandelion (Taraxacum officinale) root characterised using LC-SPE-NMR and LC-MS techniques. Phytochemistry. (2014)
- Hook I, McGee A, Henman M. Evaluation of Dandelion for Diuretic Activity and Variation in Potassium Content. Pharm Biol. (1993)
- Clare BA1, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. (2009)
- Malizia D1, et al. Common plants as alternative analytical tools to monitor heavy metals in soil. Chem Cent J. (2012)
- Han H1, et al. Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. BMC Complement Altern Med. (2011)
- He W1, et al. Anti-influenza virus effect of aqueous extracts from dandelion. Virol J. (2011)
- Tahtamouni LH1, et al. Dandelion (Taraxacum officinale) decreases male rat fertility in vivo. J Ethnopharmacol. (2011)
- Kim H-Y, et al. Protective effect of HV-P411, an herbal mixture, on carbon tetrachloride-induced liver fibrosis. Food Chem. (2011)
- Kang JW1, et al. Protective effects of HV-P411 complex against D-galactosamine-induced hepatotoxicity in rats. Am J Chin Med. (2012)
- Maliakal PP1, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol. (2001)
- Zhu M1, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci. (1999)
- Li YC1, et al. Antidepressant effects of the water extract from Taraxacum officinale leaves and roots in mice. Pharm Biol. (2014)
- Zhang J1, et al. Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo. Nutr Res Pract. (2008)
- Modaresi M1, Resalatpour N. The Effect of Taraxacum officinale Hydroalcoholic Extract on Blood Cells in Mice. Adv Hematol. (2012)
- Choi UK1, et al. Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits. Int J Mol Sci. (2010)
- Onal S1, et al. Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol. (2005)
- Higuchi N1, et al. Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease. Exp Ther Med. (2011)
- Kim DI1, Kim KS2. Walnut extract exhibits anti-fatigue action via improvement of exercise tolerance in mice. Lab Anim Res. (2013)
- Slattery DA1, Cryan JF. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc. (2012)
- Jinchun Z1, Jie C. The effects of Taraxacum officinale extracts (TOE) supplementation on physical fatigue in mice. Afr J Tradit Complement Altern Med. (2011)
- Xu Y, et al. Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis. Exp Ther Med. (2014)
- Piao T, et al. Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes. Eur J Pharmacol. (2015)
- Stratz C, et al. Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes. Int Immunopharmacol. (2014)
- Kang BJ, et al. Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee. Biomol Ther (Seoul). (2014)
- Jeon HJ1, et al. Anti-inflammatory activity of Taraxacum officinale. J Ethnopharmacol. (2008)
- Koh YJ1, et al. Anti-inflammatory effect of Taraxacum officinale leaves on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells. J Med Food. (2010)
- Park CM1, et al. Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW 264.7 cells. Eur J Pharmacol. (2011)
- Liu J1, et al. Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. J Ethnopharmacol. (2013)
- Liu L1, et al. Taraxacum officinale protects against lipopolysaccharide-induced acute lung injury in mice. J Ethnopharmacol. (2010)
- San Z1, et al. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. Int Immunopharmacol. (2014)
- Jin YR1, et al. The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents. Neurogastroenterol Motil. (2011)
- Gulfraz M1, et al. Effect of leaf extracts of Taraxacum officinale on CCl4 induced Hepatotoxicity in rats, in vivo study. Pak J Pharm Sci. (2014)
- Domitrović R1, et al. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. J Ethnopharmacol. (2010)
- Colle D1, et al. Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice. J Med Food. (2012)
- You Y1, et al. In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. Food Chem Toxicol. (2010)
- Seo SW1, et al. Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats. World J Gastroenterol. (2005)
- Rácz-Kotilla E, Rácz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med. (1974)
- Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers.
- Sigstedt SC1, et al. Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol. (2008)
- Koo HN1, et al. Taraxacum officinale induces cytotoxicity through TNF-alpha and IL-1alpha secretion in Hep G2 cells. Life Sci. (2004)
- Ovadje P1, et al. Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells. Pancreas. (2012)
- Lovell CR1, Rowan M. Dandelion dermatitis. Contact Dermatitis. (1991)
- Goksu E1, et al. First report of hypoglycemia secondary to dandelion (Taraxacum officinale) ingestion. Am J Emerg Med. (2010)