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Rauwolscine

Rauwolscine is a molecule which is very similar in structure to yohimbine, and probably similar in its effects as well; may be more potent, but limited evidence exists.

Our evidence-based analysis on rauwolscine features 4 unique references to scientific papers.

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Research Breakdown on Rauwolscine


1Fat-Burning Potential

Rauwolscine, or {3H}Rauwolscine, is a potent and selective antagonist of alpha-2 adrenergic receptors.[1] This is the same mechanism by which yohimbine acts.

2Blood Vessel and Cardiac Health

{3H}Rauwolscine is less potent than yohimbine in protecting against adrenaline-induced blood pressure increases (both of which were less potent than corynanthine and more potent than 3-epi-alpha-yohimbine), this effect seems related to their affinity for the alpha-2 adrenoreceptor.[2]

3Serotonergic Effects

Like yohimbine, rauwolscine is an agonist of 5-HT1a/b receptors and induce serotonin-like effects. While yohimbine has more affinity for the receptor, rauwolscine has a lower IC50 value (meaning it can saturate more receptors at the same dose) and can be seen as slightly more potent in serotonergic activity.[3][4]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor|published=1998 Jan|authors=Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL|journal=Naunyn Schmiedebergs Arch Pharmacol]