Polygala Tenuifolia

    Last Updated: September 28, 2022

    Polygala tenuifolia is a root used in traditional Chinese medicine for its ability to improve memory and protect against cognitive ailments. Limited human evidence suggests Polygala tenuifolia cannot improve memory, but may improve spatial awareness and organization.

    Polygala Tenuifolia is most often used for .


    Polygala tenuifolia, also known as Yuan Zhi, is a root used in Traditional Chinese Medicine.

    It has traditionally been used for its protective effects on the brain.

    Preliminary animal evidence suggests that Polygala tenuifolia has an antidepressant effect in rats. Polygala tenuifolia may improve cognition, but more research is needed to confirm this effect.

    Rodent research suggests that Polygala tenuifolia is similar in mechanism and effectiveness to ketamine, which interacts with N-methyl-D-aspartic acid and its receptors. Rodent studies assessing Polygala tenuifolia’s anti-amnesiac and adaptogen-like properties suggest that the herb can increase the level of compounds responsible for brain growth, like nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).

    Though Polygala tenuifolia supplementation may slightly increase cognitive ability in elderly people, it has limited effect on healthy adults. Supplementing Polygala tenuifolia can improve spatial organization and recognition, but it does not improve short- or long-term memory formation, as measured by free or cued recall. Much more research is needed to determine if Polygala tenuifolia qualifies as a nootropic.

    What are other names for Polygala Tenuifolia

    Note that Polygala Tenuifolia is also known as:
    • Yuan Zhi
    • Chinese Senega
    Polygala Tenuifolia should not be confused with:

    Dosage information

    The only human studies on Polygala tenuifolia have used 100mg of an ethanolic extract called BT-11, three times a day, for a total daily dose of 300mg.

    A traditional Chinese medicine remedy suggests taking 3-9 g (dry weight) of Polygala tenuifolia root through a water decoction, like tea or soup, to reduce forgetfulness.

    Examine Database: Polygala Tenuifolia

    Research FeedRead all studies

    Examine Database References

    1. Memory - Lee JY, Kim KY, Shin KY, Won BY, Jung HY, Suh YHEffects of BT-11 on memory in healthy humansNeurosci Lett.(2009 Apr 24)
    2. Cognitive Decline - Shin KY, Lee JY, Won BY, Jung HY, Chang KA, Koppula S, Suh YHBT-11 is effective for enhancing cognitive functions in the elderly humansNeurosci Lett.(2009 Nov 13)