Oleamide is a derivative of Oleic Acid (major omega-9 fatty acid form Olive Oil) with a nitrogen group, and appears to be naturally associated with sleep; injections induce sleep and activate the same receptors as Marijuana.
Our evidence-based analysis features 61 unique references to scientific papers.
Follow this Page for updates
Table of Contents:
- 1 Sources and Summary
- 2 Pharmacology
- 3.1 Mechanisms
- 3.2 Serotoninergic Neurotransmission
- 3.3 Glutaminergic Neurotransmission
- 3.4 GABAergic Neurotransmission
- 3.5 Glycinergic Neurotransmission
- 3.6 Cholinergic Neurotransmission
- 3.7 Sedation and Sleep
- 3.8 Memory and Learning
- 3.9 Food Intake
- 3.10 Libido and Aphrodisia
- 3.11 Anxiety
- 3.12 Depression
- 3.13 Pain
- 3.14 Neuroinflammation and Cannabinoids
- 3.15 Withdrawal
- 4 Cardiovascular Health
Oleamide (cis-9,10-octadecenoamide) is a molecule produce endogenously from Oleic Acid (the omega-9 fatty acid known to be associated mostly with Olive oil) and first isolated in human serum in 1989. Oleamide appears to accumulate in the brain and cerebrospinal fluid (CSF) during sleep deprivation, with extension of sleep deprivation 6 hours beyond normal sleep time causing a 4-6 fold increase in Oleamide content of CSF, and is likely to be relevant to all species investigated as Oleamide is common across species.
Beyond the endogenous synthesis of oleamide, it has been detected in:
Oleamide is a naturally occurring metabolite of Oleic acid which appears to be involved as a neuropeptide related to sleep. It may also be found in a traditional chinese medicine involved in sedation
Oleamide tends to refer to cis-oleamide and the trans-isomer appears to be unable to mediate numerous biological effects on gap junctions, serotonin receptors (5-HT2A and 5-HT2C), and GABAA receptors. There is limited efficacy on the 5-HT1A receptor, with about half the efficacy as the cis isomer and injections of the trans isomer appear to be around half as effective as the cis isomer.
Oleamide has been noted to be synthesized in brain slices incubated with both oleic acid and ammonia which is mediated by enzymes as boiling the brain slices (denaturing enzymes) abolished the synthesis.
Oleamide can be degraded into Oleic acid via the membrane enzyme Fatty acid amide hydrolase (FAAH), the same enzyme that metabolites anandamide (arachidonoyl ethanolamide) and bioactives in marijuana. Interestingly, inhibiting this enzyme has been noted to inhibit synthesis of oleamide (mouse N18TG2 cells) although the exact biosynthesis route is note yet determined. What appears to be known is that oleic acid is converted into Oleoyl-CoA and then N-Oleoylglycine where oxidative cleavage of N-Oleoylglycine by the enzyme peptidylglycine α−amidating monooxygenase (PAM) creates oleamide. It should be noted that the intermediate N-Oleoylglycine appears to be biologically active as well.
Oleamide appears to be synthesized in the human body (due to circulating levels detected) from oleic acid and ammonia. Although the biosynthetic enzymes are not fully characterized yet, oleamide is degraded by the FAAH enzyme due to being a fatty acid amide
4 hours of incubation at 37°C does not appear to structurally damage oleamide, although introduction of bile acids is able to accelerate metabolism and destroy 95% of oleamide under the same conditions.
Basal serum levels of Oleamide in a human appear to be approximately 31.7μg/ml (110μM) or lower (9.9 μg/L (35nM) and 16 μg/L (56nM)) and in mouse neuroblastoma cells concentrations appear to be 1.5 μg/109 cells.
Anandamide is known to activate the TRPV1 receptor but the interaction with oleamide is unknown; administration of a TRPV1 antagonist (Capsazepine) does not appear to alter behavioural effects of oleamide.
May be able to activate TRPV1 receptors, practical significance of this is unknown
Oleamide has been found to inhibit dye transfer between isolated glial cells expressing α1connexin and cells expressing β1connexin with a maximum efficacy at 50μM, but does not appear to inhibit Ca2+ wave propogation; the latter was successfully blocked by 18β-glycyrrhetinic acid (bioactive of licorice), a classical gap junction inhibitor. It is unsure if these effects occur in the body due to the higher concentration being required, but if they do occur then they may underlie very slight anti-epileptic effects.
May be a gap junction inhibitor, albeit at quite high doses. Practical significance of this information is unknown
Oleamide appears to interact with sodium channels on neurons (high voltage sodium channels being important for neuronal action potentials), as it can block a veratridine induced depolarization independent of influencing potassium signalling (IC50 of 13.93μM) and was able to reduce the veratridine induced spike in calcium influx without affecting basal concentrations. Inhibitory effects have also been noted against batrachotoxinin A (on tetradotoxin sensitive channels) and, due to increasing dissociation without influencing the association constant, it is thought that oleamide allosterically modulates the channel. The concentration range it works at (3.2-64μM) at the same concentrations it is active on GABA and Glycine receptors, suggesting that it may contribute to the depressant effects.
Cis-oleamide has also been noted to suppress sustained repetitive firing with an EC50 of 4.1μM, and this is thought to be related to the inhibition of sodium channels.
Appears to be a biologically relevant sodium channel inhibitor
On 5-HT2A receptors, 10-300nM of Oleamide is able to potentiate serotonin-induced recpetor signalling as assessed by Phosphoinositide Hydrolysis, with 100nM causing a 228% enhanced signalling effect without influencing signalling per se. This potentiation on 5-HT2A (165-170% at 100-1000nM in another study) has been replicated and has been shown to extend to 5-HT1A and 5-HT2C (360-570% at 100-1000nM) with concentrations as low as 1nM having a visible effect with no significant influence on 5-HT3 receptors. Oleamide does not affect ligand binding of serotonin to the 5-HT receptors.
The above potentiating effect does not appear to be due to modifying the EC50 value of serotonin (which is unmodified), but appears to be through enhancing post-receptor signalling independent of serotonin binding efficacy. Additionally, all of these effects appear to be critically dependent on the omega-9 desaturated bond as modifying this omega-9 fatty amide into an omega-6 reverses its potentiating properties while saturating the bond abolishes it.
Appears to interact highly with serotonin receptors, augmenting the signalling of serotonin agonists through the 2X receptor subsets. The potency of the above is fairly remarkable, and occurs at very low concentrations with high efficacy. Oleamide is likely a serotonergic synergist
On 5-HT7 receptors, Oleamide can act as a direct agonist with an EC50 value of 4.2nM in the absence of serotonin. Serotonin itself had an EC50 value of 52nM, and it appeared that Oleamide (in the presence of serotonin) acted as a competitive inhibitor on the 5-HT7 receptor (specifically, an insurmountable antagonist). The effects of both serotonin and Oleamide on the receptor were inhibited by ketanserin by about 65, and Oleamide was determined to not bind to the classical binding site on the 5-HT7 receptors.
In regards to other receptor subtypes, there may be competitive antagonistic properties or no significant influence
Pretreatment with fluxetine or fenfluramine (serotonin reuptake inhibitors) is able to inhibit the increase in sleep observed with Oleamide as did the 5-HT1A agonists Busiprone and 8-OH-DPAT, despite the latter class not inherently influencing sleep. The 5-HT1A antagonist WAY100635 did not augment Oleamide induced sleep, but it prevented other agents from reducing the induction of sleep by Oleamide.
SSRIs and 5-HT1A agonists may abolish the effects of Oleamide in regards to sleep
Oleamide does not appear to have much affinity towards glutaminergic receptors including NMDA, AMPA, and metabotropic glutaminergic receptors.
No known interactions with glutaminergic receptors or transmission
Oleamide is known to enhance GABAA dependent currents with efficacy as low as 3.2μM and in a reversible manner. This positive modulation is only seen with the cis-oleamide isomer as the trans form is inactive, and GABAA receptors containing β1 subunits (which may be insensitive to some depressants) are still positively modulated by oleamide.
Oleamide does not significantly affect ligand binding to the GABAA receptors, nor is GABA uptake into synaptosomes affected.
Oleamide appears to enhance GABA signalling through the GABAA receptors, without itself being a ligand or affecting ligand binding. The exact mechanisms underlying this enhanced signalling are not known
Glycine receptors appear to be positively influenced by oleamide in the same way GABA receptors are, with a maximal enhancement to 171% of baseline and an EC50 of 22.12μM, with the EC50 of glycine acting on this receptor being reduced from 322.2μM to 239.4μM.
Oleamide appears to enhance glycinergic signalling
Oleamide has failed to show significant affinity for muscarinic cholinergic receptors.
Has the potential to enhance acetylcholine synthesis, although this has not been demonstrated in vivo and oleamide does not appear to interact with acetylcholine receptors
Mechanistically, Oleamide does not appear to have much affinity for GABAA receptors although it has been demonstrated to potentiate signalling via the GABAA receptor in vitro, which also appears to apply to oleic acid itself (contested). Oleamide does not alter binding of GABA to the GABAA benzodiazepine receptor at concentrations up to 50mM.
May not have significant interactions with GABA or Benzodiazepine receptors directly, but may potentiate signalling of the receptors via other agents. Oleamide is likely a GABA synergist
Oleamide is known to, after intravenous injection, induce a dose-dependent induction of sleep with concomitant decreases in wakefulness and sleep latency (time required to fall asleep) and dose-dependent decreases in body temperature. Injections of 25, 50, and 100mg/kg Oleamide reduce sleep latency by 13, 24, and 33% repectively while 200mg/kg had a 28% reduction (dose dependence not present at this dose).
In an open-field test of locomotoin, the ED50 (dose causing half of the observed effect) of reducing locomotion appeared to be an injection of 17+/-1.5mg/kg with another study noting an ED50 of 10-19mg/kg. Other studies have noted dose-dependent decreases in locomotor activity at injection doses as low as 2.5mg/kg, and following injections the reduction in locomotion appears to last up to 60 minutes (most efficacy at 30 minutes) and is normalized 2 hours after injection.
This locomotion induced by Oleamide is further reduced 70% with pretreatment of a 5HT1A antagonist while being partly reversed (77%) by a D2 antagonist.
Oleamide injections appear to cause dose-dependent reductions in the time required to fall asleep and reductions in locomotion in research animals with high reliability
In regards to REM sleep, injections of 25-200mg/kg Oleamide in rats failed to significantly influence REM sleep and lower doses (2.5-20mg/kg) also fail to increase REM despite reducing sleep latency. One study has noted an increase in REM sleep with single and 15 days injections of oleamide (25mcg) intracerebrally, but is the least practical research method used (when assessing how oral supplementation would work).
Although it has at times been implicated in improving REM sleep, this does not seem to be reliably seen
Mechanistically, activation of the CB1 receptor is known to impair long-term potentiation (LTP) in the hippocampus and while 32µM of oleamide is unable to per se affect basal LTP it has been noted to attenuate higher than average LTP.
Via activation of the CB1 receptors, oleamide can suppress long term potentiation
5mg/kg injections of oleamide to mice prior to a spatial learning task (Y-maze) has noted an improvement in performance, which was not seen with 10mg/kg.
In a passive avoidance test in rats, 30-50mg/kg oleamide injections has been noted to facilitate memory extinction with no apparent effect on memory recall 24 hours after testing. This test noted that the observed effects were also known to occur with cannabinoids including ananadamide, and since the effects of ananadamide are blocked by CB1 agonists it is thought that this receptor mediates the possible amnesiac effects of oleamide. Working memory has also been found to be impaired with oleamide (as well as ananadamide), which is exacerbated in situations where oleamide degradation is reduced.
Oleamide has been implicated in both an improvement in memory (spatial learning) as well as amnesiac effects (memory recollection and/or increasing extinction)
0.16-0.32% of the diet for four weeks (mice; totalling 14-16mg daily) as oleamide is able to slightly attenuate the amnesiac effects of scopolamine.
Against a cholinergic toxin, oleamide has shown a small anti-amnesiac effect
Injections of oleamide to rats appear to cause an increase in food consumption over the course of three hours.
Despite the endocannabinoid anandamide causing alterations in sexual behaviour, oleamide does not appear to induce any observable alterations in rats.
In a rat social interaction test and elevated maze plus, 5mg/kg injections of Oleamide that were too low to influence locomotion were able to exert anxiolytic effects.
Administration of 10mg/kg oleamide to male mice appears to exert anti-depressant effects in a forced swim test, with 5mg/kg being ineffective and neither dose affecting female mice.
Some analgesic effects have been noted to occur with Oleamide, but 10-75mg/kg appeared to be unreliable and not overly potent in a preliminary rat hot-plate test although it showed promise in a tail-flick test. These moderate efficacy pain-killing effects lasted up to 60 minutes and elsewhere 50mg/kg (but not 30mg/kg) has been noted to increase tail-flick latency for an hour and dissipated thereafter. This latter study confirmed a failure to provide analgesic effects to a hot-plate test.
In murine microglia cells (neural cells), Oleamide is able to suppress LPS-induced activation (assessed by nitric oxide and PGE2) at 10μM and almost fully abolishing microglia activation at 100μM. This, as well as abolishing Reactive Oxygen Species (ROS) production in the cells, was due to inhibition of PI3K/Akt and NF-kB transactivation which were both downstream of the Cannabinoid 2 receptor (CB2); blocking the CB2 receptor abolishes the anti-inflammatory effects of Oleamide. Oleic acid itself also has anti-inflammatory effects, but weaker and not mediated via the CB2 receptor.
Oleamide appears to exert anti-neuroinflammatory effects via acting upon the Cannabinoid 2 receptor (CB2), but the concentration requires is quite high
Oleamide has been noted to prevent binding of agonists (CP55,940 and rimonabant) to the CB1 receptor with no significant influence on CB2 binding affinity. There is some activation of the CB1 receptor seen with oleamide, but this is also abolished with coincubation of rimonabant. It has, however, been argued that these effects are not relevant due to high concentrations used in vitro (10μM) which may not be acheived following oral ingestion.
Oleamide appears to interact with the CB1 receptor, the main receptor that is thought to mediate the psychoactive effects of marijuana
Oleamide has been investigated for its potentially addictive properties as it is known to enhance signalling at the GABAA receptors, which is the pharmacological effect of benzodiazepine drugs (via the benzodiazepine binding site, located on GABAA receptors).
A test administering Oleamide for 10 days (30mg/kg twice daily to rats) and then abruptly stopping treatment failed to find evidence of withdrawal, as withdrawal symptoms were not different between Oleamide condition and control. Coadministration of CB1 antagonists seems to cause withdrawal symptoms with the aforementioned dosing regiment, but they are to a lesser degree than opiates and anandamide.
Administration of oleamide for 15 days followed by abrupt cessation does not appear to negatively impact sleep when compared to control rats, although the enhancement of REM sleep seen with oleamide treatment was lost.
There is currently no evidence to suggest that oleamide has addictive potential, but due to one of its mechanisms of actions (enhancing GABAA signalling) it is still theoretically possible for oleamide to be somewhat addictive like a weak benzodiazepine. Longer duration studies would be needed, and perhaps higher dosages as well
Acutely, injections of Oleamide that induce sleep and hypothermia fail to significantly affect blood pressure and heart rate
Oleamide is able to induce concentration and endothelium-dependent relaxation in arteries (0.01-10μM) with an EC50 of 350+/-260nM, with oleic acid and other FAAH metabolites not being involved in the observed vasorelaxation. These observed effects are mediated in part by the Cannabinoid Receptor 1 (CB1) and the non-CB1/CB2 antagonist O-1918 (Cannabinoid antagonist targeting other receptors) as well as TRPV1 (antagonist partially inhibited the effects of Oleamide) whereas elsewhere endothelial cells precontracted with an α-adrenergic agonist also noted vasorelaxation (EC50 of 1.2μM) but by mechanisms not related to the CB1 receptor and instead partially reliant on TRPV1 and nitric oxide.
Oleamide appears to have vasorelaxing properties, although it is uncertain how this practically affects the body. In looking at the potency in vitro, it is probably relevant to oral supplementation
- Mueller GP, Driscoll WJ. Biosynthesis of oleamide. Vitam Horm. (2009)
- Basile AS, Hanus L, Mendelson WB. Characterization of the hypnotic properties of oleamide. Neuroreport. (1999)
- Cravatt BF, et al. Chemical characterization of a family of brain lipids that induce sleep. Science. (1995)
- Heo HJ, et al. Effects of oleamide on choline acetyltransferase and cognitive activities. Biosci Biotechnol Biochem. (2003)
- Hiley CR, Hoi PM. Oleamide: a fatty acid amide signaling molecule in the cardiovascular system. Cardiovasc Drug Rev. (2007)
- Guan X, et al. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol. (1997)
- Huidobro-Toro JP, Harris RA. Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors. Proc Natl Acad Sci U S A. (1996)
- Boger DL, et al. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proc Natl Acad Sci U S A. (1998)
- Stereoselective modulatory actions of oleamide on GABAA receptors and voltage-gated Na+ channels in vitro: a putative endogenous ligand for depressant drug sites in CNS.
- Sugiura T, et al. Enzymatic synthesis of oleamide (cis-9, 10-octadecenoamide), an endogenous sleep-inducing lipid, by rat brain microsomes. Biochem Mol Biol Int. (1996)
- McKinney MK, Cravatt BF. Structure and function of fatty acid amide hydrolase. Annu Rev Biochem. (2005)
- Koutek B, et al. Inhibitors of arachidonoyl ethanolamide hydrolysis. J Biol Chem. (1994)
- De Petrocellis L, et al. Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem Biophys Res Commun. (1997)
- Bisogno T, et al. The sleep inducing factor oleamide is produced by mouse neuroblastoma cells. Biochem Biophys Res Commun. (1997)
- Merkler DJ, et al. Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. Biochemistry. (2004)
- Chaturvedi S, et al. In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. Prostaglandins Other Lipid Mediat. (2006)
- Cooper I, Lord T, Tice PA. Hydrolysis studies on oleamide in simulated gastrointestinal fluids. Food Addit Contam. (1995)
- Arafat ES, et al. Identification of fatty acid amides in human plasma. Life Sci. (1989)
- Hanus LO, et al. A gas chromatographic-mass spectral assay for the quantitative determination of oleamide in biological fluids. Anal Biochem. (1999)
- Driscoll WJ, et al. Differential regulation of peptide alpha-amidation by dexamethasone and disulfiram. Mol Pharmacol. (1999)
- Zygmunt PM, et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. (1999)
- Fedorova I, et al. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. J Pharmacol Exp Ther. (2001)
- Dougalis A, Lees G, Ganellin CR. The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. Neuropharmacology. (2004)
- Lees G. Molecular mechanisms of anaesthesia: light at the end of the channel. Br J Anaesth. (1998)
- Nicholson RA, et al. Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. Anesthesiology. (2001)
- Effects of Oleamide on Tetrodotoxin-sensitive Sodium Channels Investigated.
- Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide.
- Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide.
- Yang JY, et al. The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. Naunyn Schmiedebergs Arch Pharmacol. (2003)
- The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro.
- Lees G, et al. Modulation of GABA(A) receptors and inhibitory synaptic currents by the endogenous CNS sleep regulator cis-9,10-octadecenoamide (cOA). Br J Pharmacol. (1998)
- Belelli D, et al. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci U S A. (1997)
- Krasowski MD, Harrison NL. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol. (2000)
- Oda Y. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int. (1999)
- Benishin CG, Carroll PT. Acetylation of choline and homocholine by membrane-bound choline-O-acetyltransferase in mouse forebrain nerve endings. J Neurochem. (1981)
- Yost CS, et al. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. Anesth Analg. (1998)
- Effect of Oleamide on Sleep and Its Relationship to Blood Pressure, Body Temperature, and Locomotor Activity in Rats.
- Herrera-Solís A, Vásquez KG, Prospéro-García O. Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats. Pharmacol Biochem Behav. (2010)
- Nowicky AV, Teyler TJ, Vardaris RM. The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro. Brain Res Bull. (1987)
- Paton GS, Pertwee RG, Davies SN. Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice. Neuropharmacology. (1998)
- Lees G, Dougalis A. Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro. Brain Res. (2004)
- Akanmu MA, Adeosun SO, Ilesanmi OR. Neuropharmacological effects of oleamide in male and female mice. Behav Brain Res. (2007)
- Murillo-Rodríguez E, et al. Oleamide modulates memory in rats. Neurosci Lett. (2001)
- Piomelli D, et al. The endocannabinoid system as a target for therapeutic drugs. Trends Pharmacol Sci. (2000)
- Murillo-Rodríguez E, et al. Anandamide modulates sleep and memory in rats. Brain Res. (1998)
- Murillo-Rodríguez E, et al. Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor. Neuroreport. (2001)
- Varvel SA, et al. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. J Pharmacol Exp Ther. (2006)
- Martínez-González D, et al. Oleamide and anandamide effects on food intake and sexual behavior of rats. Neurosci Lett. (2004)
- A Critical Analysis of the Experimental Evaluation of Nociceptive Reactions in Animals.
- Pastoriza LN, Morrow TJ, Casey KL. Medial frontal cortex lesions selectively attenuate the hot plate response: possible nocifensive apraxia in the rat. Pain. (1996)
- Oh YT, et al. Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells. Neurosci Lett. (2010)
- Fernández-Ruiz J, et al. Cannabinoid CB2 receptor: a new target for controlling neural cell survival. Trends Pharmacol Sci. (2007)
- Ashton JC, Glass M. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Curr Neuropharmacol. (2007)
- Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.
- Oleamide: a member of the endocannabinoid family?.
- Sigel E, Lüscher BP. A closer look at the high affinity benzodiazepine binding site on GABAA receptors. Curr Top Med Chem. (2011)
- Sigel E. Mapping of the benzodiazepine recognition site on GABA(A) receptors. Curr Top Med Chem. (2002)
- Matthes HW, et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature. (1996)
- Costa B, Giagnoni G, Colleoni M. Precipitated and spontaneous withdrawal in rats tolerant to anandamide. Psychopharmacology (Berl). (2000)
- Sudhahar V, Shaw S, Imig JD. Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. Eur J Pharmacol. (2009)
- Hoi PM, Hiley CR. Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br J Pharmacol. (2006)
Cite this page
"Oleamide," Examine.com, published on 19 July 2013, last updated on 14 June 2018, http://examine.com/supplements/oleamide/