What are NMN’s main benefits?
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NMN is taken as a supplement to increase levels of the coenzyme NAD+. It is unknown whether NMN will have the same therapeutic effects in humans as seen in rodent models, but emerging evidence is promising.[1][2]
So far, most randomized controlled trials in humans have focused on proving the safety of NMN supplements and their ability to increase blood NAD+ levels in different populations. Some clinical research has shown that NMN increases physical ability in aging populations,[3] improves cardiovascular disease biomarkers such as arterial stiffness,[4] and increases cellular NAD+/NADH levels.[1] Although these results have been promising, additional large-scale trials are needed to better understand the benefits in humans.
1.^Huang HA Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults.Front Aging.(2022)
2.^Alegre GFS, Pastore GMNAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health.Curr Nutr Rep.(2023-Jun-05)
3.^Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar VThe efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.Geroscience.(2023-Feb)
4.^Katayoshi T, Uehata S, Nakashima N, Nakajo T, Kitajima N, Kageyama M, Tsuji-Naito KNicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.Sci Rep.(2023-Feb-16)