Ku shen

Last Updated: November 18 2022

Sophora flavescens (Ku Shen) is a medicinal herb from China that appears to possess mostly anti-cancer properties. It may also inhibit the 5-Alpha Reductase enzyme and PDE5 potently, promoting hair growth and erectogenesis.

Ku shen is most often used for

What else is Ku shen known as?
Note that Ku shen is also known as:
  • Ku Shen
  • Kushen
  • Ku-Shen
  • Sophora Flavescens

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    References
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    4.^Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi TAntibacterial and antiandrogen flavonoids from Sophora flavescensJ Nat Prod.(1999 Dec)
    5.^Berghe WV, De Naeyer A, Dijsselbloem N, David JP, De Keukeleire D, Haegeman GAttenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. rootsEndocr Metab Immune Disord Drug Targets.(2011 Sep 1)
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    9.^Woo ER, Kwak JH, Kim HJ, Park HA new prenylated flavonol from the roots of Sophora flavescensJ Nat Prod.(1998 Dec)
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    33.^Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang GEffects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migrationCytotechnology.(2009 Apr)
    35.^Zhang J, Li Y, Chen X, Liu T, Chen Y, He W, Zhang Q, Liu SAutophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cellsOncol Rep.(2011 Jul)
    36.^Dai ZJ, Gao J, Ji ZZ, Wang XJ, Ren HT, Liu XX, Wu WY, Kang HF, Guan HTMatrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3J Ethnopharmacol.(2009 May 4)
    37.^Zhang S, Zhang Y, Zhuang Y, Wang J, Ye J, Zhang S, Wu J, Yu K, Han YMatrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt InactivationPLoS One.(2012)
    38.^Zhang JQ, Li YM, Liu T, He WT, Chen YT, Chen XH, Li X, Zhou WC, Yi JF, Ren ZJAntitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagyWorld J Gastroenterol.(2010 Sep 14)
    40.^Chen K, Hu Z, Wang T, Guo H, Ye ZInhibitory effect of matrine on the expression of PSA and AR in prostate cancer cell line LNCaPJ Huazhong Univ Sci Technolog Med Sci.(2008 Dec)
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    43.^Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, Cheng X, Qian R, Zhang XMatrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cellsEur J Pharmacol.(2007 Mar 22)
    44.^Liu XY, Fang H, Yang ZG, Wang XY, Ruan LM, Fang DR, Ding YG, Wang YN, Zhang Y, Jiang XL, Chen HCMatrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitroInt J Dermatol.(2008 May)
    45.^Chen CH, Lai JM, Chou TY, Chen CY, Su LJ, Lee YC, Cheng TS, Hong YR, Chou CK, Whang-Peng J, Wu YC, Huang CYVEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathwayPLoS One.(2009)
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    54.^Lin P, Zhang J, Rong Z, Han R, Xu S, Gao R, Ding Z, Wang J, Feng H, Cao SStudies on medicamentous inhibitory therapy for esophageal precancerous lesions--3- and 5-year inhibitory effects of antitumor-B, retinamide and riboflavinProc Chin Acad Med Sci Peking Union Med Coll.(1990)
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    56.^Sit DS, Gao G, Law FC, Li PCGas chromatography-mass spectrometry determination of matrine in human plasmaJ Chromatogr B Analyt Technol Biomed Life Sci.(2004 Sep 5)