Japanese raisin tree

•Last Updated: November 18 2022

Hovenia dulcis (Japanese Raisin Tree) is a source of dihydromyricetin (Ampelopsin) and has traditionally been used as an anti-alcohol herb and hangover cure. At least one human study has noted that, when taken before drinking, it can reduce circulating levels of alcohol.

dosage

Japanese raisin tree is most often used for

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Kamal Patel, MPH, MBA

Last Updated: November 18 2022

Dosage information
Research breakdown
References

What else is Japanese raisin tree known as?

Note that Japanese raisin tree is also known as:

Japanese Raisin Tree
Hovenia Dulcis

Dosage information

An ethanolic extract of 125mg/kg has been used in rats with efficacy, which translates to an estimated human dosage of:

1,400mg for a 150lb person
1,800mg for a 200lb person
2,300mg for a 250lb person

These are estimated human doses based on rat studies, and it is uncertain if they are the optimal dosage or not.

Research Breakdown

1

Source and Composition

1.1

Composition

2

Interactions with the Liver and Alcohol

2.1

Ethanol Metabolism

2.2

Protection

3

Immunology and Inflammation

4

Safety and Toxicology

4.1

General

References

1.^A palynotaxonomic study of the Korean Rhamnaceae.()

2.^Advances in Studies on Bioactivity of Hovenia dulcis.()

3.^Hyun TK, Eom SH, Yu CY, Roitsch THovenia dulcis--an Asian traditional herbPlanta Med.(2010 Jul)

4.^Xiang J, Zhu W, Li Z, Ling SEffect of juice and fermented vinegar from Hovenia dulcis peduncles on chronically alcohol-induced liver damage in miceFood Funct.(2012 Jun)

5.^Changes in Antioxidant Properties of Hovenia dulcis Thunb Vinegar during Fermentation Process.()

6.^Yoshikawa M, Murakami T, Ueda T, Yoshizumi S, Ninomiya K, Murakami N, Matsuda H, Saito M, Fujii W, Tanaka T, Yamahara JBioactive constituents of Chinese natural medicines. III. Absolute stereostructures of new dihydroflavonols, hovenitins I, II, and III, isolated from hoveniae semen seu fructus, the seed and fruit of Hovenia dulcis THUNB. (Rhamnaceae): inhibitory effect on alcohol-induced muscular relaxation and hepatoprotective activityYakugaku Zasshi.(1997 Feb)

7.^Yoshikawa M, Murakami T, Ueda T, Matsuda H, Yamahara J, Murakami NBioactive saponins and glycosides. IV. Four methyl-migrated 16,17-seco-dammarane triterpene gylcosides from Chinese natural medicine, hoveniae semen seu fructus, the seeds and fruit of Hovenia dulcis THUNB.: absolute stereostructures and inhibitory activity on histamine release of hovenidulciosides A1, A2, B1, and B2Chem Pharm Bull (Tokyo).(1996 Sep)

8.^Yoshikawa M, Ueda T, Muraoka O, Aoyama H, Matsuda H, Shimoda H, Yamahara J, Murakami NAbsolute stereostructures of hovenidulciosides A1 and A2, bioactive novel triterpene glycosides from hoveniae semen seu fructus, the seeds and fruit of Hovenia dulcis ThunbChem Pharm Bull (Tokyo).(1995 Mar)

9.^Effect of Water Extracts of Crude Drugs in Decreasing Blood Ethanol Concentrations in Rats.()

10.^Effect of extracts from Hovenia dulcis Thunb. alcohol concentration in rats and men administered alcohol.()

11.^Fang HL, Lin HY, Chan MC, Lin WL, Lin WCTreatment of chronic liver injuries in mice by oral administration of ethanolic extract of the fruit of Hovenia dulcisAm J Chin Med.(2007)

12.^Hase K, Ohsugi M, Xiong Q, Basnet P, Kadota S, Namba THepatoprotective effect of Hovenia dulcis THUNB. on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharideBiol Pharm Bull.(1997 Apr)

13.^Wang M, Zhu P, Jiang C, Ma L, Zhang Z, Zeng XPreliminary characterization, antioxidant activity in vitro and hepatoprotective effect on acute alcohol-induced liver injury in mice of polysaccharides from the peduncles of Hovenia dulcisFood Chem Toxicol.(2012 Sep)

14.^Du J, He D, Sun LN, Han T, Zhang H, Qin LP, Rahman KSemen Hoveniae extract protects against acute alcohol-induced liver injury in micePharm Biol.(2010 Aug)

Primary Use