Gou-teng

Last Updated: September 28 2022

Uncaria rhynchophylla (Gou-Teng or Chotoko) is an antiepileptic eastern medicine and major component of 'Yokukansan' for the treatment of agitation in elderly persons. It appears to be neuroprotective, anticonvulsive, and has antipsychotic properties like Aripiprazole.

Gou-teng is most often used for

Summary

Uncaria rhynchophylla (not to be confused with Uncaria Tomentosa) is a traditional chinese medicine and Japanese medicine that is used for the treatment of hypertension, convulsive disorders (epilepsy), and for various head ailments such as headache or dizziness. It contains a variety of alkaloid structures, most notably the one named after it (Rhynchophylline) and a potent drug-like alkaloid with the acronym of GME (Geissoschizine methyl ether). It is a component of the popular japanese medicinal formula known as Yokukansan, where it alongside glycyrrhiza uralensis (licorice) seem to mediate the neuroprotective effects.

Studies that use oral ingestion of the herb or isolated alkaloids are only in the animal phases of research at this point in time, but it appears that GME has antipsychotic properties very similar to Aripiprazole (pharmaceutical) on the serotonin and dopamine receptors. The influence on the serotonin receptors also confers some anxiety reducing properties, and can reduce social aggression (thought to be the reason why Yokukansan reduces agitation in elderly persons with dementia).

There is also a neuroprotective effect that is mostly based on preventing the brain's support cells (glial cells, which support the neurons) from activating in response to inflammation. This antiinflammatory effect in the brain appears to underlie anti-epileptic properties with oral ingestion of the herb.

Beyond that, there is potential for this herb to reduce blood pressure secondary to activating nitric oxide signalling but this has not yet been investigated in living systems.

What else is Gou-teng known as?
Note that Gou-teng is also known as:
  • Uncariae Uncis Cum Ramulus
  • Choto-ko
  • Choto-san
  • Pulvis Uncariae
  • Diao-teng-san
  • Gou-teng
  • Uncaria Rhynchophylla
Gou-teng should not be confused with:
  • Cat's Claw (Uncaria tomentosa or guianensis)
Dosage information

There is currently no evidence in humans to recommend an ideal human dose, but based on the rat studies conducted noting efficacy with the water extract at 250-1,000 mg/kg oral intake a preliminary guess at the dosages would be:

  • 2,700-11,000 mg for a 150lb person
  • 3,600-14,500 mg for a 200lb person
  • 4,500-18,000 mg for a 250lb person

The formulation known as Yokukansan (one serving is 20.5 grams) which is given to humans contains three grams of uncaria rhynchophylla, and this may be a prudent starting dose even if using it in isolation.

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References
1.^Hou WC, Lin RD, Chen CT, Lee MHMonoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophyllaJ Ethnopharmacol.(2005 Aug 22)
2.^Kang TH, Murakami Y, Matsumoto K, Takayama H, Kitajima M, Aimi N, Watanabe HRhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytesEur J Pharmacol.(2002 Nov 22)
3.^Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, Tomita N, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Ohizumi Y, Arai HUncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteinsJ Neurosci Res.(2006 Aug 1)
6.^Nishi A, Yamaguchi T, Sekiguchi K, Imamura S, Tabuchi M, Kanno H, Nakai Y, Hashimoto K, Ikarashi Y, Kase YGeissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansanNeuroscience.(2012 Apr 5)
7.^Cardoso CL, Castro-Gamboa I, Silva DH, Furlan M, Epifanio Rde A, Pinto Ada C, Moraes de Rezende C, Lima JA, Bolzani Vda SIndole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitorsJ Nat Prod.(2004 Nov)
12.^Shi JS, Yu JX, Chen XP, Xu RXPharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophyllineActa Pharmacol Sin.(2003 Feb)
15.^Kim KS, Pham TN, Jin CJ, Umeyama A, Shoji N, Hashimoto T, Lee JJ, Takei MUncarinic Acid C Isolated from Uncaria rhynchophylla Induces Differentiation of Th1-Promoting Dendritic Cells Through TLR4 SignalingBiomark Insights.(2011 Feb 28)
16.^Umeyama A, Yahisa Y, Okada M, Okayama E, Uda A, Shoji N, Lee JJ, Takei M, Hashimoto TTriterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarizationJ Nat Med.(2010 Oct)
19.^Sekiya N, Shimada Y, Shibahara N, Takagi S, Yokoyama K, Kasahara Y, Sakakibara I, Terasawa KInhibitory effects of Choto-san (Diao-teng-san), and hooks and stems of Uncaria sinensis on free radical-induced lysis of rat red blood cellsPhytomedicine.(2002 Oct)
22.^Chou CH, Gong CL, Chao CC, Lin CH, Kwan CY, Hsieh CL, Leung YMRhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channelsJ Nat Prod.(2009 May 22)
23.^Imamura S, Tabuchi M, Kushida H, Nishi A, Kanno H, Yamaguchi T, Sekiguchi K, Ikarashi Y, Kase YThe blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansanCell Mol Neurobiol.(2011 Jul)
24.^Wang W, Ma CM, Hattori MMetabolism and pharmacokinetics of rhynchophylline in ratsBiol Pharm Bull.(2010)
25.^Wang W, Ma CM, Hattori MMetabolism of isorhynchophylline in rats detected by LC-MSJ Pharm Pharm Sci.(2010)
26.^Nakazawa T, Banba K, Hata K, Nihei Y, Hoshikawa A, Ohsawa KMetabolites of hirsuteine and hirsutine, the major indole alkaloids of Uncaria rhynchophylla, in ratsBiol Pharm Bull.(2006 Aug)
27.^Gan R, Dong G, Yu J, Wang X, Fu S, Yang SProtective effects of isorhynchophylline on cardiac arrhythmias in rats and guinea pigsPlanta Med.(2011 Sep)
29.^Yuzurihara M, Ikarashi Y, Goto K, Sakakibara I, Hayakawa T, Sasaki HGeissoschizine methyl ether, an indole alkaloid extracted from Uncariae Ramulus et Uncus, is a potent vasorelaxant of isolated rat aortaEur J Pharmacol.(2002 May 31)
31.^Lin RD, Hou WC, Yen KY, Lee MHInhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicinesPhytomedicine.(2003 Nov)
32.^Kawakami Z, Ikarashi Y, Kase YIsoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansanCell Mol Neurobiol.(2011 Nov)
33.^Sun X, Chan LN, Gong X, Sucher NJN-methyl-D-aspartate receptor antagonist activity in traditional Chinese stroke medicinesNeurosignals.(2003 Jan-Feb)
34.^Lee J, Son D, Lee P, Kim DK, Shin MC, Jang MH, Kim CJ, Kim YS, Kim SY, Kim HProtective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampusJ Pharmacol Sci.(2003 May)
36.^Schramm J, Clusmann HThe surgery of epilepsyNeurosurgery.(2008 Feb)
41.^Xian YF, Lin ZX, Zhao M, Mao QQ, Ip SP, Che CTUncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in micePlanta Med.(2011 Dec)
42.^Pengsuparp T, Indra B, Nakagawasai O, Tadano T, Mimaki Y, Sashida Y, Ohizumi Y, Kisara KPharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous systemEur J Pharmacol.(2001 Aug 17)
44.^Ueki T, Nishi A, Imamura S, Kanno H, Mizoguchi K, Sekiguchi K, Ikarashi Y, Kase YEffects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin(7) receptorCell Mol Neurobiol.(2013 Jan)
45.^Takahashi A, Quadros IM, de Almeida RM, Miczek KABrain serotonin receptors and transporters: initiation vs. termination of escalated aggressionPsychopharmacology (Berl).(2011 Feb)
48.^Kanno H, Sekiguchi K, Yamaguchi T, Terawaki K, Yuzurihara M, Kase Y, Ikarashi YEffect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected ratsJ Pharm Pharmacol.(2009 Sep)
50.^Nakagawa T, Nagayasu K, Nishitani N, Shirakawa H, Sekiguchi K, Ikarashi Y, Kase Y, Kaneko SYokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptorNeuroscience.(2012 Dec 27)
51.^Kawakami Z, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase YNeuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cellsNeuroscience.(2009 Apr 10)
55.^Yuan D, Ma B, Yang JY, Xie YY, Wang L, Zhang LJ, Kano Y, Wu CFAnti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanismInt Immunopharmacol.(2009 Dec)
56.^Tang NY, Liu CH, Su SY, Jan YM, Hsieh CT, Cheng CY, Shyu WC, Hsieh CLUncaria rhynchophylla (miq) Jack plays a role in neuronal protection in kainic acid-treated ratsAm J Chin Med.(2010)
58.^Griffin WS, Yeralan O, Sheng JG, Boop FA, Mrak RE, Rovnaghi CR, Burnett BA, Feoktistova A, Van Eldik LJOverexpression of the neurotrophic cytokine S100 beta in human temporal lobe epilepsyJ Neurochem.(1995 Jul)
59.^Sakakibara I, Terabayashi S, Kubo M, Higuchi M, Komatsu Y, Okada M, Taki K, Kamei JEffect on locomotion of indole alkaloids from the hooks of uncaria plantsPhytomedicine.(1999 Jul)
61.^Jung JW, Ahn NY, Oh HR, Lee BK, Lee KJ, Kim SY, Cheong JH, Ryu JHAnxiolytic effects of the aqueous extract of Uncaria rhynchophyllaJ Ethnopharmacol.(2006 Nov 24)
62.^Raedt R, Van Dycke A, Van Melkebeke D, De Smedt T, Claeys P, Wyckhuys T, Vonck K, Wadman W, Boon PSeizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the ratActa Neurol Scand.(2009 May)
63.^Seifert G, Carmignoto G, Steinhäuser CAstrocyte dysfunction in epilepsyBrain Res Rev.(2010 May)
64.^Cavazos JE, Cross DJThe role of synaptic reorganization in mesial temporal lobe epilepsyEpilepsy Behav.(2006 May)
65.^Sutula T, Cascino G, Cavazos J, Parada I, Ramirez LMossy fiber synaptic reorganization in the epileptic human temporal lobeAnn Neurol.(1989 Sep)
66.^Hsieh CL, Chen MF, Li TC, Li SC, Tang NY, Hsieh CT, Pon CZ, Lin JGAnticonvulsant effect of Uncaria rhynchophylla (Miq) Jack. in rats with kainic acid-induced epileptic seizureAm J Chin Med.(1999)
68.^Lo WY, Tsai FJ, Liu CH, Tang NY, Su SY, Lin SZ, Chen CC, Shyu WC, Hsieh CLUncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysisAm J Chin Med.(2010)
69.^Suk K, Kim SY, Leem K, Kim YO, Park SY, Hur J, Baek J, Lee KJ, Zheng HZ, Kim HNeuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in ratsLife Sci.(2002 Apr 21)
73.^Matsuda H, Watanabe N, Geba GP, Sperl J, Tsudzuki M, Hiroi J, Matsumoto M, Ushio H, Saito S, Askenase PW, Ra CDevelopment of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga miceInt Immunol.(1997 Mar)
75.^Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe HAntioxidant and free radical-scavenging activity of Choto-san and its related constituentsBiol Pharm Bull.(2004 Jan)
76.^Lee JS, Yang MY, Yeo H, Kim J, Lee HS, Ahn JSUncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophyllaBioorg Med Chem Lett.(1999 May 17)
77.^Arteaga CL, Johnson MD, Todderud G, Coffey RJ, Carpenter G, Page DLElevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomasProc Natl Acad Sci U S A.(1991 Dec 1)
78.^Noh DY, Lee YH, Kim SS, Kim YI, Ryu SH, Suh PG, Park JGElevated content of phospholipase C-gamma 1 in colorectal cancer tissuesCancer.(1994 Jan 1)
79.^Choi DY, Huh JE, Lee JD, Cho EM, Baek YH, Yang HR, Cho YJ, Kim KI, Kim DY, Park DSUncaria rhynchophylla induces angiogenesis in vitro and in vivoBiol Pharm Bull.(2005 Dec)
81.^Xian YF, Lin ZX, Mao QQ, Hu Z, Zhao M, Che CT, Ip SPBioassay-Guided Isolation of Neuroprotective Compounds from Uncaria rhynchophylla against Beta-Amyloid-Induced NeurotoxicityEvid Based Complement Alternat Med.(2012)
82.^Lu JH, Tan JQ, Durairajan SS, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY, Li MIsorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagyAutophagy.(2012 Jan)
83.^Xian YF, Lin ZX, Mao QQ, Ip SP, Su ZR, Lai XPProtective effect of isorhynchophylline against β-amyloid-induced neurotoxicity in PC12 cellsCell Mol Neurobiol.(2012 Apr)
84.^Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JMMolecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's diseaseProg Neurobiol.(2001 Oct)
85.^Metz GA, Tse A, Ballermann M, Smith LK, Fouad KThe unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysisEur J Neurosci.(2005 Aug)
86.^Shim JS, Kim HG, Ju MS, Choi JG, Jeong SY, Oh MSEffects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson's diseaseJ Ethnopharmacol.(2009 Nov 12)