For glycemic and sleep benefits, doses of 3-5 grams with meals and before bed, respectively, have been used successfully in clinical research.
Glycine
How to Take
Recommended dosage, active amounts, other details
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Human Effect Matrix
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The Human Effect Matrix summarizes human studies to tell you what effects Glycine has on your body, how much evidence there is, and how strong these effects are.
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| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Minor
|
Very High See 2 studies |
There are improvements in cognition due to glycine being able to treat schizophrenia and due to glycine being able to improve sleep; two states of impaired cognition.
|
|
|
|
Minor
|
Very High See 2 studies |
The reduction in fatigue may solely be secondary to how Glycine supplementation can improve sleep quality
|
|
|
|
Minor
|
Very High See all 3 studies |
In persons undergoing mild sleep deprivation, 3g of glycine an hour prior to sleep is able to increase sleep quality and improve self-reports of fatigue and well being the next day due to better sleep.
|
|
|
|
Minor
|
- See study |
Is able to decrease symptoms of schizophrenia similar to both D-serine and sarcosine, but this occurs at an impractically high dose (minimum effective dose being around 800mg/kg bodyweight)
|
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Start your 14-day free trialThings to Note
Is a Form Of
Primary Function:
Also Known As
2-Aminoacetic acid
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